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Newest Articles

  • The Ragulator complex and lysosomal calcium release are crucial for cell migration
    Research Article
    Open Access
    The Ragulator complex and lysosomal calcium release are crucial for cell migration

    Tatsunori Jo, Kohei Tsujimoto, Takeshi Nakatani, Daiki Nagira, Yutaka Muto, Takehiro Hirayama, Hachiro Konaka, Masato Okada, Hyota Takamatsu, Atsushi Kumanogoh

    Tatsunori Jo ... Atsushi Kumanogoh

    Published 10 June 2025

    Lysosomal calcium efflux via TRPML1 drives leukocyte migration by enhancing Lamtor1–MPRIP interaction, and ouabain improves pathogenic inflammation by disrupting Lamtor1’s lysosomal localization.

  • RalGAP complexes control secretion and primary cilia in pancreatic disease
    Research Article
    Open Access
    RalGAP complexes control secretion and primary cilia in pancreatic disease

    Lisa H Apken, Hannah Barz, Stephanie Beel, Esther Michalke, René Rasche, Archana Verma, Andrea Ricker, Harald Nüsse, Jürgen Klingauf, Kornelius Kerl, Eva Wardelmann, Daniel Kümmel, Konrad Steinestel, Zoltán Pethő, Michael Meisterernst, Andrea Oeckinghaus

    Lisa H Apken ... Andrea Oeckinghaus

    Published 9 June 2025

    Loss of RalGAP impacts secretion, cell polarity, and primary cilium formation, results in pancreatitis and neoplasia development in the pancreas, and promotes mutant KRas-driven tumorigenesis.

  • Structural studies on ribosomes of differentially macrolide-resistant <em>Staphylococcus aureus</em> strains
    Research Article
    Open Access
    Structural studies on ribosomes of differentially macrolide-resistant Staphylococcus aureus strains

    André Rivalta, Aliza Fedorenko, Alexandre Le Scornet, Sophie Thompson, Yehuda Halfon, Elinor Breiner Goldstein, Sude Çavdaroglu, Tal Melenitzky, Disha-Gajanan Hiregange, Ella Zimmerman, Anat Bashan, Mee-Ngan Frances Yap, Ada Yonath

    André Rivalta ... Ada Yonath

    Published 9 June 2025

    Macrolide resistance in Staphylococcus aureus is mediated by Erm-family methyltransferases, altering ribosomal drug binding. Using cryo-EM, we analyze solithromycin-bound ribosomes from resistant strains, revealing interactions that may enhance antibiotic efficacy.

  • C-terminal binding protein 2 interacts with JUNB to control macrophage inflammation
    Research Article
    Open Access
    C-terminal binding protein 2 interacts with JUNB to control macrophage inflammation

    Benjamin A Strickland, Antonia Babl, Lena Wolff, Priya Singh, Marika E Friano, Franziska Greulich, N Henriette Uhlenhaut

    Benjamin A Strickland ... N Henriette Uhlenhaut

    Published 9 June 2025

    This study identifies CTBP2 as an oligomerization-dependent bridge between pro-inflammatory transcription factors and co-repressors that balances the expression of inflammatory genes.

  • Cross-comparison of strains used for mitochondrial imaging in <em>Caenorhabditis elegans</em> during aging
    Resource
    Open Access
    Cross-comparison of strains used for mitochondrial imaging in Caenorhabditis elegans during aging

    Juri Kim, Naibedya Dutta, Matthew Vega, Andrew Bong, Maxim Averbukh, Rebecca Aviles Barahona, Athena Alcala, Jacob T Holmes, Gilberto Garcia, Ryo Higuchi-Sanabria

    Juri Kim ... Ryo Higuchi-Sanabria

    Published 3 June 2025

    This study evaluates mitochondrial imaging in C. elegans during aging, comparing various transgenic constructs for tissue-specific mitochondrial visualization. The findings highlight technical considerations, imaging method standardization, and the utility of C. elegans as a robust model for studying mitochondrial dynamics.

