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Newest Articles

  • Open Access
    Correction: MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility

    Shibojyoti Lahiri, Wasim Aftab, Lena Walenta, Leena Strauss, Matti Poutanen, Artur Mayerhofer, Axel Imhof

    Shibojyoti Lahiri ... Axel Imhof

    Published 21 January 2021

    Correction

  • ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway
    Open Access
    ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway

    Tianyao Xiao, Viplendra PS Shakya, Adam L Hughes

    Tianyao Xiao ... Adam L Hughes

    Published 21 January 2021

    The GET pathway is required to target non-imported mitochondrial carrier proteins to the endoplasmic reticulum, which prevents their deposition into Hsp42-dependent protein foci.

  • Reduced RNA turnover as a driver of cellular senescence
    Open Access
    Reduced RNA turnover as a driver of cellular senescence

    Nowsheen Mullani, Yevheniia Porozhan, Adèle Mangelinck, Christophe Rachez, Mickael Costallat, Eric Batsché, Michele Goodhardt, Giovanni Cenci, Carl Mann, Christian Muchardt

    Nowsheen Mullani ... Christian Muchardt

    Published 14 January 2021

    RNAs originating from transcription upstream and downstream of genes accumulate in the cytoplasm of a subset of senescent cells, suggesting an RNA alternative to cytoplasmic DNA in the triggering of senescence.

  • MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility
    Open Access
    MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility

    Shibojyoti Lahiri, Wasim Aftab, Lena Walenta, Leena Strauss, Matti Poutanen, Artur Mayerhofer, Axel Imhof

    Shibojyoti Lahiri ... Axel Imhof

    Published 6 January 2021

    In situ proteomics of male infertility.

  • Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1
    Open Access
    Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1

    Helena Silva Cascales, Kamila Burdova, Anna Middleton, Vladislav Kuzin, Erik Müllers, Henriette Stoy, Laura Baranello, Libor Macurek, Arne Lindqvist

    Helena Silva Cascales ... Arne Lindqvist

    Published 5 January 2021

    Main mitotic kinases as PLK1 are activated at the S/G2 transition. A change in Cyclin A2 localisation at the S/G2 transition enables activation of PLK1.

  • Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories
    Open Access
    Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories

    Sophie G Kellaway, Peter Keane, Benjamin Edginton-White, Kakkad Regha, Ella Kennett, Constanze Bonifer

    Sophie G Kellaway ... Constanze Bonifer

    Published 4 January 2021

    Using integrated genome-wide and phenotypic methods this study investigates four different mutant RUNX1 oncoproteins and reveals how they differentially contribute to aberrant haematopoiesis.

  • Tissue-selective alternate promoters guide NLRP6 expression
    Open Access
    Tissue-selective alternate promoters guide NLRP6 expression

    Nathan A Bracey, Jaye M Platnich, Arthur Lau, Hyunjae Chung, M Eric Hyndman, Justin A MacDonald, Justin Chun, Paul L Beck, Stephen E Girardin, Paul MK Gordon, Daniel A Muruve

    Nathan A Bracey ... Daniel A Muruve

    Published 29 December 2020

    The NLRP6 innate immune sensor is regulated by tissue-selective alternate promoters that facilitate translational gene silencing outside of the intestinal epithelium in both humans and mice.

  • The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells
    Open Access
    The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells

    Li Ding, Maciej Paszkowski-Rogacz, Jovan Mircetic, Debojyoti Chakraborty, Frank Buchholz

    Li Ding ... Frank Buchholz

    Published 29 December 2020

    Using ChIP-seq and functional genomic analyses, the study shows that the Paf1 complex occupies transcriptional enhancers and positively regulates their activity.

  • Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formation
    Open Access
    Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formation

    Nicholas Vrettos, Manolis Maragkakis, Panagiotis Alexiou, Paraskevi Sgourdou, Fadia Ibrahim, Daniel Palmieri, Yohei Kirino, Zissimos Mourelatos

    Nicholas Vrettos ... Zissimos Mourelatos

    Published 29 December 2020

    N-terminal Aub arginines are dispensable for primary piRNA biogenesis but essential for amplification; their symmetric dimethylation is required for germline inheritance but not for piRNA amplification.

  • The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells
    Open Access
    The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells

    Maria Inês Alvelos, Mirko Brüggemann, FX Reymond Sutandy, Jonàs Juan-Mateu, Maikel Luis Colli, Anke Busch, Miguel Lopes, Ângela Castela, Annemieke Aartsma-Rus, Julian König, Kathi Zarnack, Décio L Eizirik

    Maria Inês Alvelos ... Décio L Eizirik

    Published 29 December 2020

    The RNA-binding protein SRSF6 recognizes a purine-rich consensus motif consisting of GAA triplets, and its downregulation in human pancreatic β-cells affects alternative splicing in a position-dependent manner.

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Current Issue

Volume 3, No. 12
December 2020
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