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Newest Articles

  • Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations
    Open Access

    Research Article

    Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations

    Zixin Qin, Teng Huang, Maoni Guo, San Ming Wang

    Zixin Qin ... San Ming Wang

    Published 20 May 2022

    Deleterious variants in the DNA damage repair system can cause genome instability and increase cancer risk. The highly ethnic-specific DDR deleterious variation from this study suggests its potential relationship with different disease susceptibility in ethnic human populations.

  • Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response
    Open Access

    Research Article

    Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response

    Shingo Kose, Kenichiro Imai, Ai Watanabe, Akira Nakai, Yutaka Suzuki, Naoko Imamoto

    Shingo Kose ... Naoko Imamoto

    Published 17 May 2022

    Hikeshi mediates proper nucleocytoplasmic distribution of HSP70, which is important for regulating of HSF1 activity and nuclear proteostasis, and adaptive response to heat shock.

  • DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF
    Open Access

    Research Article

    DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF

    Nuria Gutierrez-Prat, Hedwig L Zuberer, Luca Mangano, Zahra Karimaddini, Luise Wolf, Stefka Tyanova, Lisa C Wellinger, Daniel Marbach, Vera Griesser, Piergiorgio Pettazzoni, James R Bischoff, Daniel Rohle, Chiara Palladino, Igor Vivanco

    Nuria Gutierrez-Prat ... Igor Vivanco

    Published 17 May 2022

    Our study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.

  • Expression regulation of genes is linked to their CpG density distributions around transcription start sites
    Open Access

    Research Article

    Expression regulation of genes is linked to their CpG density distributions around transcription start sites

    Hao Tian, Yueying He, Yue Xue, Yi Qin Gao

    Hao Tian ... Yi Qin Gao

    Published 17 May 2022

    In this work, we performed a gene classification which revealed that different gene clusters harbor distinct gene regulatory mechanisms as well as epigenetic mark and expression variations in tumorigenesis.

  • The HDL particle composition determines its antitumor activity in pancreatic cancer
    Open Access

    Research Article

    The HDL particle composition determines its antitumor activity in pancreatic cancer

    Raimund Oberle, Kristina Kührer, Tamina Österreicher, Florian Weber, Stefanie Steinbauer, Florian Udonta, Mark Wroblewski, Isabel Ben-Batalla, Ingrid Hassl, Jakob Körbelin, Matthias Unseld, Matti Jauhiainen, Birgit Plochberger, Clemens Röhrl, Markus Hengstschläger, Sonja Loges, Herbert Stangl

    Raimund Oberle ... Herbert Stangl

    Published 16 May 2022

    The authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.

  • Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy
    Open Access

    Research Article

    Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy

    Manon Garcia, Sylvain Kumanski, Alberto Elías-Villalobos, Chantal Cazevieille, Caroline Soulet, María Moriel-Carretero

    Manon Garcia ... María Moriel-Carretero

    Published 13 May 2022

    We describe a fully new remodeling event of the nuclear envelope surrounding the nucleolus: it partitions into its regular contact with the vacuole and a dramatic internalization of globular cytoplasmic portions within the nucleus.

  • <em>C9ORF72</em>-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons
    Open Access

    Research Article

    C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons

    Paolo M Marchi, Lara Marrone, Laurent Brasseur, Audrey Coens, Christopher P Webster, Luc Bousset, Marco Destro, Emma F Smith, Christa G Walther, Victor Alfred, Raffaele Marroccella, Emily J Graves, Darren Robinson, Allan C Shaw, Lai Mei Wan, Andrew J Grierson, Stephen J Ebbens, Kurt J De Vos, Guillaume M Hautbergue, Laura Ferraiuolo, Ronald Melki, Mimoun Azzouz

    Paolo M Marchi ... Mimoun Azzouz

    Published 13 May 2022

    Extracellularly delivered poly-GAs are internalised into astrocytes via an endocytosis-dependent pathway and then spread to motor neurons, implying non-cell autonomous mechanisms in C9ORF72-ALS/FTD.

  • <em>Plasmodium</em> SAS4: basal body component of male cell which is dispensable for parasite transmission
    Open Access

    Research Article

    Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission

    Mohammad Zeeshan, Declan Brady, Robert Markus, Sue Vaughan, David Ferguson, Anthony A Holder, Rita Tewari

    Mohammad Zeeshan ... Rita Tewari

    Published 12 May 2022

    This work shows that Plasmodium SAS4 is a part of the basal body and outer centriolar MTOC but not essential for male gamete formation.

  • OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection
    Open Access

    Research Article

    OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection

    Elinor Hortle, Vi LT Tran, Kathryn Wright, Angela RM Fontaine, Natalia Pinello, Matthew B O’Rourke, Justin J-L Wong, Philip M Hansbro, Warwick J Britton, Stefan H Oehlers

    Elinor Hortle ... Stefan H Oehlers

    Published 11 May 2022

    Mycobacteria up-regulate host kinase OXSR1 preventing potassium efflux and inflammasome activation. Depletion or inhibition of OXSR1 potentiates inflammasome activation and decreases bacterial burden.

  • Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection
    Open Access

    Research Article

    Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection

    Anoop T Ambikan, Sara Svensson-Akusjärvi, Shuba Krishnan, Maike Sperk, Piotr Nowak, Jan Vesterbacka, Anders Sönnerborg, Rui Benfeitas, Ujjwal Neogi

    Anoop T Ambikan ... Ujjwal Neogi

    Published 10 May 2022

    A system-level up-regulation of OXPHOS and glycolysis could play a role in latent reservoir dynamics and immunosenescence in HIV-1–infected individuals with long-term successful therapy.

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Issue Cover

Current Issue

Volume 5, No. 5
May 2022
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  • ESCRT-I controls lysosomal degradation and MiT-TFE signaling
  • Prime editing for cancer modeling and functional CFTR repair
  • Single blood cell profiles of healthy individuals
  • SMN role in ribosomal DNA damage
  • Laminin as a trophoblast stem cell niche
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