Newest Articles
A new metabolic model of Drosophila melanogaster and the integrative analysis of Parkinson’s diseaseThe reconstruction of a comprehensive and literature-curated Drosophila metabolic model, iDrosophila1, provided a powerful platform for studying metabolism with systems medicine perspective.
Estimation of crossbridge-state during cardiomyocyte beating using second harmonic generationThis article describes a new method to evaluate the actomyosin activity in living cardiomyocytes during beating based on nonlinear scattering microscopy, which will be useful for elucidating cardiomyopathy mechanisms, efficacy of an intervention, and others.
Modeling fibrotic alveolar transitional cells with pluripotent stem cell-derived alveolar organoidsIn vitro modeling of transitional alveolar epithelial cells in idiopathic pulmonary fibrosis by the use of a fibrosis cocktail and alveolar organoids from induced pluripotent stem cells.
UHRF1 is essential for proper cytoplasmic architecture and function of mouse oocytes and derived embryosThis study shows that the UHRF1 protein, an epigenetic factor, regulates cytoplasmic proteins in oocytes independently of gene expression and ensures normal preimplantation development.
Inter and transgenerational impact of H3K4 methylation in neuronal homeostasisThe study highlights the importance of maintaining appropriate H3K4me3 levels to prevent negative impacts on nerve system homeostasis across generations.
MAP4K3 inhibits Sirtuin-1 to repress the LKB1–AMPK pathway to promote amino acid-dependent activation of the mTORC1 complexOur results reveal the existence of a novel signaling pathway linking amino acid satiety with MAP4K3-dependent suppression of SIRT1 to inactivate the repressive LKB1–AMPK pathway and thereby potently activate the mTORC1 complex to dictate the metabolic disposition of the cell.
The CHARGE syndrome-associated protein FAM172A controls AGO2 nuclear importAGO2 has long been known to shuttle between the cytosol and the nucleus of mammalian cells and this study helps to understand how this occurs.
Origin and segregation of the human germlineHuman primordial germ cells originate in peri-gastrulation embryos from the posterior epiblast precursors with an obligatory role for TFAP2A, which is redundant for contribution to the amnion.
WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to ciliumOur research reveals that the deletion of WDR-31, RP-2, and ELMD-1 is leading to ciliary accumulation of IFT Complex B components and KIF17 kinesin. In conclusion, WDR31, ELMOD, and RP2 are working in regulating IFT via the BBSome.
Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cellsThe expression of the virus-activating protease TMPRSS2 in airway cells is enhanced by bacterial components. This may contribute to virus activation and replication in co-infections of IAV and bacteria.
