Newest Articles
- Subdomains of the Helicobacter pylori Cag T4SS outer membrane core complex exhibit structural independence
Structural and proteomic analyses of H. pylori Cag T4SSs purified from deletion mutants highlight the unexpected structural independence between the OMC and PR, two major subdomains of this complex.
- Frataxin deficiency shifts metabolism to promote reactive microglia via glucose catabolism
Frataxin depletion triggers reactive microglia with increase glucose catabolism. Butyrate treatment reinstates immunometabolic balance, potentially offering neuroprotection.
- Autocrine VEGF drives neural stem cell proximity to the adult hippocampus vascular niche
Autocrine VEGF signaling is necessary to maintain adult neural stem and progenitor cell proximity to blood vessels in the adult hippocampus and promotes their motility or adhesion.
- Nr1h4 and Thrb ameliorate ER stress and provide protection in the MPTP mouse model of Parkinson’s
The study highlights the potential of GW4064 and T3 in ameliorating PD as the combination of ligands shows promising effects in reducing ER stress, maintaining mitochondrial activity, and protecting dopaminergic neurons in the MPTP mouse model of PD.
- Structural basis of translation inhibition by a valine tRNA-derived fragment
We analyzed three structures of Val-tRF-30S ribosomal complexes, which revealed the mechanism by which val-tRF inhibits protein translation. The mechanism includes the binding of val-tRNA to the decoding site, inhibiting the binding of tRNA-mRNA, and inhibiting the binding of aIF1A.
- Sensitive circulating tumor DNA–based residual disease detection in epithelial ovarian cancer
Tumor-guided circulating tumor DNA analysis achieves high sensitivity and specificity for post-operative surveillance of epithelial ovarian cancer, including the first test of assays targeting thousands of mutations.
- DEFA1A3 DNA gene-dosage regulates the kidney innate immune response during upper urinary tract infection
α-Defensin 1-3 (DEFA1A3) are host antimicrobial peptides with potent innate immune functions during infectious diseases. Differential UTI risk has been linked to DEFA1A3 DNA polymorphisms. This study elucidates mechanisms of DEFA1A3 gene dose–dependent protection against UTI pathogenesis.
- Acetylation of Rec8 cohesin complexes regulates reductional chromosome segregation in meiosis
Meikin-dependent acetylation of Rec8 cohesin complexes at centromeres cooperates with the canonical cohesin acetylation to establish reductional chromosome segregation in meiosis in fission yeast.
- Differential effects of translation inhibitors on Plasmodium berghei liver stage parasites
Five diverse translation inhibitors are tested at equivalent effective concentrations, revealing that translation inhibition efficacy does not determine the Plasmodium berghei liver stage antiplasmodial efficacy.
- ETV2 induces endothelial, but not hematopoietic, lineage specification in birds
ETV2, a master regulator of blood and vessel development in mammals, is deleted in bird genomes, and exogenous ETV2 induces endothelial lineage specification in nascent chicken mesoderm.