Cell Biology 2024
Last updated
We are pleased to present this special collection of articles recently published in LSA highlighting some of the latest advances in cell biology. Articles featured in the collection were published within the past 12 months and include original findings on mitochondrial double-stranded RNA dynamics, nuclear envelope integrity, and the integrated stress response. We hope you enjoy reading this collection, and we invite you to follow LSA on Twitter (@LSAjournal). Learn more about submitting your research.
Image © 2024 Gong et al.
The FuVis2 reporter system, designed to visualize cell nuclei harboring sister chromatid fusion, equipped with cGAS/STING reporters, offers critical insights that micronuclei are primarily captured by cGAS during mitosis but do not lead to STING activation.
Identification of a new function for CSA protein in the regulation of the nuclear envelope, preventing nuclear ruptures and activation of inflammation pathways.
Mitochondrial double-stranded RNA is a new signaling molecule that, likely under stress conditions, is exported to induce a type 1 interferon response, thus mimicking a viral response. This export pathway is detected in a subset of lung cancer cell lines.
The accumulation of mitochondrial double-stranded RNA (mt-dsRNA) in cancer cells depends on cell proliferation status. Mt-dsRNA is more abundant in patient lung adenocarcinoma compared with healthy tissue.
This study reports the first nanobodies against the mitochondrial fission protein Drp1 for application in proteomics, high-resolution microscopy and live cell imaging.
We characterized the genetic consequences of deleting IGHMBP2—a disease-relevant perturbation—in human cells. IGHMBP2-dependent gene expression changes included up-regulation of ATF4, a key ISR factor.
Transmembrane E3 ligases RNF43 and ZNRF3 selectively target specific Frizzled receptors to suppress WNT signalling, offering an explanation for the cancer tissue-specific distribution of RNF43 and ZNRF3 mutations.
Tubulin dimers concentrate within an ER spindle envelope because cytoplasmic organelles outside the envelope occupy significant volume.
A genetic screen in Drosophila photoreceptors uncovers multiple regulators of lipid transfer function and endoplasmic reticulum–plasma membrane contact sites.
C9orf72 mutations cause multiple mitochondrial disruptions, but only genetically boosting antioxidant expression rescued motor deficits in vivo, supporting a pathogenic connection. Genetic or pharmacological activation of the Keap1/Nrf2 pathway ameliorated pathological phenotypes in Drosophila models and patient-derived iNeurons.