  • Condensate-forming eIF4ET ensures adequate levels of meiotic proteins to support oocyte storage
    Research Article
    Open Access
    Condensate-forming eIF4ET ensures adequate levels of meiotic proteins to support oocyte storage

    Priyankaa Bhatia, Judith Tafur, Ruchi Amin, Nicole E Familiari, Kan Yaguchi, Vanna M Tran, Alec Bond, Orhan Bukulmez, Jeffrey B Woodruff

    Priyankaa Bhatia ... Jeffrey B Woodruff

    Published 29 May 2025

    Bhatia et al use female nematodes to reveal how the conserved eIF4E-transporter protein (eIF4ET) plays an unexpected role in promoting translation of cytoskeletal proteins to support days-long storage of arrested oocytes.

  • Tbx1 plays a critical role in focal adhesion dynamics through paxillin regulation
    Research Article
    Open Access
    Tbx1 plays a critical role in focal adhesion dynamics through paxillin regulation

    Olimpia Iacolare, Rosa Ferrentino, Alessandra Altomonte, Christopher E Turner, Antonio Baldini, Daniela Alfano

    Olimpia Iacolare ... Daniela Alfano

    Published 29 May 2025

    Tbx1 is essential for cell adhesion by regulating focal adhesion dynamics, primarily through influencing the disassembly process. Tbx1 modulates cell spreading via the paxillin signalling pathway and integrin trafficking control.

  • Deep learning models link local cellular features with whole-animal growth dynamics in zebrafish
    Research Article
    Open Access
    Deep learning models link local cellular features with whole-animal growth dynamics in zebrafish

    Shang-Ru Yang, Megan Liaw, An-Chi Wei, Chen-Hui Chen

    Shang-Ru Yang ... Chen-Hui Chen

    Published 21 May 2025

    The study introduces a deep learning-assisted approach for uncovering the intricate, real-time cross-length scale interactions between individual cells and the entire organism in a vertebrate model.

  • Inhibition of xanthine oxidoreductase with febuxostat, but not allopurinol, prevents inflammasome assembly and IL-1β release
    Research Article
    Open Access
    Inhibition of xanthine oxidoreductase with febuxostat, but not allopurinol, prevents inflammasome assembly and IL-1β release

    Lauar de Brito Monteiro, Anne-Sophie Archambault, Lucas F Starchuk, Armando Alcazar, Ju Hee Oh, Joshua A Dubland, Bojana Rakić, Annette E Patterson, C Bruce Verchere, Ramon I Klein Geltink

    Lauar de Brito Monteiro ... Ramon I Klein Geltink

    Published 21 May 2025

    This study focuses on the underappreciated distinct effects of two clinically used xanthine oxidoreductase inhibitors: allopurinol and febuxostat. Besides reducing uric acid levels in gout treatment, febuxostat, but not allopurinol, prevents NLRP3 inflammasome assembly and blocks IL-1β production by macrophages.

  • A fluorescent sensor for real-time monitoring of DPP8/9 reveals crucial roles in immunity and cancer
    Methods
    Open Access
    A fluorescent sensor for real-time monitoring of DPP8/9 reveals crucial roles in immunity and cancer

    Konstantin Weiss, Yelizaveta Agarkova, Alexandra Zwosta, Sarah Hoevel, Ann-Kathrin Himmelreich, Magdalena Shumanska, Julia Etich, Gereon Poschmann, Bent Brachvogel, Ivan Bogeski, Dirk Mielenz, Jan Riemer

    Konstantin Weiss ... Jan Riemer

    Published 12 May 2025

    Weiss et al developed a genetically encoded biosensor for real-time monitoring of DPP8/9 activity, an important protease, and revealed roles of DPP8/9 in B-cell maturation and melanoma proliferation.

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Issue Cover

Current Issue

Volume 8, No. 6
June 2025
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  • Message from the new Executive Editor
  • Effective cell cycle synchronization
  • DiPAK senses DPP8/9 activity
  • Senescent macrophages and adipose tissue fibrosis
  • Ocular blood flow reduction promote RGC loss
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