Newest Articles
- Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9–mediated genome engineering in HAP1 cells mimicking cancer profiles
The unintended 10q23.31 deletion frequency rises in HAP1 cells stressed during CRISPR-Cas9 engineering, leading to aberrant molecular and cellular changes resembling common cancer patient deletions.
- Patient-specific analysis of co-expression to measure biological network rewiring in individuals
Cosinet has the potential to empower personalized treatment by accurately quantifying the degree of rewiring in individual samples compared with reference conditions using mechanism-related differential co-expression sub-networks.
- Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure
We exposed pregnant female mice to neonicotinoid thiacloprid. We observed reproductive defects together with DNA methylation and histone H3K9me3 changes in the third-generation males.
- DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway
This study reveals that decreased DOCK1 in placental villi affects trophoblast function via the DUSP4-ERK pathway, providing insights into adverse pregnancy outcomes.
- Cristae dynamics is modulated in bioenergetically compromised mitochondria
Live-cell super-resolution nanoscopy reveals modulation of cristae dynamics in bioenergetically compromised mitochondria demonstrating that cristae morphology and dynamics are intricately connected.
- Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3
The study shows that Yap1 expression correlates with poor outcomes in human gastric cancer and causally contributes to disease progression in mice via cancer cell–intrinsic and –extrinsic mechanisms.
- Visualization of conformational transition of GRP94 in solution
SAXS, nsEM, and HDX-MS reveal that one extended and two compact conformations of GRP94 coexist in solution and that the binding and hydrolysis of ATP only drives the transition between the two compact conformations while leaving the extended population unaffected.
- PD-L1 regulates inflammatory programs of macrophages from human pluripotent stem cells
This study identified the novel role of immune checkpoint PD-L1 in inflammatory programs of macrophages.
- FAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon response
IKKβ-mediated phosphorylation of FAT10 dampens the antiviral type I interferon response by stabilizing OTUB1.
- DCAF14 regulates CDT2 to promote SET8-dependent replication fork protection
DCAF14 modulates CRL4CDT2-dependent turnover during DNA replication. Loss of DCAF14 causes nascent strand degradation due to excessive proteasomal turnover of SET8 by aberrant CDT2 activity.