Newest Articles
Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitisSTAT5 controls the intestinal epithelial stem cell niche by regulating Wnt/β-catenin signaling, and lack of active pYSTAT5 induces Clostridium difficile infection. STAT5 may be a transcription factor that restricts niche cell differentiation.
ROS amplification drives mouse spermatogonial stem cell self-renewalAlthough reactive oxygen species (ROS) are required for spermatogonial stem cell (SSC) self-renewal, the mechanism has remained unknown. We show that SSC self-renewal signals activate MAPK14/MAPK7 pathway to induce nuclear translocation of BCL6B and activation of NOX1.
Intra-individual methylomics detects the impact of early-life adversityThis study shows that methylation profile changes across time in the same individual distinguish a stressful experience from typical infancy, providing a potential predictive marker of vulnerability to disease.
Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO miceA new humanized mouse expressing human IL-7 and IL-15 facilitates development and maturation of human NK cells and can be useful as a preclinical in vivo model for testing new treatment modalities.
BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBVHow herpesviruses escape from their latent states is enigmatic, but BZLF1, an important transcription factor of EBV, recruits cellular chromatin remodelers to viral DNA to overcome its epigenetic repression and initiate viral transcription.
Sequence and expression levels of circular RNAs in progenitor cell types during mouse corticogenesisThis study identifies circular RNAs (circRNAs) in specific cell types of the developing mammalian cortex. This resource addresses the complexity and potential significance of this elusive class of transcripts.
Epidermal development requires ninein for spindle orientation and cortical microtubule organizationIn the epidermis, ninein affects spindle orientation of progenitor cells, as well as cortical microtubule organization, desmosome assembly, and lamellar body secretion in differentiating cells.
The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical mannerPI3K and p38 act in a hierarchical manner to enhance mTORC1 activity and stress granule formation; although PI3K is the main driver, the impact of p38 gets apparent as PI3K activity declines.
A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesisOur study highlights a dual role for SAMHD1 in regulating hepatitis B virus cccDNA levels and reverse transcriptase–dependent particle genesis.
Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesisPer-cell quantification of mTORC1 signaling activity in neural stem/progenitor cells reveals differential signaling, proliferative, and tumor-forming capability between dorsal and ventral cells within a single niche.
