Newest Articles
- Missense variant interaction scanning reveals a critical role of the FERM domain for tumor suppressor protein NF2 conformation and function
Deep mutational interaction perturbation scanning of NF2 with conformation-dependent interaction partners KDM1A, EMILIN, and PIK3R3 revealed two regions critical for NF2 tumor suppressor function.
- STING is redundant for host defense and pathology of COVID-19-like disease in mice
STING-deficient mice infected with SARS-CoV-2 do not show altered disease development or viral load, nor any major differences in inflammatory responses.
- Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitis
Experiments using humanized mice created by knocking in microRNA (miR)-33b into an intron of Srebf1 show that suppression of miR-33b by nucleic acid drugs is useful for the treatment of NASH.
- Amphid sensory neurons of Caenorhabditis elegans orchestrate its survival from infection with broad classes of pathogens
This study shows that the nervous system of the bacterivorous nematode Caenorhabditis elegans coordinates pathogen-specific and broad immune responses during infection.
- A new metabolic model of Drosophila melanogaster and the integrative analysis of Parkinson’s disease
The reconstruction of a comprehensive and literature-curated Drosophila metabolic model, iDrosophila1, provided a powerful platform for studying metabolism with systems medicine perspective.
- Estimation of crossbridge-state during cardiomyocyte beating using second harmonic generation
This article describes a new method to evaluate the actomyosin activity in living cardiomyocytes during beating based on nonlinear scattering microscopy, which will be useful for elucidating cardiomyopathy mechanisms, efficacy of an intervention, and others.
- Modeling fibrotic alveolar transitional cells with pluripotent stem cell-derived alveolar organoids
In vitro modeling of transitional alveolar epithelial cells in idiopathic pulmonary fibrosis by the use of a fibrosis cocktail and alveolar organoids from induced pluripotent stem cells.
- UHRF1 is essential for proper cytoplasmic architecture and function of mouse oocytes and derived embryos
This study shows that the UHRF1 protein, an epigenetic factor, regulates cytoplasmic proteins in oocytes independently of gene expression and ensures normal preimplantation development.
- Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis
The study highlights the importance of maintaining appropriate H3K4me3 levels to prevent negative impacts on nerve system homeostasis across generations.
- MAP4K3 inhibits Sirtuin-1 to repress the LKB1–AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex
Our results reveal the existence of a novel signaling pathway linking amino acid satiety with MAP4K3-dependent suppression of SIRT1 to inactivate the repressive LKB1–AMPK pathway and thereby potently activate the mTORC1 complex to dictate the metabolic disposition of the cell.