Newest Articles
- N-terminal proteoforms may engage in different protein complexes
Proteins originating from the same gene, yet differing at their N-terminus—so-called N-terminal proteoforms—can take part in different protein–protein interactions.
- PI3P-dependent regulation of cell size and autophagy by phosphatidylinositol 5-phosphate 4-kinase
PIP4K is a lipid kinase implicated in tumour growth, immune function, and metabolic regulation. This study shows that PIP4K regulates PI3P levels and autophagy, thereby controlling cell size in Drosophila salivary glands.
- Hypoxia controls expression of kidney-pathogenic MUC1 variants
Hypoxia or pharmacological treatment with novel HIF stabilizers promotes the expression of MUC1 genetic variants that predispose to the development of chronic kidney disease in renal tubular cells.
- SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing
SLIT2, a canonical neurorepellent, promotes lysosome biogenesis and augments autophagic flux to modulate immune responses in macrophages. In cancer cells, SLIT2 negatively regulates mTORC1 signaling to control cell growth.
- An immune-based tool platform for in vivo cell clearance
A tool platform that allows the exploration of immune-mediated cytotoxic therapies to target pathological cells in diseases beyond cancer.
- MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model
It is found that miR-93-5p decreases retinal neuron apoptosis through suppressing PDCD4 in acute ocular hypertension model, which indicates miR-93-5p as a therapeutic target of glaucoma.
- Toxicity of C9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags
Protein tags affect the toxicity of C9orf72-associated dipeptide repeat proteins and therefore should be avoided in preclinical models of C9orf72 ALS and FTD.
- Apolipoprotein E intersects with amyloid-β within neurons
Apolipoprotein E4, the most important genetic risk factor for Alzheimer's disease, is shown to internalize into neurons and intersect with amyloid-β in endosomes–autophagosomes of neurites and modulate intraneuronal amyloid-β-42.
- Preeclampsia promotes autism in offspring via maternal inflammation and fetal NFκB signaling
This study highlights elevated TNFα in maternal serum contributes to autism-like phenotypes in offspring exposed to preeclampsia and gives a therapeutic target to prevent it.
- Biallelic structural variations within FGF12 detected by long-read sequencing in epilepsy
This study demonstrates biallelic intragenic structural variations and a homozygous single-nucleotide variant in FGF12 cause epilepsy as a new loss-of-function mechanism of FGF12 in humans.