Newest Articles
- BRG1 HSA domain interactions with BCL7 proteins are critical for remodeling and gene expression
Interactions between the BRG1 HSA domain and the B-cell CLL/lymphoma 7 proteins facilitate BRG1-mediated chromatin remodeling and induce changes in the gene expression of essential biological pathways.
- AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation
This study shows that TPX2 co-overexpression in non-transformed human cells induces AurkA nuclear accumulation and promotes its non-mitotic oncogenic functions.
- Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteria
Whole-genome sequencing is used to discover novel potential mechanisms of antimicrobial resistance and mobile genetic elements in lactic acid bacteria and bifidobacteria from the agro-food chain.
- Dual function of Rab1A in secretion and autophagy: hypervariable domain dependence
Gyurkovska et al show that whereas both Rab1A and Rab1B regulate secretion, Rab1A-HVD enables it to localize to autophagosomes and regulate autophagy. This provides a mechanism for a dual functionality of a single Rab in two different cellular pathways.
- Tannins amount determines whether tannase-containing bacteria are probiotic or pathogenic in IBD
TA-induced microbial metabolite GA displays dual effects on IBD. GA exerts its function through two ways: influence bacteria penetration and directly affect epithelial cells. Interaction between diet and microbial enzyme is pivotal in affecting IBD.
- A novel hypervariable variable number tandem repeat in the dopamine transporter gene (SLC6A3)
This VNTR has a heterozygosity value of 0.93, forms G-tetrads, and is in low linkage disequilibrium with surrounding sequence, making it a new site for genetic analysis.
- ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells
ICOS signaling promotes T follicular regulatory cell differentiation during germinal center reaction safeguarding against autoantibody production.
- The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity
Magnesium (Mg2+) binding to the human mitochondrial RNA splicing 2 (MRS2) protein channel amino terminal domain disrupts homomeric interactions and inhibits mitochondrial Mg2+ uptake as a negative feedback mechanism.
- Expansion microscopy reveals subdomains in C. elegans germ granules
Visualising C. elegans germ granules using the super resolution technique expansion microscopy against the backdrop of proteome staining reveals granule ultrastructure.
- SRSF7 and SRSF3 depend on RNA sequencing motifs and secondary structures to regulate Microprocessor
Microprocessor cleaves pri-miRNAs to produce miRNAs. SRSF7 and SRSF3 interact with specific RNA elements in pri-miRNAs to modulate the cleavage of Microprocessor, thereby regulating miRNA biogenesis.