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Newest Articles

  • Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression
    Open Access
    Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression

    André F Rendeiro, Joseph Casano, Charles Kyriakos Vorkas, Harjot Singh, Ayana Morales, Robert A DeSimone, Grant B Ellsworth, Rosemary Soave, Shashi N Kapadia, Kohta Saito, Christopher D Brown, JingMei Hsu, Christopher Kyriakides, Steven Chiu, Luca Vincenzo Cappelli, Maria Teresa Cacciapuoti, Wayne Tam, Lorenzo Galluzzi, Paul D Simonson, Olivier Elemento, Mirella Salvatore, Giorgio Inghirami

    André F Rendeiro ... Giorgio Inghirami

    Published 24 December 2020

    Deep immune profiling of COVID-19 patients with different disease severity reveals populations associated with severe disease and can be used to predict disease severity early on.

  • IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling
    Open Access
    IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling

    Karen Dunbar, Thomas J Macartney, Gopal P Sapkota

    Karen Dunbar ... Gopal P Sapkota

    Published 23 December 2020

    IMiDs induce the degradation of the FAM83F–CK1α complex but no other FAM83–CK1α complexes, resulting in attenuation of Wnt signalling.

  • The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies
    Open Access
    The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies

    Gaylor Boulay, Luisa Cironi, Sara P Garcia, Shruthi Rengarajan, Yu-Hang Xing, Lukuo Lee, Mary E Awad, Beverly Naigles, Sowmya Iyer, Liliane C Broye, Tugba Keskin, Alexandra Cauderay, Carlo Fusco, Igor Letovanec, Ivan Chebib, Petur Gunnalugur Nielsen, Stéphane Tercier, Stéphane Cherix, Tu Nguyen-Ngoc, Gregory Cote, Edwin Choy, Paolo Provero, Mario L Suvà, Miguel N Rivera, Ivan Stamenkovic, Nicolò Riggi

    Gaylor Boulay ... Nicolò Riggi

    Published 23 December 2020

    We have addressed the mechanisms by which the fusion protein SS18-SSX modifies the epigenome toward the development of synovial sarcoma and the establishment of its potentially targetable vulnerabilities.

  • Polycomb mutant partially suppresses DNA hypomethylation–associated phenotypes in Arabidopsis
    Open Access
    Polycomb mutant partially suppresses DNA hypomethylation–associated phenotypes in Arabidopsis

    Martin Rougée, Leandro Quadrana, Jérôme Zervudacki, Valentin Hure, Vincent Colot, Lionel Navarro, Angélique Deleris

    Martin Rougée ... Angélique Deleris

    Published 21 December 2020

    A mutation in Arabidopsis polycomb repressive complex 2 partially suppresses the transposon activity observed in a DNA methylation mutant, challenging expectations.

  • Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4
    Open Access
    Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4

    Andreia Mendes, Julien P Gigan, Christian Rodriguez Rodrigues, Sébastien A Choteau, Doriane Sanseau, Daniela Barros, Catarina Almeida, Voahirana Camosseto, Lionel Chasson, Adrienne W Paton, James C Paton, Rafael J Argüello, Ana-Maria Lennon-Duménil, Evelina Gatti, Philippe Pierre

    Andreia Mendes ... Philippe Pierre

    Published 21 December 2020

    Differentiated dendritic cells display an unusual activation of the integrated stress response, which is necessary for normal type-I Interferon production and cell migration.

  • FIREWORKS: a bottom-up approach to integrative coessentiality network analysis
    Open Access
    FIREWORKS: a bottom-up approach to integrative coessentiality network analysis

    David R Amici, Jasen M Jackson, Mihai I Truica, Roger S Smith, Sarki A Abdulkadir, Marc L Mendillo

    David R Amici ... Marc L Mendillo

    Published 16 December 2020

    A tool to create bias-adjusted coessentiality networks reveals functional relationships between genes, context-specific rewiring of genetic networks, determinants of essentiality, and therapeutic targets for challenging proteins.

  • Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in <em>Drosophila</em>
    Open Access
    Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila

    Anne-Claire Jacomin, Raksha Gohel, Zunoon Hussain, Agnes Varga, Tamas Maruzs, Mark Eddison, Margaux Sica, Ashish Jain, Kevin G Moffat, Terje Johansen, Andreas Jenny, Gabor Juhasz, Ioannis P Nezis

    Anne-Claire Jacomin ... Ioannis P Nezis

    Published 14 December 2020

    Drosophila EPS8-family protein Arouser is constitutively degraded by endosomal microautophagy; its stabilisation upon starvation is essential to the animal adaptation and survival.

  • Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK–driven lymphomagenesis
    Open Access
    Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK–driven lymphomagenesis

    Elisa Redl, Raheleh Sheibani-Tezerji, Crhistian de Jesus Cardona, Patricia Hamminger, Gerald Timelthaler, Melanie Rosalia Hassler, Maša Zrimšek, Sabine Lagger, Thomas Dillinger, Lorena Hofbauer, Kristina Draganić, Andreas Tiefenbacher, Michael Kothmayer, Charles H Dietz, Bernard H Ramsahoye, Lukas Kenner, Christoph Bock, Christian Seiser, Wilfried Ellmeier, Gabriele Schweikert, Gerda Egger

    Elisa Redl ... Gerda Egger

    Published 11 December 2020

    NPM-ALK–driven lymphoma in mice is dependent on MYC signaling and epigenomic reprogramming via DNA methyltransferases, resulting in heterogenous DNA methylation signatures reminiscent of human lymphoma.

  • Sustained <em>Helicobacter pylori</em> infection accelerates gastric dysplasia in a mouse model
    Open Access
    Sustained Helicobacter pylori infection accelerates gastric dysplasia in a mouse model

    Valerie P O’Brien, Amanda L Koehne, Julien Dubrulle, Armando E Rodriguez, Christina K Leverich, V Paul Kong, Jean S Campbell, Robert H Pierce, James R Goldenring, Eunyoung Choi, Nina R Salama

    Valerie P O’Brien ... Nina R Salama

    Published 11 December 2020

    Hp infection was found to alter metaplasia and accelerate dysplasia in mice. Thus, Hp can promote gastric preneoplastic progression, in addition to its known role in initiating chronic inflammation.

  • ESI mutagenesis: a one-step method for introducing mutations into bacterial artificial chromosomes
    Open Access
    ESI mutagenesis: a one-step method for introducing mutations into bacterial artificial chromosomes

    Arnaud Rondelet, Andrei Pozniakovsky, Devika Namboodiri, Richard Cardoso da Silva, Divya Singh, Marit Leuschner, Ina Poser, Andrea Ssykor, Julian Berlitz, Nadine Schmidt, Lea Röhder, Gerben Vader, Anthony A Hyman, Alexander W Bird

    Arnaud Rondelet ... Alexander W Bird

    Published 8 December 2020

    A simple and efficient recombineering-based method for introducing point mutations into bacterial artificial chromosomes using an artificial intron cassette.

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Issue Cover

Current Issue

Volume 4, No. 2
February 2021
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  • TMPRSS2 and furin activate SARS-CoV-2
  • SOCS1 regulates immunotherapy in NSCLC
  • Mutant RUNX1 perturbs differentiation
  • A FIJI macro for quantifying fibrillar patterns
  • Cytoplasmic cyclin A2 initiates PLK1 activation
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