Newest Articles
- VDR is an essential regulator of hair follicle regression through the progression of cell death
This study investigates the role of VDR in the progression of catagen, and demonstrates that aberrant regression that ectopically prevents cell death impairs hair follicle regeneration, emphasizing the significance of regression in tissue homeostasis.
- Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface
The structure of RIPK2 kinase bound to the XIAP BIR2 domain reveals the essential role of the RIPK2 dimer in NOD2 signalling and explains the mechanism of anti-inflammatory drugs targeting this complex.
- Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation
SARS-CoV-2 exploits host lipid metabolism for its replication and pathogenesis. Blocking SREBPs prevents SARS-CoV-2–induced lipid remodeling, virus replication, cell death, and inflammatory mediators, suggesting SREBP as a potential host-derived antiviral target.
- A new ferrocene derivative blocks K-Ras localization and function by oxidative modification at His95
We report redox system regulates KRAS localization and activity via oxidation at His95 residue, and proposes a role of oncogenic K-Ras in the antioxidant-induced growth and metastasis of KRAS-driven cancers.
- Molecular mechanisms underlying totipotency
A review article summarizing recent findings related to totipotency in mammals, encompassing topics such as the epigenome and gene regulation in early embryos, in vitro totipotent-like cells, and somatic nuclear transfer.
- The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine
Arginine methyltransferase PRMT5 promotes select colonic goblet cell-associated gene programs and facilitates host defense against enteric pathogens.
- Alternative oxidase causes cell type- and tissue-specific responses in mutator mice
Expression of the alternative oxidase in mtDNA mutator mice improves their blood phenotype but enhances inflammatory and stress responses in skeletal muscle.
- LEF1 enhances β-catenin transactivation through IDR-dependent liquid–liquid phase separation
This research elucidates the correlation between liquid–liquid phase separation (LLPS) of LEF1 with β-catenin and their transcriptional activation function, offering a novel therapeutic approach for the treatment of colorectal cancer through LLPS.
- T cell differentiation drives the negative selection of pathogenic mitochondrial DNA variants
Fluorescently activated cell-sorting coupled with high-throughput single cell mtDNA sequencing reveals enhanced negative selection of pathogenic mtDNA variants in T cells, with more mature, memory cells exhibiting lower mutation levels than their naïve counterparts.
- Decoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinoma
Preclinical models demonstrate that obesity reprograms the pretumor or tumor cell and its micro- and macro-environments to drive cancer development via altered cellular metabolism, hormone dysregulation, inflammation, and microbial dysbiosis.