Newest Articles
Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatusThe mutation P88L in subunit HapE of the CCAAT transcription factor causes resistance of Aspergillus fumigatus to azole drugs due to altered binding, bending, and transcription of target promoters.
STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancersThis work highlights the degradation of STAG1 and inhibition of its interaction with cohesin as promising therapeutic strategies for exploiting synthetic lethality to treat STAG2-mutated tumors and lays the groundwork for the discovery of STAG1-directed small molecules.
Lipid-associated PML structures assemble nuclear lipid droplets containing CCTα and Lipin1PML proteins assemble into noncanonical lipid-associated PML structures (LAPS) on nuclear lipid droplets, which recruit CCTα and Lipin1 for the synthesis of phosphatidylcholine and triacylglycerol.
Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancerEngaging the immunoproteasome helps maintain proteostasis during TNBC development, but ultimately leads to increased immune visibility and favorable prognosis. Assessing i-proteasome expression could augment the prognostic and/or predictive value of TILs assessment in diagnostic practice.
Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesisAlthough hair bulge stem cells are not the cancer cells-of-origin, they contribute to two-stage DMBA/TPA skin carcinogenesis in an α3β1-dependent manner.
Regulation of axonal morphogenesis by the mitochondrial protein Efhd1Ablation of the mitochondrial protein Efhd1 in mice interferes with normal development of sensory axons and results in mitochondrial dysfunction associated with activation of cellular stress pathways.
MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signalingMAPK mutations favor HNSCC survival, revealing the broad clinical utility of MAPK pathway mutations in prognosis and potentially in precision immunotherapy.
Pancreatic cancer triggers diabetes through TGF-β–mediated selective depletion of islet β-cellsPancreatic ductal adenocarcinoma formation culminates in hyperactivation of transforming growth factor β signaling, which in turn induces selective depletion of β-cell mass and thereby leading to new-onset diabetes.
Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolismInhibition of the Alzheimer associated γ-secretase impairs the regulation of cellular lipid droplet homeostasis.
