Newest Articles
- Convergent evolution and B-cell recirculation in germinal centers in a human lymph node
The study characterizes an ongoing immune response by sequencing B-cells from 10 germinal centers and finds diverse clonal patterns and convergent evolution, indicating re-engagement and rediversification of B-cell clones across GCs.
- p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons
This work shows a robust and stable aggrephagy regulation in mouse ESCs and ESC-derived neurons in absence of p62 and NBR1 functions.
- Tumor necrosis factor mediates USE1-independent FAT10ylation under inflammatory conditions
The finding of TNF-dependent FAT10ylation in the absence of USE1 identifies seven additional, so far unknown FAT10-reactive E2 conjugating enzymes.
- Allotopic expression of COX6 elucidates Atco-driven co-assembly of cytochrome oxidase and ATP synthase
Relocation of COX6 from nuclear to the mitochondrial genome helps unveil the role of Atco (Atp9–Cox6 complex) in coupling the biogenesis of cytochrome oxidase and ATP synthase in yeast mitochondria.
- c-JUN is a barrier in hESC to cardiomyocyte transition
The study reveals that knocking out c-JUN improves cardiomyocyte generation in humans by increasing chromatin accessibility and H3K4me3 modification on key genes regulating heart development. These findings shed new light on c-JUN's unexpected role in human cardiogenesis.
- A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance
Mechanistic characterization of a novel, lipophilic antifolate that suppresses growth of FPGS-deficient cells that are linked to methotrexate resistance and relapse in cancer patients.
- Whole genome sequencing of drug resistance Mycobacterium tuberculosis from extra-pulmonary sites
The article summarizes the characteristics of patients with drug resistance extra-pulmonary tuberculosis (DR-EPTB) and gene mutations of drug resistant Mycobacterium tuberculosis (DR-TB) from the patients with EPTB in a municipality of southwest China.
- Structural evidence for elastic tethers connecting separating chromosomes in crane-fly spermatocytes
Correlative live imaging with electron tomography provides evidence that physical filamentous connections extend between separating telomeres at all stages of anaphase.
- A Msp1-containing complex removes orphaned proteins in the mitochondrial outer membrane of T. brucei
Disruption of mitochondrial outer membrane protein biogenesis triggers a pathway leading to proteasomal degradation of orphan outer membrane proteins mediated by Msp1 and three interacting proteins.
- Neuroprotective effects of hepatoma-derived growth factor in models of Huntington’s disease
This study demonstrates that hepatoma-derived growth factor improves distinct Huntington’s disease phenotypes in cell culture and genetic mouse models.