Newest Articles
- Correction: Expansion microscopy reveals subdomains in C. elegans germ granules
Correction to Materials and Methods.
- Determinants of cytoplasmic microtubule depolymerization during ciliogenesis in Chlamydomonas
Chemically induced deciliation previously shown to induce cytoplasmic microtubule depolymerization occurs independently of ciliary loss. Furthermore, immediate ciliogenesis can occur in the presence of polymerized cytoplasmic microtubules.
- Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A
A previously uncharacterized protein, FAM53C, is identified as a binding partner for the kinase DYRK1A involved in numerous neurodevelopmental disorders, such as Down syndrome and autism spectrum disorder. FAM53C anchors the DYRK1A-DCAF7 complex within the cell cytoplasm in a kinase-inactive state.
- Toward an understanding of glucose metabolism in radial glial biology and brain development
We review the literature exploring the role of glycolysis and glucose metabolism in cortical development and discuss recent advances and future directions to better understand metabolic disease and neurodevelopment disorders.
- Activation of the JNK/COX-2/HIF-1α axis promotes M1 macrophage via glycolytic shift in HIV-1 infection
This study reveals JNK/COX-2/HIF-1α axis activation enhances glycolysis, promoting M1 polarization in HIV-1–infected macrophages, offering a novel approach to AIDS-related inflammation.
- Functional plasticity in chromosome–microtubule coupling on the evolutionary time scale
We identify a lethal mutation in a subunit of the Dam1 complex, a chromosome–microtubule coupler in Saccharomyces cerevisiae with point centromeres. However, this mutation is tolerated in organisms with longer regional centromeres, possibly by employing more microtubules to capture each chromosome.
- Improving lysosomal ferroptosis with NMN administration protects against heart failure
NMN supplementation affects lysosome-mediated ferroptosis, leading to improved autophagy, thereby reducing heart failure and prolonging the lifespan in mitochondrial translation-deficient mice.
- Regulation of alternative splicing and polyadenylation in neurons
Neurons generate numerous cell-specific isoforms of genes that are expressed more broadly. Here, we review mechanisms that generate neural-specific alternative splicing and 3′UTRs and their biological impacts on the nervous system.
- FAM111A regulates replication origin activation and cell fitness
Tight control of FAM111A is essential to maintain cellular homeostasis: FAM111A depletion impairs DNA replication, whereas its unrestrained expression leads to ssDNA formation and cell death.
- MUC13 drives cancer aggressiveness and metastasis through the YAP1-dependent pathway
This study reveals that MUC13 plays a critical role in the metastasis-associated processes via interaction with YAP1 and nuclear translocation of the YAP1-mediated survival complex and a biochemical intervention that interferes with MUC13–YAP1 complex formation can help develop new therapeutics.