Newest Articles
- Regulation of axonal morphogenesis by the mitochondrial protein Efhd1
Ablation of the mitochondrial protein Efhd1 in mice interferes with normal development of sensory axons and results in mitochondrial dysfunction associated with activation of cellular stress pathways.
- MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling
MAPK mutations favor HNSCC survival, revealing the broad clinical utility of MAPK pathway mutations in prognosis and potentially in precision immunotherapy.
- Pancreatic cancer triggers diabetes through TGF-β–mediated selective depletion of islet β-cells
Pancreatic ductal adenocarcinoma formation culminates in hyperactivation of transforming growth factor β signaling, which in turn induces selective depletion of β-cell mass and thereby leading to new-onset diabetes.
- Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism
Inhibition of the Alzheimer associated γ-secretase impairs the regulation of cellular lipid droplet homeostasis.
- IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis
IL-36 signaling in keratinocytes is crucial for Aldara-induced psoriasis-like dermatitis by controlling IL-23/IL-17A/IL-22 production and neutrophil recruitment at the third day of treatment.
- Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD
Caspase-1 activation in GSDMD-deficient cells induces a rapid form of caspase-3–dependent secondary necrosis that is licenced by caspase-1–induced Bid cleavage and the release of mitochondrial SMAC.
- Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice
This study provides novel insight into Crohn’s disease where α-defensin misfolding resulting from excessive ER stress in Paneth cells induces dysbiosis and disease progression.
- Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes
Immunoglobulins shape mitochondrial function by driving ER expansion, this form of metabolic control is independent of the role the immunoglobulins play as part of the antigen receptor on the cell surface.
- Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis
The hereditary spastic paraplegia protein spastin limits the biogenesis of lipid droplets at the endoplasmic reticulum in a microtubule-independent manner, whereas it promotes lipid droplet movement by binding to the microtubules.