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Newest Articles

  • Lung macrophages utilize unique cathepsin K–dependent phagosomal machinery to degrade intracellular collagen
    Research Article
    Open Access
    Lung macrophages utilize unique cathepsin K–dependent phagosomal machinery to degrade intracellular collagen

    Ivo Fabrik, Orsolya Bilkei-Gorzo, Maria Öberg, Daniela Fabrikova, Johannes Fuchs, Carina Sihlbom, Melker Göransson, Anetta Härtlova

    Ivo Fabrik ... Anetta Härtlova

    Published 25 January 2023

    This study provides a comprehensive map of how peritoneal, lung, and brain tissue environment shapes phagosomal composition, revealing cathepsin K as the main peptidase in the intracellular destruction of collagen, which is mainly active in lung macrophages.

  • Meiotic DNA exchanges in <em>C. elegans</em> are promoted by proximity to the synaptonemal complex
    Research Article
    Open Access
    Meiotic DNA exchanges in C. elegans are promoted by proximity to the synaptonemal complex

    David E Almanzar, Spencer G Gordon, Chloe Bristow, Antonia Hamrick, Lexy von Diezmann, Hanwenheng Liu, Ofer Rog

    David E Almanzar ... Ofer Rog

    Published 25 January 2023

    Exchanges between DNA molecules during meiosis are tightly controlled. This work shows that the synaptonemal complex is instrumental in regulating meiotic exchanges both between the parental chromosomes and between the sister chromatids.

  • The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex
    Research Article
    Open Access
    The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex

    Mashun Onishi, Mitsutaka Kubota, Lan Duan, Yuan Tian, Koji Okamoto

    Mashun Onishi ... Koji Okamoto

    Published 25 January 2023

    The GET pathway promotes anchoring of the Ppg1-Far phosphatase complex to the ER membrane, contributing to initiation of Atg32-mediated mitochondria-specific autophagy in budding yeast.

  • SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β–induced synaptic pathology
    Research Article
    Open Access
    SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β–induced synaptic pathology

    Alfred Kihoon Lee, Nayoung Yi, Husam Khaled, Benjamin Feller, Hideto Takahashi

    Alfred Kihoon Lee ... Hideto Takahashi

    Published 25 January 2023

    The protein sorting receptor SorCS1 shields the synapse organizer β-neurexins from amyloid-β oligomers (AβOs) to alleviate AβO-induced synaptic pathology.

  • Multiple phosphorylation of the Cdc48/p97 cofactor protein Shp1/p47 occurs upon cell stress in budding yeast
    Research Article
    Open Access
    Multiple phosphorylation of the Cdc48/p97 cofactor protein Shp1/p47 occurs upon cell stress in budding yeast

    Alexander Agrotis, Frederic Lamoliatte, Thomas D Williams, Ailsa Black, Rhuari Horberry, Adrien Rousseau

    Alexander Agrotis ... Adrien Rousseau

    Published 24 January 2023

    This study shows that phosphorylation of the yeast p97/Cdc48 adaptor protein Shp1 is enhanced upon multiple stresses, a process regulated by both Mpk1 kinase and PP1 phosphatase.

  • Reviewer Index
    Open Access
    2022 Reviewer Index

    Eric Sawey

    Eric Sawey

    Published 23 January 2023

    The LSA Editors thank these scientists for sharing their time and expertise while reviewing manuscripts in 2022. We sincerely appreciate their support.

  • S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation
    Research Article
    Open Access
    S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation

    Tao Yu, Xi Li, Qianqian Luo, Huajing Liu, Jing Jin, Shengjie Li, Jun He

    Tao Yu ... Jun He

    Published 23 January 2023

    This study shows that S417 of STIM1 plays an essential role in STIM1 C-terminus–Orai1 interaction and CRAC channel activation. It also presents new findings about 2-APB’s action on CRAC channel, which provides a tool for better understanding of SOCE activation.

  • Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2
    Research Article
    Open Access
    Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2

    Zachary J Frangos, Katie A Wilson, Heather M Aitken, Ryan Cantwell Chater, Robert J Vandenberg, Megan L O’Mara

    Zachary J Frangos ... Megan L O’Mara

    Published 23 January 2023

    Cholesterol binds to the GlyT2 SLC6 transporter, enhancing the effect of bioactive lipid analgesics, providing new therapeutic avenues to treat neuropathic pain and target SLC6 transporters.

  • Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing
    Research Article
    Open Access
    Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing

    Annika Breidenstein, Josy ter Beek, Ronnie P-A Berntsson

    Annika Breidenstein ... Ronnie P-A Berntsson

    Published 20 January 2023

    Characterization of relaxase TraI from pKM101 highlights large conformational changes upon DNA binding, and unlike previous reports shows similar behavior as its homologs from the R388 and F plasmids.

  • An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinoma
    Research Article
    Open Access
    An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinoma

    Zizhen Si, GuanJun Yang, Xidi Wang, Zhaoying Yu, Qian Pang, Shuangshuang Zhang, Liyin Qian, Yuer Ruan, Jing Huang, Liu Yu

    Zizhen Si ... Liu Yu

    Published 20 January 2023

    METH use is associated with a higher incidence of hepatocellular carcinoma (HCC) in METH abusers and rehabilitees. METH exposure promotes HCC progression by ROS-mediated activation of the Ras/MEK/ERK signaling pathway. Clearance of ROS by NAC abolishes METH-induced HCC progression.

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Issue Cover

Current Issue

Volume 6, No. 1
January 2023
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  • Arctic algal genomic convergence
  • NDR1/2 enhance autophagy via ATG9 trafficking
  • Concordance of MERFISH with single-cell RNA-Seq
  • PIEZO1 and muscle stem cell division
  • Drosophila pVALIUM10 TRiP RNAi lines found their off-targets
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