Newest Articles
DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesisIn intestinal epithelial cells (IECs), DDX5 promotes the expression of immune response genes and oncogenes posttranscriptionally and is a novel therapeutic target for treating colitis and intestinal cancers.
Thymosin α1 protects from CTLA-4 intestinal immunopathologyThis study demonstrates that Tα1 protects mice from anti–CTLA-4–induced colitis and sustains its antitumor activity, thus suggesting that Tα1 may be used in combination protocols.
MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexesApolipoproteins of MICOS, MIC26 and MIC27, cooperatively manage cristae structure, cardiolipin levels, and the global stability and integrity of respiratory chain supercomplexes and F1Fo–ATP synthase.
The bacterial quorum sensing signal DSF hijacks Arabidopsis thaliana sterol biosynthesis to suppress plant innate immunityThis study highlights that DSF, the quorum sensing signal produced by bacterial phytopathogens, is able to directly modulate plant plasma membrane dynamics by interfering with host lipid profile and thereby, suppress plant immunity responses.
Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCUUsing clues from evolution, chimeric proteins, and biochemical methods, this work identifies a new domain in mitochondrial calcium uniporter that determines its dependence on its binding partner EMRE.
Exploiting somatic piRNAs in Bemisia tabaci enables novel gene silencing through RNA feedingRNAi usually relies on Dicer-produced siRNAs to induce gene silencing. In many arthropods, another type of RNAi is present in the soma—the piRNA pathway. This work finds exploiting this biology is a viable alternative for gene knockdown.
Peptide-based quorum sensing systems in Paenibacillus polymyxaDiscovery of conserved communication systems in the agriculturally important Paenibacillus bacteria. These systems are widespread, and some species encode more than 25 different peptide-receptor pairs.
Sam68 splicing regulation contributes to motor unit establishment in the postnatal skeletal muscleSam68 ensures the establishment of neuromuscular junctions (NMJs) and motor unit integrity by orchestrating a neuronal splicing program.
Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolutionGenome-wide analysis of R-loop alterations in U2OS cells deficient of DDX5, XRN2, and PRMT5 identify >50,650 DRIP-seq peaks spanning ∼4.5% of the genomic sequence. R-loops near TSS generated intergenic antisense transcription.
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortalityAffinity-based proteomics assays identify particular profiles of the circulating histidine-rich glycoprotein to increase with age and elevated levels to indicate a higher risk of all-cause mortality.
