Newest Articles
Molecular characterization of CHAD domains as inorganic polyphosphate-binding modulesA domain of unknown function termed CHAD, present in all kingdoms of life, is characterized as a specific inorganic polyphosphate-binding domain.
Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s diseaseThis study describes a gauge for brain aging predictive of cognitive decline and Alzheimer's disease synergistic with the APOE ε4 allele.
The hypoxia-response pathway modulates RAS/MAPK–mediated cell fate decisions in Caenorhabditis elegansAtmospheric oxygen levels modulate the RAS/MAPK signaling pathway in the nematode Caenorhabditis elegans through a cross-talk between the DELTA/NOTCH and hypoxia signaling pathways. These mechanisms may permit the animals to adapt their development to changes in the environment.
Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degenerationSustained loss of PGC-1α in RPE cells triggers mitochondrial/autophagic dysfunction and oxidative damage resulting in epithelial dedifferentiation and mesenchymal transition. RPE dysfunction caused by deletion of the PGC-1 coactivators in vivo causes retinal degeneration.
An N-terminal–truncated isoform of FAM134B (FAM134B-2) regulates starvation-induced hepatic selective ER-phagyThis study has identified a novel truncated isoform of FAM134B (FAM134B-2) that regulates starvation-induced selective ER-phagy of secretory proteins such as ApoCIII through the activation of C/EBPβ.
MicroRNA-155 is essential for the optimal proliferation and survival of plasmablast B cellsTracking antigen-specific B cells in vivo since the onset of antigen stimulation shows that miR-155 regulates the early expansion of B-blasts and later on the optimal proliferation and survival of plasmablasts in a B-cell–intrinsic manner.
Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3Chitinase 1 (CHIT1) plays a role in the pathogenesis of pulmonary fibrosis by modulating canonical and noncanonical TGF-β signaling via interaction with TGFBRAP1 and FOXO3. These findings highlight the CHIT1/SMAD7 axis as a potential biomarker and therapeutic target of pulmonary fibrosis.
Cellular response upon proliferation in the presence of an active mitotic checkpointCells that replicate with an active mitotic checkpoint remain capable to mount multiple times an efficient arrest, are bigger than unperturbed cells, rely more heavily on Cdh1, and have an altered protein expression profile.
Development of a new monoclonal antibody specific to mouse Vγ6 chainUsing a novel mAb specific to Vγ6 TCR, we find Vγ6+ γδT cells are located in association with medullary thymic epithelial cells and play crucial roles in protection against Klebsiella pneumoniae infection but are pathogenic in psoriasis-like dermatitis in agreement with earlier studies.
Noncoding AUG circRNAs constitute an abundant and conserved subclass of circlesAUG circRNAs are highly abundant and conserved with an Alu-independent mode of biogenesis. Although AUG circRNAs contain the N-terminal ORFs, no evidence supports translation of these circRNAs.
