Newest Articles
Research Article
INPP5K and Atlastin-1 maintain the nonuniform distribution of ER–plasma membrane contacts in neuronsCIL-1 and ATLN-1 maintain the balance between ER tubules and sheets and prevent invasion of cortical ER sheets into the axon, contributing to the non-uniform distribution of neuronal ER-PM contacts.
Research Article
Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infectionCytotoxic killer CD8+ T cells (CTLs) are central effectors that eliminate virus infected cells. In HIV infection, HIV-specific CTLs become functionally impaired. Herein we investigated the link between metabolism and CD8+ T-cell functional impairment, known as exhaustion.
Research Article
Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in miceOptogenetic activation of FGFR2 allowed temporally precise induction of signaling and behavioural changes, but counter-regulation at multiple levels prevented a sustained response in keratinocytes.
Research Article
Choroid plexus APP regulates adult brain proliferation and animal behaviorAdult mouse choroid plexus shows elevated APP expression. sAPPα secreted into the CSF modulates neurogenic niche proliferation, whereas choroid plexus expression of fAD APP mutants leads to reduced niche proliferation, deficits in hippocampus synaptic plasticity, and learning defects.
Research Article
An extended DNA-free intranuclear compartment organizes centrosome microtubules in malaria parasitesMalaria arises during the proliferation of Plasmodium spp. in human blood, whereas the underlying atypical cell division mechanisms remain poorly understood. This study uses advanced imaging to dissect dynamics and organization of the centrosome, a key division regulator.
Research Article
The Th1 cell regulatory circuitry is largely conserved between human and mouseComparison of the binding sites of the Th1 lineage-specifying transcription factor T-bet between human and mouse reveals differences in binding sites but that the most of the target genes are shared.
Research Article
Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signalingThis study analyses the function of the protein tyrosine phosphatase 1B identifying its binding partners and dephosphorylation targets for modulating B cell antigen receptor signaling.
Research Article
Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19COVID-19 induces high levels of autoimmune anti-DNA and anti-phosphatidylserine antibodies that are detected in some patients upon hospital admission and predict later development of severe disease.
Research Article
Ccq1–Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeresThis study unveils a role of Ccq1–Raf2 interaction in CLRC recruitment to establish heterochromatin at telomeres, providing a positive feedback mechanism between shelterin and CLRC for subtelomeric heterochromatin assembly.
Research Article
Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage responseThis work studies known and new ADPRHL2 mutations with different disease mechanisms overall indicating that loss of nuclear ARH3 alone is pathogenic via dysregulated nuclear ADP ribosylation.
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