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Newest Articles

  • Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain
    Open Access
    Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain

    Camilla TO Benfield, Farrell MacKenzie, Markus Ritzefeld, Michela Mazzon, Stuart Weston, Edward Tate, Boon Han Teo, Sarah E Smith, Paul Kellam, Edward C Holmes, Mark Marsh

    Camilla TO Benfield ... Mark Marsh

    Published 11 December 2019

    Comparative analysis reveals adaptive evolution of bat IFITMs and a naturally polymorphic site within the conserved CD225 domain that affects S-palmitoylation and antiviral function of bat IFITM3.

  • Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis
    Open Access
    Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis

    Robert Brenig, Oltin T Pop, Evangelos Triantafyllou, Anne Geng, Arjuna Singanayagam, Christian Perez-Shibayama, Lenka Besse, Jovana Cupovic, Patrizia Künzler, Tuyana Boldanova, Stephan Brand, David Semela, François HT Duong, Christopher J Weston, Burkhard Ludewig, Markus H Heim, Julia Wendon, Charalambos G Antoniades, Christine Bernsmeier

    Robert Brenig ... Christine Bernsmeier

    Published 10 December 2019

    Immune dysfunction determines morbidity and mortality in liver cirrhosis. Distinct AXL-expressing circulating monocytes, which regulate antimicrobial responses, expand with progression of the disease.

  • MERLIN: a novel BRET-based proximity biosensor for studying mitochondria–ER contact sites
    Open Access
    MERLIN: a novel BRET-based proximity biosensor for studying mitochondria–ER contact sites

    Vanessa Hertlein, Hector Flores-Romero, Kushal K Das, Sebastian Fischer, Michael Heunemann, Maria Calleja-Felipe, Shira Knafo, Katharina Hipp, Klaus Harter, Julia C Fitzgerald, Ana J García-Sáez

    Vanessa Hertlein ... Ana J García-Sáez

    Published 9 December 2019

    MERLIN is a novel biosensor that generates a BRET signal with a signal-to-noise ratio that is sufficient to enable sensing the proximity between the mitochondria and the ER without forcing interaction or establishing artificial connections at the MERCs.

  • Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt<sup>+</sup> T cells
    Open Access
    Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells

    Mari Tenno, Alicia Yoke Wei Wong, Mika Ikegaya, Eiji Miyauchi, Wooseok Seo, Peter See, Tamotsu Kato, Takashi Taida, Michiko Oishi-Ohno, Hiroshi Ohno, Hideyuki Yoshida, Florent Ginhoux, Ichiro Taniuchi

    Mari Tenno ... Ichiro Taniuchi

    Published 9 December 2019

    Loss of Runx/Cbfβ complexes during DC development leads to a loss of gut CD103+CD11b+ cDC2s, which was accompanied with impaired differentiation of both Rorγt+ Th17 cells and type 3 Rorγt+ Treg cells.

  • A comprehensive resource for retrieving, visualizing, and integrating functional genomics data
    Open Access
    A comprehensive resource for retrieving, visualizing, and integrating functional genomics data

    Matthias Blum, Pierre-Etienne Cholley, Valeriya Malysheva, Samuel Nicaise, Julien Moehlin, Hinrich Gronemeyer, Marco Antonio Mendoza-Parra

    Matthias Blum ... Marco Antonio Mendoza-Parra

    Published 9 December 2019

    This study presents qcGenomics, a user-friendly online resource for ultrafast retrieval, visualization, and comparative analysis of tens of thousands of genomics datasets to gain new functional insight from global or focused multi-dimensional data integration.

  • TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life
    Open Access
    TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life

    Etienne Eschenbrenner, Stéphanie Jouannet, Denis Clay, Joëlle Chaker, Claude Boucheix, Christel Brou, Michael G Tomlinson, Stéphanie Charrin, Eric Rubinstein

    Etienne Eschenbrenner ... Eric Rubinstein

    Published 2 December 2019

    This study demonstrates that the tetraspanins Tspan5 and Tspan15 which directly associate with the metalloprotease ADAM10 have an opposite impact on its endocytosis and half-life.

  • Phenotypic proteomic profiling identifies a landscape of targets for circadian clock–modulating compounds
    Open Access
    Phenotypic proteomic profiling identifies a landscape of targets for circadian clock–modulating compounds

    Sandipan Ray, Radoslaw Lach, Kate J Heesom, Utham K Valekunja, Vesela Encheva, Ambrosius P Snijders, Akhilesh B Reddy

    Sandipan Ray ... Akhilesh B Reddy

    Published 2 December 2019

    This study provides comprehensive insights into the mechanism of action and cellular effects of circadian period–modulating compounds, which is critical for clearly defining molecular targets to modulate daily rhythms for therapeutic benefit.

  • Evaluation of colorectal cancer subtypes and cell lines using deep learning
    Open Access
    Evaluation of colorectal cancer subtypes and cell lines using deep learning

    Jonathan Ronen, Sikander Hayat, Altuna Akalin

    Jonathan Ronen ... Altuna Akalin

    Published 2 December 2019

    A deep learning approach refines the state-of-the-art subtypes of colorectal cancer and evaluates the fidelity of cell lines that model cancer.

  • CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation
    Open Access
    CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation

    Evangelia Chavdoula, David M Habiel, Eugenia Roupakia, Georgios S Markopoulos, Eleni Vasilaki, Antonis Kokkalis, Alexander P Polyzos, Haralabia Boleti, Dimitris Thanos, Apostolos Klinakis, Evangelos Kolettas, Kenneth B Marcu

    Evangelia Chavdoula ... Kenneth B Marcu

    Published 2 December 2019

    IKKα is an NSCLC suppressor and its loss in mouse AT-II lung epithelial cells or in human NSCLC lines increased urethane-induced adenoma growth and xenograft burdens, respectively. IKKα loss can up-regulate HIF-1α, enhancing tumor growth under hypoxia.

  • ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival
    Open Access
    ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival

    Avery Van Duzer, Sachiko Taniguchi, Ajit Elhance, Takahiro Tsujikawa, Naoki Oshimori

    Avery Van Duzer ... Naoki Oshimori

    Published 2 December 2019

    ADAP1, a GTPase-activating protein (GAP) for the small GTPase ARF6, is a strong predictor of poor survival in early-stage squamous cell carcinoma patients and a critical mediator of TGF-β-induced invasive cell migration by facilitating basement membrane breakdown.

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Issue Cover

Current Issue

Volume 2, No. 5
October 2019
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  • MMP9 in breast cancer anti-metastatic therapy
  • GAK regulates Na+/K+-ATPase
  • TRAIL-induced signaling response variation and resistance
  • In vitro education of human natural killer cells by KIR3DL1
  • Megakaryocytes migrate by membrane extrusion
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