Newest Articles
- Causal links of α-thalassemia indices and cardiometabolic traits and diabetes: MR study
Causal MR study links α-thalassemia-related erythrocyte traits to cardiometabolic risks and diabetes susceptibility in Taiwan.
- Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo
SLAMF1-derived peptide P7 inhibits TLR4-mediated signaling and prevents animal death in mice subjected to LPS shock by blocking TIRAP–MyD88 interaction and TRAM recruitment to TLR4.
- scFseCluster: a feature selection-enhanced clustering for single-cell RNA-seq data
This study presents a novel computational framework scFseCluster for scRNA-seq clustering analysis. Particularly, an excellent feature selection algorithm FSQSSA was encapsulated in the scFseCluster platform, which achieves optimal gene sets for clustering tasks.
- Cost-effective DNA methylation profiling by FML-seq
A low-cost, high-throughput method for genome-wide DNA methylation profiling based on methylation-specific restriction digestion and sequencing.
- TRIM25 targets p300 for degradation
Here, it is shown that the E3 protein TRIM25 targets the transcriptional co-activator p300 in an ubiquitin-independent manner for proteasomal degradation involving the motor protein dynein.
- KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas
KCNQ3, a potassium channel, is frequently genetically altered in gastro-oesophageal adenocarcinomas and found to be significantly associated with WNT and MYC activity, and cellular proliferation.
- Comparative analysis of bioinformatics tools to characterize SARS-CoV-2 subgenomic RNAs
This study compares the performances of three different software in the identification of canonical and noncanonical sgRNAs in amplicon data sequenced with Illumina MiSeq in 250-bp paired ends.
- Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes
Biochemical and genetic experiments identify distinct roles of the two domains of Tim50 in the intermembrane space during translocation of proteins into the mitochondria via the TOM and TIM23 complexes.
- Themis controls T cell activation, effector functions, and metabolism of peripheral CD8+ T cells
Acute deletion of Themis in peripheral CD8+ T cells shows Themis controls T cell receptor signaling, effector functions, and metabolism. Signal cascade adaptation occurred with chronic Themis deletion.
- Glioblastoma cellular MAP4K1 facilitates tumor growth and disrupts T effector cell infiltration
MAP4K1 acts as a cancer cell-intrinsic driver of tumorigenesis and immune evasion in human gliomas, specifically glioblastoma multiforme, by modulating cytokine–chemokine signaling networks.