Newest Articles
- Dynamic changes of enhancer and super enhancer landscape in degenerated nucleus pulposus cells
Super-enhancers mediate inflammatory cascade and extracellular matrix remodeling in degenerated nucleus pulposus cells.
- The ubiquitin-like modifier FAT10 is degraded by the 20S proteasome in vitro but not in cellulo
The ubiquitin-like modifier FAT10 is degraded by the 20S proteasome in vitro, whereas FAT10 degradation depends on the 26S proteasome in cellulo, shown by impairing 26S function via Rpt2 knockdown.
- arfA antisense RNA regulates MscL excretory activity
Bacteria coordinate how they respond to translation and osmotic stress by using antisense RNA crosstalk between the genes involved in the respective stress response pathways.
- RopB represses the transcription of speB in the absence of SIP in group A Streptococcus
SIP-free RopB, in contrast to SpeB-inducing peptide (SIP)-bound RopB, is a transcriptional repressor of speB and mediates speB repression in the covS mutant.
- UPF3A is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells
We generated a new Upf3a-inducible knockout mouse model and showed that UPF3A does not repress expressions of NMD target genes in embryonic stem cells, somatic fibroblasts, and multiple tissues from adult mice.
- Bats experience age-related hearing loss (presbycusis)
Bats exhibited age-related hearing loss. Bats are exposed to immense conspecific noise, but the frequency-dependent hearing loss was not correlated to the noise.
- The role of the mitochondrial outer membrane protein SLC25A46 in mitochondrial fission and fusion
The mitochondrial outer membrane protein SLC25A46 localizes to mitochondrial fusion and fission sites, and loss of function alters mitochondrial morphology and oligomerization states of MFN2 and OPA1.
- The association of lipid transfer protein VPS13A with endosomes is mediated by sorting nexin SNX5
Binding of sorting nexin SNX5 to the VAB domain of VPS13A mediates its recruitment to membrane contact sites between SNX5-containing endosomal membranes, mitochondria, and ER.
- Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1
The SARS-CoV-2 Omicron BA.1 variant of concern is highly resistant against exogenous interferons, suggesting that effective innate immune evasion contributed to its success.
- The role of Limch1 alternative splicing in skeletal muscle function
This works identifies a novel, alternatively spliced isoform of LIMCH1, that is, developmentally regulated and specific to skeletal muscle. Knocking out the six skeletal muscle–specific exons of LIMCH1 leads to impaired skeletal muscle function in vivo and ex vivo.