Newest Articles
- EZH2 controls epicardial cell migration during heart development
EZH2 influences epicardial cell migration into the myocardium via TIMP3-dependent fine tuning of basement membrane degradation, which leads to cardiac malformations and embryonic lethality.
- Rapid and precise genotyping of transgene zygosity in mice using an allele-specific method
A novel, precise, rapid, and generalizable method to determine transgene zygosity in mice by allele-specific restriction enzyme digestion of PCR products from transgenes or homologous endogenous genes.
- Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma
Glioma patients often relapse because of resistance to radiation therapy. The transfer of the metabolic enzyme NAMPT via microvesicles and the accompanying elevated levels of NAD are found to be a mechanism by which glioma cells become resistant to radiation.
- Retinitis pigmentosa–associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule cells
This study shows that Prpf8 mutations associated with human retinal degeneration in mice alter circRNA expression in cerebellar granule cells and induce their apoptosis.
- An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity
This work describes how a mutation affecting mitochondrial metabolism in a sarcoma model induces protective immunity against the tumor and how this result might be relevant for sarcoma patients.
- Multidimensional conservation analysis decodes the expression of conserved long noncoding RNAs
The authors demonstrate the transcriptional codes that govern the expression of conserved long noncoding RNAs through multi-dimensional conservation analysis.
- Validating organoid-derived human intestinal monolayers for personalized therapy in cystic fibrosis
Ussing chamber studies of intestinal organoid monolayers compare favorably to established preclinical tools to assess individual responses to CFTR modulator drugs in people with cystic fibrosis.
- Dynamic changes of enhancer and super enhancer landscape in degenerated nucleus pulposus cells
Super-enhancers mediate inflammatory cascade and extracellular matrix remodeling in degenerated nucleus pulposus cells.
- The ubiquitin-like modifier FAT10 is degraded by the 20S proteasome in vitro but not in cellulo
The ubiquitin-like modifier FAT10 is degraded by the 20S proteasome in vitro, whereas FAT10 degradation depends on the 26S proteasome in cellulo, shown by impairing 26S function via Rpt2 knockdown.
- arfA antisense RNA regulates MscL excretory activity
Bacteria coordinate how they respond to translation and osmotic stress by using antisense RNA crosstalk between the genes involved in the respective stress response pathways.