Newest Articles
- SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress
Oxidative stress causes a rapid translocation of SIRT6 from the nucleus to the cytoplasm leading to nuclear SIRT6 depletion and results in RPE damage that is more severe in the central region in mice.
- BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes implicated in prostate cancer
BAZ2A-mediated repression in prostate cancer is regulated by the RNA-binding TAM domain. The BAZ2A-TAM domain, in association with RNA, promotes the interaction with TOP2A and KDM1A that serves to repress genes critical to prostate cancer progression.
- The cytochrome b carboxyl terminal region is necessary for mitochondrial complex III assembly
Synthesis/assembly of Cytb, encoded in the mitochondrial DNA, are regulated by the Cytb C-terminus. It modifies the interaction Cytb-Cbp3/Cbp6 to control Cytb and respiratory complex III biogenesis.
- MiR-532-3p inhibited the methylation of SOCS2 to suppress the progression of PC by targeting DNMT3A
MiR-532-3p has a low expression in pancreatic cancer, but its overexpression can inhibit the tumor progression via DNMT3A-dependent inhibition of SOCS2 methylation.
- Low-density lipoprotein receptor–related protein 1 (LRP1) as an auxiliary host factor for RNA viruses
Plasma membrane–located low-density lipoprotein receptor–related protein 1 (LRP1 or CD91) is a host factor that supports the early infection stages of a spectrum of RNA viruses.
- The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells
A co-culture model of human primary endothelial cells and organoid-derived epithelial cells shows that endothelial cells are abortively infected by influenza A virus but can drive the pro-inflammatory response.
- Yolk-deprived Caenorhabditis elegans secure brood size at the expense of competitive fitness
Many egg-laying species lower fecundity when yolk is in short supply, but not C. elegans. They still produce abundant offspring, yet of decreased quality.
- Cognitive decline in diabetic mice predisposed to Alzheimer’s disease is greater than in wild type
This work proposes that T2DM is particularly harmful to brain function in individuals with a genetic predisposition to neurodegenerative pathology via, among others, γ-secretase inhibition.
- Sleep–wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice
This study found that age-associated sleep changes are ameliorated by DR in the presence of Prdm13 signaling in the DMH, suggesting Prdm13+ DMH neurons will be of great interest to explore a potential intervention on age-associated sleep changes.
- Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection
A soluble ACE2 protein bioengineered to have extended duration of action and enhanced affinity for SARS-CoV-2 provides markedly improved survival and organ protection when administered intranasally. Reducing brain SARS-CoV-2 titers is an important determinant of therapeutic efficacy.