Newest Articles
- SF3B1 mutation–mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia
Understanding the pathogenic mechanisms of SF3B1 mutation can help unravel their contribution in patients’ worse prognosis. The cytotoxic effects and delayed leukemic infiltration induced by H3B-8800 support the potential use of SF3B1 inhibitors as a novel therapy in CLL.
- Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration
Parenchymal border macrophages’ (PBMs) function impedes tau pathology and tau-mediated neurodegeneration, whereas tau pathology promotes PBM dysfunction associated with impaired CSF flow.
- ATP-independent substrate recruitment to proteasomal degradation in mycobacteria
Mycobacterial proteasomes ensure survival during stress by recruiting substrates for degradation via ring-shaped activators. This study elucidates the mechanism of ATP-independent substrate recruitment through the bacterial proteasome activator (Bpa), revealing the determinants for substrate recognition and efficient degradation.
- Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme
The noncanonical inflammasome generates p32/p9 and p34/p9 active caspase-4 species via dimerisation and autocleavage; both species cleave GSDMD to induce pyroptosis, whereas p34/p9 matures IL-1β.
- High-resolution kinetic characterization of the RIG-I-signaling pathway and the antiviral response
This study takes a comprehensive approach to understand the dynamics of the cell-intrinsic response towards virus infection and how viruses actively modulate this.
- De novo network analysis reveals autism causal genes and developmental links to co-occurring traits
In this study, we provide a biological argument for looking at an autistic individual’s phenotype as being related to their combined genetic risk for different clusters of traits.
- IKBKB reduces huntingtin aggregation by phosphorylating serine 13 via a non-canonical IKK pathway
Early exposure of RA induced altered expressions of Wnt-related genes and subsequent osteogenic differentiation in embryonic mouse craniofacial prominences in a spatiotemporal-dependent manner.
- Generating fast-twitch myotubes in vitro with an optogenetic-based, quantitative contractility assay
We here describe an in vitro contractility assay to control fiber-type composition in muscle cultures.
- HGF/c-Met/β1-integrin signalling axis induces tunneling nanotubes in A549 lung adenocarcinoma cells
Interactions between hepatocyte growth factor (HGF), the c-Met receptor, and β1-integrin induce tunneling nanotubes in A549 cells; paxillin and the downstream MAPK and PI3K pathways and the Arp2/3 complex drive HGF-induced TNT formation.
- Macrophage Sult2b1 promotes pathological neovascularization in age-related macular degeneration
Sult2b1 deficiency attenuates pathologic neovascularization by inhibiting M2 macrophage polarization and promoting cholesterol efflux via the LXR–ABCA1/G1 pathway.