Newest Articles
Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitorThe binding properties of fusion inhibitor CBS1117 to hemagglutinin by x-ray crystallography, NMR, and mutagenesis give insights into mechanism and guidance for chemical optimization.
Prion infection, transmission, and cytopathology modeled in a low-biohazard human cell lineExpanding the toolbox of prion research to a low-biohazard, scalable human cell model.
EBV renders B cells susceptible to HIV-1 in humanized miceA proportion of EBV+ B cells are infectible by CXCR4-tropic HIV-1 in vitro and in vivo, and these HIV-infected B cells can transmit infection to previously virus-naïve humanized mice.
Differential regulation of hepatic physiology and injury by the TAM receptors Axl and MerThe TAM receptor tyrosine kinases Mer and Axl play critical roles in liver homeostasis and in the response to both acute and chronic liver injury.
Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cellsThe study use small molecule inhibitors and a kinase-dead expressing mouse model to demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells.
RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levelsThe work highlights the link between dysfunction of the RNA exosome, ribosome biogenesis, p53-dependent signalling, and apoptosis. Pontocerebellar hypoplasia caused by mutations of the exosome subunits could be classified as a ribosomopathy.
Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cellsThis comprehensive study identifies multiple sclerosis risk expression quantitative trait loci in purified immune cell types.
Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondriaA novel, machine-learning approach to quantify cristae density and architecture in live-cell super-resolution imaging characterizes the ultrastructural parameters of individual mitochondria over time.
Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progressionThis study reports a mechanism of mitochondrial ATP generation whereby EMT-inducer Snail controls ACC2 abundance and subsequent fatty acid oxidation to support cancer survival under starvation conditions.
Unbiased yeast screens identify cellular pathways affected in Niemann–Pick disease type CThree independent yeast genetic screens were performed identifying proteins and pathways contributing to the pathogenesis of NPC disease and suggesting new therapeutic avenues.
