Newest Articles
- ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway
The GET pathway is required to target non-imported mitochondrial carrier proteins to the endoplasmic reticulum, which prevents their deposition into Hsp42-dependent protein foci.
- Reduced RNA turnover as a driver of cellular senescence
RNAs originating from transcription upstream and downstream of genes accumulate in the cytoplasm of a subset of senescent cells, suggesting an RNA alternative to cytoplasmic DNA in the triggering of senescence.
- MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility
In situ proteomics of male infertility.
- Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1
Main mitotic kinases as PLK1 are activated at the S/G2 transition. A change in Cyclin A2 localisation at the S/G2 transition enables activation of PLK1.
- Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories
Using integrated genome-wide and phenotypic methods this study investigates four different mutant RUNX1 oncoproteins and reveals how they differentially contribute to aberrant haematopoiesis.
- Tissue-selective alternate promoters guide NLRP6 expression
The NLRP6 innate immune sensor is regulated by tissue-selective alternate promoters that facilitate translational gene silencing outside of the intestinal epithelium in both humans and mice.
- The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells
Using ChIP-seq and functional genomic analyses, the study shows that the Paf1 complex occupies transcriptional enhancers and positively regulates their activity.
- Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formation
N-terminal Aub arginines are dispensable for primary piRNA biogenesis but essential for amplification; their symmetric dimethylation is required for germline inheritance but not for piRNA amplification.
- The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells
The RNA-binding protein SRSF6 recognizes a purine-rich consensus motif consisting of GAA triplets, and its downregulation in human pancreatic β-cells affects alternative splicing in a position-dependent manner.