Newest Articles
Lung macrophages utilize unique cathepsin K–dependent phagosomal machinery to degrade intracellular collagenThis study provides a comprehensive map of how peritoneal, lung, and brain tissue environment shapes phagosomal composition, revealing cathepsin K as the main peptidase in the intracellular destruction of collagen, which is mainly active in lung macrophages.
Meiotic DNA exchanges in C. elegans are promoted by proximity to the synaptonemal complexExchanges between DNA molecules during meiosis are tightly controlled. This work shows that the synaptonemal complex is instrumental in regulating meiotic exchanges both between the parental chromosomes and between the sister chromatids.
The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complexThe GET pathway promotes anchoring of the Ppg1-Far phosphatase complex to the ER membrane, contributing to initiation of Atg32-mediated mitochondria-specific autophagy in budding yeast.
SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β–induced synaptic pathologyThe protein sorting receptor SorCS1 shields the synapse organizer β-neurexins from amyloid-β oligomers (AβOs) to alleviate AβO-induced synaptic pathology.
Multiple phosphorylation of the Cdc48/p97 cofactor protein Shp1/p47 occurs upon cell stress in budding yeastThis study shows that phosphorylation of the yeast p97/Cdc48 adaptor protein Shp1 is enhanced upon multiple stresses, a process regulated by both Mpk1 kinase and PP1 phosphatase.
- 2022 Reviewer Index
The LSA Editors thank these scientists for sharing their time and expertise while reviewing manuscripts in 2022. We sincerely appreciate their support.
S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activationThis study shows that S417 of STIM1 plays an essential role in STIM1 C-terminus–Orai1 interaction and CRAC channel activation. It also presents new findings about 2-APB’s action on CRAC channel, which provides a tool for better understanding of SOCE activation.
Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2Cholesterol binds to the GlyT2 SLC6 transporter, enhancing the effect of bioactive lipid analgesics, providing new therapeutic avenues to treat neuropathic pain and target SLC6 transporters.
Structural and functional characterization of TraI from pKM101 reveals basis for DNA processingCharacterization of relaxase TraI from pKM101 highlights large conformational changes upon DNA binding, and unlike previous reports shows similar behavior as its homologs from the R388 and F plasmids.
An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinomaMETH use is associated with a higher incidence of hepatocellular carcinoma (HCC) in METH abusers and rehabilitees. METH exposure promotes HCC progression by ROS-mediated activation of the Ras/MEK/ERK signaling pathway. Clearance of ROS by NAC abolishes METH-induced HCC progression.
