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Cancer Biology 2021

Last updated

7 April 2021 6:41

We are excited to share with you recent and exciting discoveries across the spectrum of cancer research that were published in Life Science Alliance (LSA) within the last year. This LSA collection covers works that advance our understanding of genetic, immune, and metabolic influences on tumor development and progression, and reflects LSA’s scope and interest in cancer research – from molecular and cellular events to immune evasion of cancer cells and therapeutic responsiveness of tumors.

Connect with LSA on Twitter or contact our editorial office with any feedback or questions.


Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories
Sophie G Kellaway, Peter Keane, Benjamin Edginton-White, Kakkad Regha, Ella Kennett, Constanze Bonifer

Using integrated genome-wide and phenotypic methods this study investigates four different mutant RUNX1 oncoproteins and reveals how they differentially contribute to aberrant haematopoiesis.

 

Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer
Alaknanda Adwal, Priyakshi Kalita-de Croft, Reshma Shakya, Malcolm Lim, Emarene Kalaw, Lucinda D Taege, Amy E McCart Reed, Sunil R Lakhani, David F Callen, Jodi M Saunus

Engaging the immunoproteasome helps maintain proteostasis during TNBC development, but ultimately leads to increased immune visibility and favorable prognosis. Assessing i-proteasome expression could augment the prognostic and/or predictive value of TILs assessment in diagnostic practice.
 

MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling
Hoi-Lam Ngan, Yuchen Liu, Andrew Yuon Fong, Peony Hiu Yan Poon, Chun Kit Yeung, Sharon Suet Man Chan, Alexandria Lau, Wenying Piao, Hui Li, Jessie Sze Wing Tse, Kwok-Wai Lo, Sze Man Chan, Yu-Xiong Su, Jason Ying Kuen Chan, Chin Wang Lau, Gordon B Mills, Jennifer Rubin Grandis, Vivian Wai Yan Lui

MAPK mutations favor HNSCC survival, revealing the broad clinical utility of MAPK pathway mutations in prognosis and potentially in precision immunotherapy.
 

Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse models
Chang S Chan, Yvonne Sun, Hua Ke, Yuhan Zhao, Merzu Belete, Cen Zhang, Zhaohui Feng, Arnold J Levine, Wenwei Hu

This study used mice heterozygous for Tp53 mutations with different genetic backgrounds to investigate the genetic or stochastic factors that modify the penetrance of tumor formation by Tp53 mutation.
 

Insulin signaling mediates neurodegeneration in glioma
Patricia Jarabo, Carmen de Pablo, Héctor Herranz, Francisco Antonio Martín, Sergio Casas-Tintó

Tumoral cells secrete an antagonist that attenuates insulin signaling in neurons. It induces mitochondrial defects and synapse loss; restoring neuronal insulin activity rescues neurodegeneration.
 

The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets
Mariano F Zacarías-Fluck, Toni Jauset, Sandra Martínez-Martín, Jastrinjan Kaur, Sílvia Casacuberta-Serra, Daniel Massó-Vallés, Erika Serrano del Pozo, Génesis Martín-Fernández, Íñigo González-Larreategui, Sergio López-Estévez, Lamorna Brown-Swigart, Marie-Eve Beaulieu, Jonathan R Whitfield, Babita Madan, David M Virshup, Gerard I Evan, Laura Soucek

Zacarías-Fluck, et al identify and validate the Wnt receptor Fzd9 as a key effector of Myc-Wnt signaling cross-talk in a mouse model of Myc-driven pancreatic insulinomas.
 

SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsiveness
Nathaniel J Robinson, Chevaun D Morrison-Smith, Alex J Gooding, Barbara J Schiemann, Mark W Jackson, Derek J Taylor, William P Schiemann

An unbiased genetic screen established SLX4IP as an essential driver of telomere maintenance mechanism identity, metastatic progression, and therapeutic response of breast cancers.
 

Paneth cell–derived growth factors support tumorigenesis in the small intestine
Qing Chen, Kohei Suzuki, Luis Sifuentes-Dominguez, Naoteru Miyata, Jie Song, Adam Lopez, Petro Starokadomskyy, Purva Gopal, Igor Dozmorov, Shuai Tan, Bujun Ge, Ezra Burstein

Paneth cells, known for their production of antimicrobial peptides and growth factors in the gut epithelium, are found to play a key role in intestinal tumor formation through secretion of Wnt3.

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Volume 4, No. 3
March 2021
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