Cell Biology 2022
Last updated
We are pleased to present this special collection of articles recently published in LSA highlighting some of the latest advances in cell biology. Articles featured in the collection were published within the past 12 months and include original findings on DNA repair, ER stress and mycobacterial infection. We hope you enjoy reading this collection, and we invite you to follow LSA on Twitter (@LSAjournal). Learn more about submitting your research at https://www.life-science-alliance.org.
Image © 2022 Zheng et al.
The tRNA ligase RtcB is tyrosine phosphorylated upon ER stress which in turn leads to modulation of XBP1 mRNA splicing and IRE1 signaling outputs.
The HIV type 1 dampens host cell sumoylation in vitro and reduces the expression of UBA2 protein, a subunit of the SUMO E1–activating enzyme. In vivo, infection in patients is associated with diminished global leukocyte sumoylation activity.
Procollagen Iα1 with two tags reveals the different fates of processed propeptides, the rate-limiting step in collagen secretion, and a link between defects in intracellular processing and diseases.
The research uncovers a non-canonical role of ERK in TGF-beta-induced EMT, revealing ERK-mediated phosphorylation of Smurf1 is required for its sufficient binding to RhoA and the subsequent RhoA turnover.
Mycobacteria up-regulate host kinase OXSR1 preventing potassium efflux and inflammasome activation. Depletion or inhibition of OXSR1 potentiates inflammasome activation and decreases bacterial burden.
The role of novel Rab40c/CRL5 ubiquitylation complex in regulating PP6 activity and cell migration.
In this work, it is revealed that the broad viral inhibitor IFITM3 is a previously unrecognized modulator of the functionalities of the cellular ER–Golgi secretory pathway.
Nanobody toolkit enables the quantitative analysis of endosome-to-TGN transport of the mannose-6-phosphate receptor in cells depleted of retrograde transport machineries.
Cell division completes when the two daughter cells move their oldest centrosome towards the cytokinetic bridge, which is then cleaved during abscission. The GTPase, Rab11, and the centrosome protein, Pericentrin, work together to coordinate this movement.
