Newest Articles
Research Article
Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populationsDeleterious variants in the DNA damage repair system can cause genome instability and increase cancer risk. The highly ethnic-specific DDR deleterious variation from this study suggests its potential relationship with different disease susceptibility in ethnic human populations.
Research Article
Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock responseHikeshi mediates proper nucleocytoplasmic distribution of HSP70, which is important for regulating of HSF1 activity and nuclear proteostasis, and adaptive response to heat shock.
Research Article
DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITFOur study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.
Research Article
Expression regulation of genes is linked to their CpG density distributions around transcription start sitesIn this work, we performed a gene classification which revealed that different gene clusters harbor distinct gene regulatory mechanisms as well as epigenetic mark and expression variations in tumorigenesis.
Research Article
The HDL particle composition determines its antitumor activity in pancreatic cancerThe authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.
Research Article
Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagyWe describe a fully new remodeling event of the nuclear envelope surrounding the nucleolus: it partitions into its regular contact with the vacuole and a dramatic internalization of globular cytoplasmic portions within the nucleus.
Research Article
C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neuronsExtracellularly delivered poly-GAs are internalised into astrocytes via an endocytosis-dependent pathway and then spread to motor neurons, implying non-cell autonomous mechanisms in C9ORF72-ALS/FTD.
Research Article
Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmissionThis work shows that Plasmodium SAS4 is a part of the basal body and outer centriolar MTOC but not essential for male gamete formation.
Research Article
OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infectionMycobacteria up-regulate host kinase OXSR1 preventing potassium efflux and inflammasome activation. Depletion or inhibition of OXSR1 potentiates inflammasome activation and decreases bacterial burden.
Research Article
Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infectionA system-level up-regulation of OXPHOS and glycolysis could play a role in latent reservoir dynamics and immunosenescence in HIV-1–infected individuals with long-term successful therapy.
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