Newest Articles
Notch1 signaling determines the plasticity and function of fibroblasts in diabetic woundsNotch1 signaling determines the plasticity and function of fibroblasts in diabetic wounds and may serve as a potential target for therapeutic intervention in diabetic wound healing.
Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activityPharmacological inhibition of ULK1 with multiple and distinct small molecules does not block autophagosome initiation but does impair autophagic flux.
Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradationThe balance between HIPK2-mediated phosphorylation and neddylation-dependent degradation controls spastin protein levels, revealing novel therapeutic targets for hereditary spastic paraplegia.
Chromosome instability induced by a single defined sister chromatid fusionNewly developed Fusion Visualization (FuVis) system reveals a single Xp sister chromatid fusion induces micronuclei formation, acentric chromosome fragments, and cell cycle instabilities.
Plasmodium DEH is ER-localized and crucial for oocyst mitotic division during malaria transmissionPlasmodium DEH localizes to the ER, with gene deletion resulting in degeneration of developing oocysts and complete ablation of sporogony in the mosquito midgut, blocking transmission.
Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytesUbiquitin signals the sorting of Cx43 into EVs, which is impaired during ischemia, resulting in decreased levels of Cx43 in cardiomyocyte-derived and circulating EVs from myocardial infarcted patients.
Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouseThe vital role of the splicing factor SRRM4 in vestibular and inner hair cells of the ear is inactivation of the gene repressor REST; however, in outer hair cells, SRRM4 is dispensable for REST inactivation, which SRRM3 accomplishes independently.
Brain is an endocrine organ through secretion and nuclear transfer of parathymosinThe hypothalamus and brain neurons orchestrate the secretion and nuclear transfer of PTMS which is neuroprotective against aging-related disorders.
Incipient sympatric speciation in wild barley caused by geological-edaphic divergenceSympatric speciation is still contentious but here based on genome-wide analysis; we show incipient sympatric speciation of an emerging new wild barley species from Hordeum spontaneum, the progenitor of all cultivated barleys at “Evolution Plateau” (EP), Upper Galilee, Israel.
Role of opioid signaling in kidney damage during the development of salt-induced hypertensionStimulation of kappa opioid receptors modulates calcium influx via TRPC6 channels in podocytes, which ultimately compromises the integrity of the glomerular filtration barrier and promotes a marked worsening of blood pressure control and renal damage.
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