Newest Articles
- The Golgi checkpoint: Golgi unlinking during G2 is necessary for spindle formation and cytokinesis
This work shows that Golgi complex disassembly during G2 is required for spindle formation and cytokinesis, thus revealing novel regulatory mechanisms that control the fidelity of mitosis.
- Genetic ablation of Immt induces a lethal disruption of the MICOS complex
A new conditional mouse model deleting Immt/MIC60 reveals the necessity of this protein in vivo and provides an important resource for future research into the mitochondrial MICOS complex.
- Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity
Cavefish evolved protection from starvation-induced liver damage through a reduction in fatty acid uptake regulated by FATP2, a mechanism conserved through 400 million years of animal evolution.
- Interrogating endothelial barrier regulation by temporally resolved kinase network generation
This study introduces TREKING, a methodology for broadly interrogating kinases to elucidate time-resolved functional kinase signaling networks that drive endothelial barrier disruption and recovery.
- C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis
C5aR antagonist and MEK inhibition combination therapy changes the tumor microenvironment and induces ongoing tumor cell phagocytosis.
- Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex
The study reveals how KRAS mutations disrupt LZTR1-mediated KRAS degradation, shedding light on potential mechanisms in oncogenesis.
- Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life
The recently discovered HAPSTR1 protein facilitates a nuclear quality control pathway essential for mammalian life.
- Phosphorylation of Rec8 cohesin complexes regulates mono-orientation of kinetochores in meiosis I
Phosphorylation of the Rec8 cohesin complexes plays a crucial role in establishing mono-orientation of sister kinetochores which is important for reductional division in meiosis I in fission yeast.
- Systemic metabolic depletion of gut microbiome undermines responsiveness to melanoma immunotherapy
Relationship between gut microbiome composition and immunotherapy efficacy.
- Pip5k1γ regulates axon formation by limiting Rap1 activity
Pip5k1γ is shown to regulate axon formation as a negative feedback signal. Impairing its function or manipulating membrane tension by osmotic shock induces the formation of supernumerary axons by hyper-activation of C3G and Rap1.