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Decoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinomaPreclinical models demonstrate that obesity reprograms the pretumor or tumor cell and its micro- and macro-environments to drive cancer development via altered cellular metabolism, hormone dysregulation, inflammation, and microbial dysbiosis.
Transducing compressive forces into cellular outputs in cancer and beyondThe review identifies signaling and cell biology processes selectively induced by mechanical compressive forces on normal or pathological tissues such as tumors for the development of novel treatments.
Building in vitro models of the brain to understand the role of APOE in Alzheimer’s diseaseHuman induced pluripotent stem cell (hiPSC)–based models of the brain will be key to unraveling the role of APOE ɛ4 in the interconnected cellular changes underlying Alzheimer’s disease.