Newest Articles
SCFCdc4 ubiquitin ligase regulates synaptonemal complex formation during meiosisDuring meiosis, homologous chromosomes pair to form the synaptonemal complex (SC). This study showed that SCFCdc4 ubiquitin ligase is required for and works with Pch2 AAA+ ATPase for SC assembly.
Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologiesWe found that acute insult to the central nervous system induces the formation of lymphocyte aggregates reminiscent of tertiary lymphoid structures within the spinal cord meninges. Unlike draining CNS-cervical lymph nodes, meningeal lymphocytes are locally activated during neuro-inflammtion and neurodegeneration.
Loss of Jag1 cooperates with oncogenic Kras to induce pancreatic cystic neoplasmsJag1 functions as a tumor suppressor in delaying pancreatic cancer precursor, while at the same time, promotes a phenotypic switch from benign cystic lesions to invasive carcinoma of the pancreas.
Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcomeSingle-cell sequencing of γδ-T cells from human blood and tumours revealed novel markers of subtypes with distinct effector functions and a subtype that is associated with favourable clinical outcome.
Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cellsAutocrine Wnt10b signaling ensures proper mitotic microtubule polymerization and faithful chromosome segregation.
Scratch-induced partial skin wounds re-epithelialize by sheets of independently migrating keratinocytesIntravital microscopy of scratch wounds in the murine skin reveals that individual basal keratinocytes migrate in a swarming fashion towards the wound to bypass intact hair follicles, thereby facilitating fast repair.
Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J miceUsing a number of cell biological and statistical methods we identify and characterize EIF5, TCF25 and BIN1 as markers for individual brown adipocyte subtypes in C57BL/6J mice.
Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic networkUsing genomic and structural information from SARS-CoV-2, we created a biomass function capturing its amino and nucleic acid requirements and incorporated this into a metabolic model of the human lung cell to predict metabolic perturbations that inhibit virus reproduction.
BRD2 regulation of sigma-2 receptor upon cholesterol deprivationUpon cholesterol deprivation, epigenetic bookmark reader BRD2 and master transcription factor SREBP2 form a complex at bookmarked chromatin (H3K27ac), thereby activating the transcription of the sigma-2 receptor—a recently unveiled player in cholesterol homeostasis.
G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammationGranulocyte colony-stimulating factor suppresses erythropoiesis of bone marrow and promotes splenic erythropoiesis during lipopolysaccharide-induced systemic inflammation in mice.
