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Newest Articles

  • SCF<sup>Cdc4</sup> ubiquitin ligase regulates synaptonemal complex formation during meiosis
    Open Access
    SCFCdc4 ubiquitin ligase regulates synaptonemal complex formation during meiosis

    Zhihui Zhu, Mohammad Bani Ismail, Miki Shinohara, Akira Shinohara

    Zhihui Zhu ... Akira Shinohara

    Published 8 December 2020

    During meiosis, homologous chromosomes pair to form the synaptonemal complex (SC). This study showed that SCFCdc4 ubiquitin ligase is required for and works with Pch2 AAA+ ATPase for SC assembly.

  • Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies
    Open Access
    Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies

    Merav Cohen, Amir Giladi, Catarina Raposo, Mor Zada, Baoguo Li, Julia Ruckh, Aleksandra Deczkowska, Boaz Mohar, Ravid Shechter, Rachel G Lichtenstein, Ido Amit, Michal Schwartz

    Merav Cohen ... Michal Schwartz

    Published 4 December 2020

    We found that acute insult to the central nervous system induces the formation of lymphocyte aggregates reminiscent of tertiary lymphoid structures within the spinal cord meninges. Unlike draining CNS-cervical lymph nodes, meningeal lymphocytes are locally activated during neuro-inflammtion and neurodegeneration.

  • Loss of <em>Jag1</em> cooperates with oncogenic <em>Kras</em> to induce pancreatic cystic neoplasms
    Open Access
    Loss of Jag1 cooperates with oncogenic Kras to induce pancreatic cystic neoplasms

    Wen-Cheng Chung, Lavanya Challagundla, Yunyun Zhou, Min Li, Azeddine Atfi, Keli Xu

    Wen-Cheng Chung ... Keli Xu

    Published 2 December 2020

    Jag1 functions as a tumor suppressor in delaying pancreatic cancer precursor, while at the same time, promotes a phenotypic switch from benign cystic lesions to invasive carcinoma of the pancreas.

  • Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome
    Open Access
    Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome

    Katerina Boufea, Víctor González-Huici, Marcus Lindberg, Stefan Symeonides, Olga Oikonomidou, Nizar N Batada

    Katerina Boufea ... Nizar N Batada

    Published 2 December 2020

    Single-cell sequencing of γδ-T cells from human blood and tumours revealed novel markers of subtypes with distinct effector functions and a subtype that is associated with favourable clinical outcome.

  • Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells
    Open Access
    Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells

    Yu-Chih Lin, Alexander Haas, Anja Bufe, Sabnam Parbin, Magdalena Hennecke, Oksana Voloshanenko, Julia Gross, Michael Boutros, Sergio P Acebron, Holger Bastians

    Yu-Chih Lin ... Holger Bastians

    Published 30 November 2020

    Autocrine Wnt10b signaling ensures proper mitotic microtubule polymerization and faithful chromosome segregation.

  • Scratch-induced partial skin wounds re-epithelialize by sheets of independently migrating keratinocytes
    Open Access
    Scratch-induced partial skin wounds re-epithelialize by sheets of independently migrating keratinocytes

    Laura Bornes, Reinhard Windoffer, Rudolf E Leube, Jessica Morgner, Jacco van Rheenen

    Laura Bornes ... Jacco van Rheenen

    Published 30 November 2020

    Intravital microscopy of scratch wounds in the murine skin reveals that individual basal keratinocytes migrate in a swarming fashion towards the wound to bypass intact hair follicles, thereby facilitating fast repair.

  • Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice
    Open Access
    Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice

    Ruth Karlina, Dominik Lutter, Viktorian Miok, David Fischer, Irem Altun, Theresa Schöttl, Kenji Schorpp, Andreas Israel, Cheryl Cero, James W Johnson, Ingrid Kapser-Fischer, Anika Böttcher, Susanne Keipert, Annette Feuchtinger, Elisabeth Graf, Tim Strom, Axel Walch, Heiko Lickert, Thomas Walzthoeni, Matthias Heinig, Fabian J Theis, Cristina García-Cáceres, Aaron M Cypess, Siegfried Ussar

    Ruth Karlina ... Siegfried Ussar

    Published 30 November 2020

    Using a number of cell biological and statistical methods we identify and characterize EIF5, TCF25 and BIN1 as markers for individual brown adipocyte subtypes in C57BL/6J mice.

  • Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network
    Open Access
    Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network

    Hadrien Delattre, Kalesh Sasidharan, Orkun S Soyer

    Hadrien Delattre ... Orkun S Soyer

    Published 24 November 2020

    Using genomic and structural information from SARS-CoV-2, we created a biomass function capturing its amino and nucleic acid requirements and incorporated this into a metabolic model of the human lung cell to predict metabolic perturbations that inhibit virus reproduction.

  • BRD2 regulation of sigma-2 receptor upon cholesterol deprivation
    Open Access
    BRD2 regulation of sigma-2 receptor upon cholesterol deprivation

    Hongtao Shen, Jing Li, Xiujie Xie, Huan Yang, Mengxue Zhang, Bowen Wang, K Craig Kent, Jorge Plutzky, Lian-Wang Guo

    Hongtao Shen ... Lian-Wang Guo

    Published 24 November 2020

    Upon cholesterol deprivation, epigenetic bookmark reader BRD2 and master transcription factor SREBP2 form a complex at bookmarked chromatin (H3K27ac), thereby activating the transcription of the sigma-2 receptor—a recently unveiled player in cholesterol homeostasis.

  • G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation
    Open Access
    G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation

    Weiqiang Jing, Xing Guo, Fei Qin, Yue Li, Ganyu Wang, Yuxuan Bi, Xing Jin, Lihui Han, Xiaoyuan Dong, Yunxue Zhao

    Weiqiang Jing ... Yunxue Zhao

    Published 24 November 2020

    Granulocyte colony-stimulating factor suppresses erythropoiesis of bone marrow and promotes splenic erythropoiesis during lipopolysaccharide-induced systemic inflammation in mice.

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Current Issue

Volume 4, No. 2
February 2021
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  • TMPRSS2 and furin activate SARS-CoV-2
  • SOCS1 regulates immunotherapy in NSCLC
  • Mutant RUNX1 perturbs differentiation
  • A FIJI macro for quantifying fibrillar patterns
  • Cytoplasmic cyclin A2 initiates PLK1 activation
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