More articles from Reviews
Recent approaches in computational modelling for controlling pathogen threatsRecent advances and remaining challenges in using computational approaches to model various aspects of pathogen infection and transmission are discussed and reviewed.
CXCR4: from B-cell development to B cell–mediated diseasesThis review provides an overview of the role of the C-X-C chemokine receptor type 4 (CXCR4) in B-cell development and in B cell–mediated disorders.
Cholesterol and COVID-19—therapeutic opportunities at the host/virus interface during cell entryThe key to cholesterol-related broad-spectrum antiviral strategies may be to disrupt cholesterol handling in specific cellular organelles.
FERM domain–containing proteins are active components of the cell nucleusThe information we gathered from the literature reveals that FERM domain proteins perform important and diverse functions not only in the cytoplasm, but also in the cell nucleus.
Interconnections between m6A RNA modification, RNA structure, and protein–RNA complex assemblyThis review summarizes current knowledge and future directions on the mechanisms that govern the interplay between m6A RNA modification, RNA folding, and protein–RNA interactions, focusing on the mechanisms and available quantitative information.
Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variantsMechanisms and consequences of POLE mutations in human cancers.
Toward an understanding of glucose metabolism in radial glial biology and brain developmentWe review the literature exploring the role of glycolysis and glucose metabolism in cortical development and discuss recent advances and future directions to better understand metabolic disease and neurodevelopment disorders.
Regulation of alternative splicing and polyadenylation in neuronsNeurons generate numerous cell-specific isoforms of genes that are expressed more broadly. Here, we review mechanisms that generate neural-specific alternative splicing and 3′UTRs and their biological impacts on the nervous system.
Molecular mechanisms underlying totipotencyA review article summarizing recent findings related to totipotency in mammals, encompassing topics such as the epigenome and gene regulation in early embryos, in vitro totipotent-like cells, and somatic nuclear transfer.
Decoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinomaPreclinical models demonstrate that obesity reprograms the pretumor or tumor cell and its micro- and macro-environments to drive cancer development via altered cellular metabolism, hormone dysregulation, inflammation, and microbial dysbiosis.