Newest Articles
- Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes
Biochemical and genetic experiments identify distinct roles of the two domains of Tim50 in the intermembrane space during translocation of proteins into the mitochondria via the TOM and TIM23 complexes.
- Themis controls T cell activation, effector functions, and metabolism of peripheral CD8+ T cells
Acute deletion of Themis in peripheral CD8+ T cells shows Themis controls T cell receptor signaling, effector functions, and metabolism. Signal cascade adaptation occurred with chronic Themis deletion.
- Glioblastoma cellular MAP4K1 facilitates tumor growth and disrupts T effector cell infiltration
MAP4K1 acts as a cancer cell-intrinsic driver of tumorigenesis and immune evasion in human gliomas, specifically glioblastoma multiforme, by modulating cytokine–chemokine signaling networks.
- Cell-free chromatin immunoprecipitation to detect molecular pathways in heart transplantation
Cell-free DNA chromatin immunoprecipitation detects molecular pathways and profiles the sources of tissue injury in heart transplant patients.
- SiR-DNA/SiR–Hoechst-induced chromosome entanglement generates severe anaphase bridges and DNA damage
Live-cell imaging-based study calls for caution when using SiR-DNA, as it induces chromosome entanglement that severely impairs sister chromatid segregation in mitosis, consequently causing DNA damage.
- MAST4 promotes primary ciliary resorption through phosphorylation of Tctex-1
The mechanism that underlies cilium resorption is not well understood. This study reveals the microtubule-associated serine/threonine kinase family member 4 (MAST4) is a novel kinase that promotes ciliary resorption by localizing ciliary base-phosphorylation of Tctex-1 at Thr94 and its downstream effectors.
- High-quality single-cell transcriptomics from ovarian histological sections during folliculogenesis
Quantitative RNA-sequencing method for single cells isolated from alcohol- and formalin-fixed tissue sections discovers new relationships between histology and transcriptome during folliculogenesis.
- RB loss sensitizes cells to replication-associated DNA damage after PARP inhibition by trapping
After PARP inhibition by trapping, cells lacking the RB tumor suppressor experience persistent replication stress and genomic instability that compromise cell viability.
- Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
COVID-19 still poses a major health threat with worldwide ongoing hospitalizations and mortality. Aberrant antibody responses are a crucial cause of development of severe COVID-19 by inducing hyperinflammation, edema, and thrombus formation. Here, we identified entospletinib as a promising therapeutic candidate against severe COVID-19.
- Control of Paneth cell function by HuR regulates gut mucosal growth by altering stem cell activity
HuR stimulates the activity of intestinal stem cells by enhancing Paneth cell function via activation of mitochondrial metabolism, thus promoting renewal of the intestinal mucosa.