Newest Articles
- Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain
Comparative analysis reveals adaptive evolution of bat IFITMs and a naturally polymorphic site within the conserved CD225 domain that affects S-palmitoylation and antiviral function of bat IFITM3.
- Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis
Immune dysfunction determines morbidity and mortality in liver cirrhosis. Distinct AXL-expressing circulating monocytes, which regulate antimicrobial responses, expand with progression of the disease.
- MERLIN: a novel BRET-based proximity biosensor for studying mitochondria–ER contact sites
MERLIN is a novel biosensor that generates a BRET signal with a signal-to-noise ratio that is sufficient to enable sensing the proximity between the mitochondria and the ER without forcing interaction or establishing artificial connections at the MERCs.
- Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells
Loss of Runx/Cbfβ complexes during DC development leads to a loss of gut CD103+CD11b+ cDC2s, which was accompanied with impaired differentiation of both Rorγt+ Th17 cells and type 3 Rorγt+ Treg cells.
- A comprehensive resource for retrieving, visualizing, and integrating functional genomics data
This study presents qcGenomics, a user-friendly online resource for ultrafast retrieval, visualization, and comparative analysis of tens of thousands of genomics datasets to gain new functional insight from global or focused multi-dimensional data integration.
- TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life
This study demonstrates that the tetraspanins Tspan5 and Tspan15 which directly associate with the metalloprotease ADAM10 have an opposite impact on its endocytosis and half-life.
- Phenotypic proteomic profiling identifies a landscape of targets for circadian clock–modulating compounds
This study provides comprehensive insights into the mechanism of action and cellular effects of circadian period–modulating compounds, which is critical for clearly defining molecular targets to modulate daily rhythms for therapeutic benefit.
- Evaluation of colorectal cancer subtypes and cell lines using deep learning
A deep learning approach refines the state-of-the-art subtypes of colorectal cancer and evaluates the fidelity of cell lines that model cancer.
- CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation
IKKα is an NSCLC suppressor and its loss in mouse AT-II lung epithelial cells or in human NSCLC lines increased urethane-induced adenoma growth and xenograft burdens, respectively. IKKα loss can up-regulate HIF-1α, enhancing tumor growth under hypoxia.
- ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival
ADAP1, a GTPase-activating protein (GAP) for the small GTPase ARF6, is a strong predictor of poor survival in early-stage squamous cell carcinoma patients and a critical mediator of TGF-β-induced invasive cell migration by facilitating basement membrane breakdown.