Newest Articles
Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectoriesUsing integrated genome-wide and phenotypic methods this study investigates four different mutant RUNX1 oncoproteins and reveals how they differentially contribute to aberrant haematopoiesis.
Tissue-selective alternate promoters guide NLRP6 expressionThe NLRP6 innate immune sensor is regulated by tissue-selective alternate promoters that facilitate translational gene silencing outside of the intestinal epithelium in both humans and mice.
The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cellsUsing ChIP-seq and functional genomic analyses, the study shows that the Paf1 complex occupies transcriptional enhancers and positively regulates their activity.
Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formationN-terminal Aub arginines are dispensable for primary piRNA biogenesis but essential for amplification; their symmetric dimethylation is required for germline inheritance but not for piRNA amplification.
Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse modelsThis study used mice heterozygous for Tp53 mutations with different genetic backgrounds to investigate the genetic or stochastic factors that modify the penetrance of tumor formation by Tp53 mutation.
The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functionsThe uncharacterized protein FAM47E interacts with and stabilizes the protein arginine methyltransferase PRMT5, regulating its epigenetic functions thereby modulating target gene expression.
The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cellsThe RNA-binding protein SRSF6 recognizes a purine-rich consensus motif consisting of GAA triplets, and its downregulation in human pancreatic β-cells affects alternative splicing in a position-dependent manner.
Paneth cell–derived growth factors support tumorigenesis in the small intestinePaneth cells, known for their production of antimicrobial peptides and growth factors in the gut epithelium, are found to play a key role in intestinal tumor formation through secretion of Wnt3.
HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tailsCiliary accumulation of G protein–coupled receptors HTR6 and SSTR3 depends on redundant ciliary targeting sequences acting via ciliary trafficking adapters TULP3 and RABL2.
FAM83F regulates canonical Wnt signalling through an interaction with CK1αFAM83F directs CK1α to the plasma membrane, and through its association with CK1α, FAM83F mediates canonical Wnt signalling.
