Newest Articles
- Biogenesis, inheritance, and 3D ultrastructure of the microsporidian mitosome
Quantitative electron and light microscopy combined with bioinformatics reveal that microsporidian mitosomes grow and divide incrementally and are inherited at the microsporidian centrosome (spindle pole body), whereas mitochondrial dynamins participate in mitosome division.
- Synergistic roles of tristetraprolin family members in myeloid cells in the control of inflammation
Simultaneous deficiency of three tristetraprolin family members in myeloid cells resulted in severe inflammation in mice, suggesting that these three proteins act together to prevent inflammation.
- Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variants
Mechanisms and consequences of POLE mutations in human cancers.
- APR-246 increases tumor antigenicity independent of p53
Michels, Venkatesh et al demonstrate that APR-246, a small molecule Michael acceptor, enhances tumor immunogenicity. Combination of APR-246 with immune modulation enhances antitumor responses. APR-246, initially described as a P53 stabilizer, induces immunogenicity irrespective of the tumor’s p53 status.
- Automated staging of zebrafish embryos with deep learning
Introducing KimmelNet: A deep learning model that accurately stages populations of zebrafish embryos from 2D brightfield images, offering a rapid and objective alternative to manual observations.
- NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma
The hyperactivation of Src tyrosine kinase in glioblastoma leads to the constitutive stabilization and activation of NRF2, thus causing resistance to ionizing radiation-induced ferroptosis.
- MICA: a multi-omics method to predict gene regulatory networks in early human embryos
Our comparative analysis of gene regulatory network predictions defines a pipeline to infer transcription factor–target gene regulatory interactions in early human embryos. Mutual information refined by chromatin accessibility allowed us to construct the first network during early human development.
- Correction: Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops
Endogenous PRC1–mediated chromatin compaction and clustering of polycomb target loci are reversibly perturbed in mESCs by the addition of 1,6 hexandiol.
- Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid
TMEM107 plays a crucial role in early vertebrate eye development and ciliogenesis in the differentiating retina, and its absence leads to eye defects and impaired retinal organoid formation.
- Pathway-driven analysis of synthetic lethal interactions in cancer using perturbation screens
This study introduces a signaling pathway-informed computational approach to identify synthetic lethal (SL) interactions in various cancer types, uncovering potential targeted therapies for specific genetic alterations.