Newest Articles
The Ragulator complex and lysosomal calcium release are crucial for cell migrationLysosomal calcium efflux via TRPML1 drives leukocyte migration by enhancing Lamtor1–MPRIP interaction, and ouabain improves pathogenic inflammation by disrupting Lamtor1’s lysosomal localization.
RalGAP complexes control secretion and primary cilia in pancreatic diseaseLoss of RalGAP impacts secretion, cell polarity, and primary cilium formation, results in pancreatitis and neoplasia development in the pancreas, and promotes mutant KRas-driven tumorigenesis.
Structural studies on ribosomes of differentially macrolide-resistant Staphylococcus aureus strainsMacrolide resistance in Staphylococcus aureus is mediated by Erm-family methyltransferases, altering ribosomal drug binding. Using cryo-EM, we analyze solithromycin-bound ribosomes from resistant strains, revealing interactions that may enhance antibiotic efficacy.
C-terminal binding protein 2 interacts with JUNB to control macrophage inflammationThis study identifies CTBP2 as an oligomerization-dependent bridge between pro-inflammatory transcription factors and co-repressors that balances the expression of inflammatory genes.
Cross-comparison of strains used for mitochondrial imaging in Caenorhabditis elegans during agingThis study evaluates mitochondrial imaging in C. elegans during aging, comparing various transgenic constructs for tissue-specific mitochondrial visualization. The findings highlight technical considerations, imaging method standardization, and the utility of C. elegans as a robust model for studying mitochondrial dynamics.
Condensate-forming eIF4ET ensures adequate levels of meiotic proteins to support oocyte storageBhatia et al use female nematodes to reveal how the conserved eIF4E-transporter protein (eIF4ET) plays an unexpected role in promoting translation of cytoskeletal proteins to support days-long storage of arrested oocytes.
Tbx1 plays a critical role in focal adhesion dynamics through paxillin regulationTbx1 is essential for cell adhesion by regulating focal adhesion dynamics, primarily through influencing the disassembly process. Tbx1 modulates cell spreading via the paxillin signalling pathway and integrin trafficking control.
Deep learning models link local cellular features with whole-animal growth dynamics in zebrafishThe study introduces a deep learning-assisted approach for uncovering the intricate, real-time cross-length scale interactions between individual cells and the entire organism in a vertebrate model.
Inhibition of xanthine oxidoreductase with febuxostat, but not allopurinol, prevents inflammasome assembly and IL-1β releaseThis study focuses on the underappreciated distinct effects of two clinically used xanthine oxidoreductase inhibitors: allopurinol and febuxostat. Besides reducing uric acid levels in gout treatment, febuxostat, but not allopurinol, prevents NLRP3 inflammasome assembly and blocks IL-1β production by macrophages.
A fluorescent sensor for real-time monitoring of DPP8/9 reveals crucial roles in immunity and cancerWeiss et al developed a genetically encoded biosensor for real-time monitoring of DPP8/9 activity, an important protease, and revealed roles of DPP8/9 in B-cell maturation and melanoma proliferation.
