Newest Articles
Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progressionCrosstalk between bone metastatic cancer cells and sensory nerves has not yet been fully elucidated. We demonstrate the involvement of CGRP-expressing sensory nerves in bone metastatic progression and identify the CGRP/CRLR axis as a potential therapeutic target for bone metastasis.
Novel imaging tools to study mitochondrial morphology in Caenorhabditis elegansThis study presents novel genetic tools for live imaging of mitochondrial morphology in the nematode Caenorhabditis elegans, offering insights into mitochondrial dynamics and providing a thorough comparison with existing methods.
Structural roles of Ump1 and β-subunit propeptides in proteasome biogenesisA 2.1 Å cryo-EM structure of a late proteasome precursor reveals roles of the assembly chaperone Ump1 and β-subunit propeptides in proteasome biogenesis.
Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1bThe study represents the first functional dissection of the two human cofactors present in the RNA decapping complex, and, significantly, it evaluates their role in the transcript buffering system.
Mast cell extracellular trap formation underlies vascular and neural injury and hyperalgesia in sickle cell diseaseMast cell extracellular traps catalyzed by peptidylarginine deiminase 4 contribute to vascular stasis and nerve injury, which may contribute to acute and chronic pain in sickle cell disease.
Regulation of proteostasis by sleep through autophagy in Drosophila models of Alzheimer’s diseaseSleep modulation alters Tau-induced neurodegeneration in Drosophila models of tauopathy.
Cell-Int: a cell–cell interaction assay to identify native membrane protein interactionsA cell interaction assay to study membrane protein interactions in quasi-physiological settings, with multiple applications, from deciphering interaction networks to assessing therapeutic molecules.
A novel role for CSA in the regulation of nuclear envelope integrity: uncovering a non-canonical functionIdentification of a new function for CSA protein in the regulation of the nuclear envelope, preventing nuclear ruptures and activation of inflammation pathways.
Differential modulation of polycomb-associated histone marks by cBAF, pBAF, and gBAF complexesThis study shows that the canonical BAF (cBAF) complex uniquely opposes polycomb-associated repressive marks at the Nkx2-9 gene in mouse embryonic stem cells, leading to transcriptional activation, a function not shared by gBAF or pBAF complexes.
- Retraction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3
Chitinase 1 (CHIT1) plays a role in the pathogenesis of pulmonary fibrosis by modulating canonical and noncanonical TGF-β signaling via interaction with TGFBRAP1 and FOXO3. These findings highlight the CHIT1/SMAD7 axis as a potential biomarker and therapeutic target of pulmonary fibrosis.
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