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Newest Articles

  • Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories
    Open Access
    Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories

    Sophie G Kellaway, Peter Keane, Benjamin Edginton-White, Kakkad Regha, Ella Kennett, Constanze Bonifer

    Sophie G Kellaway ... Constanze Bonifer

    Published 4 January 2021

    Using integrated genome-wide and phenotypic methods this study investigates four different mutant RUNX1 oncoproteins and reveals how they differentially contribute to aberrant haematopoiesis.

  • Tissue-selective alternate promoters guide NLRP6 expression
    Open Access
    Tissue-selective alternate promoters guide NLRP6 expression

    Nathan A Bracey, Jaye M Platnich, Arthur Lau, Hyunjae Chung, M Eric Hyndman, Justin A MacDonald, Justin Chun, Paul L Beck, Stephen E Girardin, Paul MK Gordon, Daniel A Muruve

    Nathan A Bracey ... Daniel A Muruve

    Published 29 December 2020

    The NLRP6 innate immune sensor is regulated by tissue-selective alternate promoters that facilitate translational gene silencing outside of the intestinal epithelium in both humans and mice.

  • The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells
    Open Access
    The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells

    Li Ding, Maciej Paszkowski-Rogacz, Jovan Mircetic, Debojyoti Chakraborty, Frank Buchholz

    Li Ding ... Frank Buchholz

    Published 29 December 2020

    Using ChIP-seq and functional genomic analyses, the study shows that the Paf1 complex occupies transcriptional enhancers and positively regulates their activity.

  • Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formation
    Open Access
    Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formation

    Nicholas Vrettos, Manolis Maragkakis, Panagiotis Alexiou, Paraskevi Sgourdou, Fadia Ibrahim, Daniel Palmieri, Yohei Kirino, Zissimos Mourelatos

    Nicholas Vrettos ... Zissimos Mourelatos

    Published 29 December 2020

    N-terminal Aub arginines are dispensable for primary piRNA biogenesis but essential for amplification; their symmetric dimethylation is required for germline inheritance but not for piRNA amplification.

  • Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse models
    Open Access
    Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse models

    Chang S Chan, Yvonne Sun, Hua Ke, Yuhan Zhao, Merzu Belete, Cen Zhang, Zhaohui Feng, Arnold J Levine, Wenwei Hu

    Chang S Chan ... Wenwei Hu

    Published 29 December 2020

    This study used mice heterozygous for Tp53 mutations with different genetic backgrounds to investigate the genetic or stochastic factors that modify the penetrance of tumor formation by Tp53 mutation.

  • The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions
    Open Access
    The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions

    Baskar Chakrapani, Mohd Imran K Khan, Rajashekar Varma Kadumuri, Somlee Gupta, Mamta Verma, Sharad Awasthi, Gayathri Govindaraju, Arun Mahesh, Arumugam Rajavelu, Sreenivas Chavali, Arunkumar Dhayalan

    Baskar Chakrapani ... Arunkumar Dhayalan

    Published 29 December 2020

    The uncharacterized protein FAM47E interacts with and stabilizes the protein arginine methyltransferase PRMT5, regulating its epigenetic functions thereby modulating target gene expression.

  • The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells
    Open Access
    The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells

    Maria Inês Alvelos, Mirko Brüggemann, FX Reymond Sutandy, Jonàs Juan-Mateu, Maikel Luis Colli, Anke Busch, Miguel Lopes, Ângela Castela, Annemieke Aartsma-Rus, Julian König, Kathi Zarnack, Décio L Eizirik

    Maria Inês Alvelos ... Décio L Eizirik

    Published 29 December 2020

    The RNA-binding protein SRSF6 recognizes a purine-rich consensus motif consisting of GAA triplets, and its downregulation in human pancreatic β-cells affects alternative splicing in a position-dependent manner.

  • Paneth cell–derived growth factors support tumorigenesis in the small intestine
    Open Access
    Paneth cell–derived growth factors support tumorigenesis in the small intestine

    Qing Chen, Kohei Suzuki, Luis Sifuentes-Dominguez, Naoteru Miyata, Jie Song, Adam Lopez, Petro Starokadomskyy, Purva Gopal, Igor Dozmorov, Shuai Tan, Bujun Ge, Ezra Burstein

    Qing Chen ... Ezra Burstein

    Published 28 December 2020

    Paneth cells, known for their production of antimicrobial peptides and growth factors in the gut epithelium, are found to play a key role in intestinal tumor formation through secretion of Wnt3.

  • HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails
    Open Access
    HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails

    Pablo Barbeito, Yuki Tachibana, Raquel Martin-Morales, Paula Moreno, Kirk Mykytyn, Tetsuo Kobayashi, Francesc R Garcia-Gonzalo

    Pablo Barbeito ... Francesc R Garcia-Gonzalo

    Published 28 December 2020

    Ciliary accumulation of G protein–coupled receptors HTR6 and SSTR3 depends on redundant ciliary targeting sequences acting via ciliary trafficking adapters TULP3 and RABL2.

  • FAM83F regulates canonical Wnt signalling through an interaction with CK1α
    Open Access
    FAM83F regulates canonical Wnt signalling through an interaction with CK1α

    Karen Dunbar, Rebecca A Jones, Kevin Dingwell, Thomas J Macartney, James C Smith, Gopal P Sapkota

    Karen Dunbar ... Gopal P Sapkota

    Published 24 December 2020

    FAM83F directs CK1α to the plasma membrane, and through its association with CK1α, FAM83F mediates canonical Wnt signalling.

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Issue Cover

Current Issue

Volume 4, No. 2
February 2021
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  • TMPRSS2 and furin activate SARS-CoV-2
  • SOCS1 regulates immunotherapy in NSCLC
  • Mutant RUNX1 perturbs differentiation
  • A FIJI macro for quantifying fibrillar patterns
  • Cytoplasmic cyclin A2 initiates PLK1 activation
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