Newest Articles
ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathwayThe GET pathway is required to target non-imported mitochondrial carrier proteins to the endoplasmic reticulum, which prevents their deposition into Hsp42-dependent protein foci.
Reduced RNA turnover as a driver of cellular senescenceRNAs originating from transcription upstream and downstream of genes accumulate in the cytoplasm of a subset of senescent cells, suggesting an RNA alternative to cytoplasmic DNA in the triggering of senescence.
MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertilityIn situ proteomics of male infertility.
Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1Main mitotic kinases as PLK1 are activated at the S/G2 transition. A change in Cyclin A2 localisation at the S/G2 transition enables activation of PLK1.
Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectoriesUsing integrated genome-wide and phenotypic methods this study investigates four different mutant RUNX1 oncoproteins and reveals how they differentially contribute to aberrant haematopoiesis.
The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cellsUsing ChIP-seq and functional genomic analyses, the study shows that the Paf1 complex occupies transcriptional enhancers and positively regulates their activity.
Tissue-selective alternate promoters guide NLRP6 expressionThe NLRP6 innate immune sensor is regulated by tissue-selective alternate promoters that facilitate translational gene silencing outside of the intestinal epithelium in both humans and mice.
Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formationN-terminal Aub arginines are dispensable for primary piRNA biogenesis but essential for amplification; their symmetric dimethylation is required for germline inheritance but not for piRNA amplification.
Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse modelsThis study used mice heterozygous for Tp53 mutations with different genetic backgrounds to investigate the genetic or stochastic factors that modify the penetrance of tumor formation by Tp53 mutation.
