Newest Articles
XIAP controls RIPK2 signaling by preventing its deposition in speck-like structuresThis study provides evidence that the NOD1/2-associated kinase RIPK2 localizes to detergent insoluble cytosolic complexes upon activation and suggests novel regulatory mechanisms for RIPK2 signaling.
The early-acting glycosome biogenic protein Pex3 is essential for trypanosome viabilityThis study reports the identification of trypanosome Pex3, the master regulator of glycosome biogenesis. Trypanosome Pex3 is essential for glycosome assembly and trypanosome viability and is distinct from human Pex3.
Stromal fibroblasts induce metastatic tumor cell clusters via epithelial–mesenchymal plasticityThis study highlights the cellular and molecular mechanisms by which stromal fibroblasts enable human breast cancer cells to form tumor cell clusters and acquire highly invasive and metastatic traits.
The miRNA bantam regulates growth and tumorigenesis by repressing the cell cycle regulator tribblesThis work identifies the cell cycle regulator tribbles as a target of the miRNA bantam involved in the growth regulatory and oncogenic functions of bantam in Drosophila epithelia.
TAF-ChIP: an ultra-low input approach for genome-wide chromatin immunoprecipitation assayThe authors present a novel method for obtaining chromatin profiles from low cell numbers without prior nuclei isolation. The method is successfully implemented in generating epigenetic profile from 100 cells with high signal-to-noise ratio.
PRDM9 forms a trimer by interactions within the zinc finger arrayPRDM9 forms a trimer as a soluble protein and in complex with DNA mediated by the ZnF domain. Five ZnFs are already sufficient for multimerization and only one DNA molecule is complexed in the trimer.
Membrane curvature sensing of the lipid-anchored K-Ras small GTPaseProteolipid nanoassemblies of K-Ras and lipids in the plasma membrane sense changing membrane curvature architecture and convert mechanical perturbations to mitogenic signaling.
Human DNA polymerase delta requires an iron–sulfur cluster for high-fidelity DNA synthesisThe iron–sulfur cluster in human DNA polymerase delta has an impact on DNA polymerase and exonuclease activities and can hence influence the fidelity of DNA synthesis.
De novo prediction of cell-type complexity in single-cell RNA-seq and tumor microenvironmentsThis study describes a computational method for determining statistical support to varying levels of heterogeneity provided by single-cell RNA-sequencing data with applications to tumor samples.
