Newest Articles
Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egressPoxvirus extracellular virions are critical for virus virulence. This study shows that multivesicular bodies serve as a major cellular source of membrane for their formation and spread.
A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolismProtein kinase D3 (PKD3) regulates hepatic metabolism in a PKA-dependent manner and reveals many other putative PKD3 targets in the liver.
HCV poly U/UC sequence–induced inflammation leads to metabolic disorders in vulvar lichen sclerosisMulti-omics analysis reveals the elevation of HCV poly U/UC sequences, which induces abnormal inflammation and related metabolic disorder in vulvar lichen sclerosis.
Profiling chromatin accessibility responses in human neutrophils with sensitive pathogen detectionATAC-seq reveals unique neutrophil chromatin architecture changes in response to different stimuli before transcriptional activation, possibly regulating downstream gene expression.
Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in DrosophilaEdem1, an endoplasmic reticulum-resident protein, acts in the fat body to regulate insulin signalling and metabolic status in Drosophila, which aids in survival against nutrient deprivation.
Dissection-independent production of Plasmodium sporozoites from whole mosquitoesOvercoming limitations of traditional dissection-dependent methods for malarial sporozoite isolation from mosquitoes, a new dissection-free method is presented that yields pure, infective sporozoites.
DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosisDNA damage due to impairment of DNA damage repair functions in NSCs is carried over to neurons and triggers early-stage YAP-dependent neuronal necrosis (TRIAD) amplifying a chain of necrosis in FTLDs.
IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infectionIL-13 is tissue protective during acute lung injury caused by nematode migration and specifically regulates type 2 epithelial cell effector functions.
Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivoExogenous amyloid beta peptides cause distinct transcriptomic responses in microglia cultures that are not fully replicated in an amyloid mouse model or identified microglial subpopulations in vivo.
