Newest Articles
Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolutionGenome-wide analysis of R-loop alterations in U2OS cells deficient of DDX5, XRN2, and PRMT5 identify >50,650 DRIP-seq peaks spanning ∼4.5% of the genomic sequence. R-loops near TSS generated intergenic antisense transcription.
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortalityAffinity-based proteomics assays identify particular profiles of the circulating histidine-rich glycoprotein to increase with age and elevated levels to indicate a higher risk of all-cause mortality.
Mitochondrial spongiotic brain disease: astrocytic stress and harmful rapamycin and ketosis effectAstrocyte-specific mtDNA depletion causes spongiotic encephalopathy, aggravated by ketogenic diet or rapamycin. Astrocytes, but not neurons, drive mitochondrial integrated stress response in the CNS.
A time-resolved interaction analysis of Bem1 reconstructs the flow of Cdc42 during polar growthA temporal dissection correlates changes in composition and architecture of the interaction network of Bem1 with changes in cellular morphology and the activities of its binding partners.
CYP20-3 deglutathionylates 2-CysPRX A and suppresses peroxide detoxification during heat stressPosttranslational modification by a reduced glutathione determines distinctive quaternary structures and functions between two 2-cysteine peroxiredoxin A and B in the chloroplasts.
CryoEM structure of Drosophila flight muscle thick filaments at 7 Å resolutionRelaxed thick filaments from Drosophila flight muscle show disordered myosin heads, a ribbon arrangement of myosin tails and a novel protein, stretchin-klp, on the filament surface.
An evolutionary approach to systematic discovery of novel deubiquitinases, applied to LegionellaThe analysis of the relationships between different deubiquitinase classes leads to the definition of an aromatic “gatekeeper” motif that distinguishes DUBs from other cysteine proteases and helps to predict new bacterial DUBs.
Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1high memory phenotype CD4 T cellsPD-1high memory CD4 T cells are pathogenic in autoimmune disease; here they show their expression of Egr2 is defective in rheumatoid arthritis and Egr2 & 3 control their inflammation and homeostasis.
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cellsThe spike protein S of SARS-CoV-2 is activated by TMPRSS2 and furin. Inhibition of either one of these proteases can render the S protein unable to mediate virus entry and, therefore, provides a promising approach for COVID-19 treatment.
BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetesThis study reports that BH4 activates CaMKK2/PGC-1α; signaling pathway and has a therapeutic effect on diabetic cardiomyopathy.
