Newest Articles
Somatic recombination underlies frequent revertant mosaicism in loricrin keratodermaWe demonstrate that revertant mosaicism frequently occurs in loricrin keratoderma and that somatic recombination is the major mechanism underlying this therapeutically important phenomenon.
Redundant and nonredundant organismal functions of EPS15 and EPS15L1This study unveils a redundant function for the endocytic proteins Eps15 and Eps15L1 in mouse embryo development and erythropoiesis, and a unique nonredundant role for Eps15L1 in the nervous system.
Mitochondrial stress response triggered by defects in protein synthesis quality controlQuality control defects of mitochondrial nascent chain synthesis trigger a sequential stress response characterized by OMA1 activation and ribosome decay, determining mitochondrial form and function.
Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and functionCostimulation of T cells through both TCR and STING induces growth inhibition by partially blocking the mTORC1 signals, and leads to IFN-I production through sustained activation of IRF3 and mTORC1 activation.
Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogasterDepletion of miRNA-210 disrupts photoreceptor integrity and visual function in Drosophila melanogaster.
Viperin controls chikungunya virus–specific pathogenic T cell IFNγ Th1 stimulation in miceThis study shows that Viperin controls the microenvironment pro-inflammatory response and CD4 T cell–mediated pathogenesis during anti-chikungunya virus immune response in mice.
Folding–function relationship of the most common cystic fibrosis–causing CFTR conductance mutantsThe tight correlation between folding and function in cystic fibrosis patients with CFTR mutations of the altered-conductance CFTR class provides an attractive paradigm for characterizing mode of action of novel therapeutics.
d-amino acid oxidase promotes cellular senescence via the production of reactive oxygen speciesThis study reveals a novel role of d-amino acid oxidase in promoting cellular senescence induced by genotoxic stresses via enzymatic generation of reactive oxygen species.
Rab1b and ARF5 are novel RNA-binding proteins involved in FMDV IRES–driven RNA localizationIntegration of proteomic data with functional and imaging analysis revealed that Rab1b and ARF5, two ER-Golgi members, are RNA-binding proteins that colocalize with picornavirus IRES-RNA reporters in human cells.
KIF18A's neck linker permits navigation of microtubule-bound obstacles within the mitotic spindleThe length of KIF18A's neck linker permits navigation of obstacles along K-fibers within the mitotic spindle and is required for the timely alignment and segregation of mitotic chromosomes.
