Newest Articles
- Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect
Overexpression of Rif1 induces relocation of chromatin to nuclear periphery and mitotic defect, suggesting a role of regulated chromatin–nuclear membrane association in the proper progression of M phase.
- The organizer of chromatin topology RIF1 ensures cellular resilience to DNA replication stress
The conserved protein RIF1 stabilizes replication factories and regulates cohesin recruitment in response to replication stress to limit DNA lesions.
- Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress
This study reports that NLRP3 is down-regulated in cancers and identifies a novel non-immune function for NLRP3 in maintaining genome integrity through the control of ATM activation in response to DSB.
- A practical comparison of the next-generation sequencing platform and assemblers using yeast genome
This research analyzes the general and optimal de novo yeast assembly pipeline using the repetitive yeast genome assembly by benchmarking four different sequencing platforms and seven assembly programs.
- Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathway
Cholesterol metabolism may be involved in the early steps of tumor dissemination. Epigenetic regulation of cholesterol synthesis and uptake is of great importance in this process and may constitute a vulnerability of the cancer cell that could be exploited pharmacologically.
- Epigenetic signals that direct cell type–specific interferon beta response in mouse cells
Preexisting cell type–specific chromatin features represent an additional regulatory layer for interferon beta response and direct binding of STAT transcription factors and gene induction.
- Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencing
The plant mobile domain proteins MAIN and MAIL1 control the expression of the epigenetic factor Microrchidia 1, which has been involved in transposable element silencing in Arabidopsis.
- A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery
The validation and interpretation of a genome-wide CRISRPko FACS screen via protein–protein interaction data yield a broad view of the molecular network-regulating phagocytosis in human cells.
- Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma
This pan-genomic study of crosstalk between HIF and AHR transcription factors reveals both antagonistic and cooperative interactions and highlights their relevance to kidney cancer and its treatment.
- The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance
This study adds insights into FTSJ1 tRNA 2′-O-methylation–associated pathologies in humans and Drosophila by identification of novel FTSJ1 targets and neuron morphology defects.