Newest Articles
- Polo-like kinase-1 mediates hepatitis C virus-induced cell migration, a drug target for liver cancer
This study identifies PLK1 as a novel protein that promotes liver cancer in people with hepatitis C. The findings suggest a novel drug target for patients with liver cancer to reduce cancer spread and improve survival.
- Cell–cell interactions during the formation of primordial follicles in humans
This study revealed the presence of multinucleated syncytia and intercellular bridges in ovarian cords and highlighted the role of cell–cell interactions during primordial follicle formation in humans.
- Unique activities of two overlapping PAX6 retinal enhancers
A unique combination of high-resolution imaging and single-cell RNA sequencing in zebrafish reveals cell type-specific activities of developmental eye enhancers.
- Grp78 is required for intestinal Kras-dependent glycolysis proliferation and adenomagenesis
Heterozygous deletion of Grp78 reduces Apc–Kras-driven colorectal adenomagenesis. Apc–Kras-mutated cells rely on GLUT1 transporter for glycolysis, which is inhibited by Grp78 heterozygosity.
- Incomplete activation of Alyref and Gabpb1 leads to preimplantation arrest in cloned mouse embryos
This study shows that failed activation of developmentally required Alyref and Gabpb1 genes leads to the arrest of cloned mouse embryos.
- Convergent evolution and B-cell recirculation in germinal centers in a human lymph node
The study characterizes an ongoing immune response by sequencing B-cells from 10 germinal centers and finds diverse clonal patterns and convergent evolution, indicating re-engagement and rediversification of B-cell clones across GCs.
- p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons
This work shows a robust and stable aggrephagy regulation in mouse ESCs and ESC-derived neurons in absence of p62 and NBR1 functions.
- Tumor necrosis factor mediates USE1-independent FAT10ylation under inflammatory conditions
The finding of TNF-dependent FAT10ylation in the absence of USE1 identifies seven additional, so far unknown FAT10-reactive E2 conjugating enzymes.
- Allotopic expression of COX6 elucidates Atco-driven co-assembly of cytochrome oxidase and ATP synthase
Relocation of COX6 from nuclear to the mitochondrial genome helps unveil the role of Atco (Atp9–Cox6 complex) in coupling the biogenesis of cytochrome oxidase and ATP synthase in yeast mitochondria.
- c-JUN is a barrier in hESC to cardiomyocyte transition
The study reveals that knocking out c-JUN improves cardiomyocyte generation in humans by increasing chromatin accessibility and H3K4me3 modification on key genes regulating heart development. These findings shed new light on c-JUN's unexpected role in human cardiogenesis.