Newest Articles
- Integrated analysis of RNA-seq datasets reveals novel targets and regulators of COVID-19 severity
This work observed differential expression of genes related to the endomembrane system, specific granules, T cell receptor complex, and SPI1 and TP53 target genes exclusively in severe COVID-19 patients.
- Drosophila MIC10b can polymerize into cristae-shaping filaments
DmMIC10b, the primary MIC10 orthologue in Drosophila, is crucial for MICOS stability and mitochondrial ultrastructure and exhibits a distinctive ability to form filaments, impacting mitochondrial cristae architecture.
- Single variant, yet “double trouble”: TSC and KBG syndrome because of a large de novo inversion
Short-read genome sequencing identified an 87-Mb inversion in a patient with atypical Tuberous sclerosis. The inversion disrupts TSC2 and ANKRD11, resulting in dual diagnosis of TSC/KBG syndromes.
- Absence of the RING domain in MID1 results in patterning defects in the developing human brain
Molecular and cellular phenotyping of human brain organoids carrying various MID1 mutations reveals an unexpected role of the composition of the MID1 isoform pool during early patterning processes.
- Reduced myeloid commitment and increased uptake by macrophages of stem cell–derived HPS2 neutrophils
Our current work uses iPSC-derived neutrophils to unveil novel reasons for the neutropenia found in HPS2 patients. HPS2 iPSC-derived neutrophils have lower myeloid commitment, and are actively phagocytosed by macrophages present in the iPSC cultures or healthy donor macrophages.
- Synaptobrevin2 monomers and dimers differentially engage to regulate the functional trans-SNARE assembly
This work demonstrates different factors controlling the synaptobrevin2 dimer-to-monomer ratio, which has ramifications in fusion pore stability.
- Spatiotemporal DNA methylation dynamics shape megabase-scale methylome landscapes
The guanine–cytosine content of genomic regions influences their spatial properties, resulting in various megabase-scale methylome patterns across different cell types.
- 2023 Reviewer Index
The LSA Editors thank these scientists for sharing their time and expertise while reviewing manuscripts in 2023. We sincerely appreciate their support.
- The LINC complex ensures accurate centrosome positioning during prophase
Centrosome positioning in prophase is essential for efficient spindle assembly. Here, we show that centrosome positioning requires LINC complex–mediated loading of dynein on the nuclear envelope.
- Accessory genes define species-specific routes to antibiotic resistance
In this study, we show how decision tree models can accurately predict the AMR phenotype, and this study highlights that resistance is a result of multi-gene interactions, which are often species-specific.