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- Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection
Targeted integration of a tumor-reactive T-cell receptor into the TRAC locus using CRISPR-Cas9 and AAV6 redirects primary human T cells against tumor cells in vitro and in vivo.
- Re-annotation of eight Drosophila genomes
Using a well-annotated genome to inform the annotation of genomes in a phylogeny.
- A carnivorous plant genetic map: pitcher/insect-capture QTL on a genetic linkage map of Sarracenia
This study presents the first genetic map for a carnivorous plant, mapping 64 QTLs in Sarracenia to provide the genetic basis for differences between the pitfall and lobster-trap insect-capture strategies.
- Small RNA-Seq reveals novel miRNAs shaping the transcriptomic identity of rat brain structures
Small RNA-Seq of the rat central nervous system reveals known and novel miRNAs specifically regulated in brain structures and correlated with the expression of their predicted target genes, suggesting a critical role in the transcriptomic identity of brain structures.
- Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers
Application of pressure cycling technology and Sequential Windowed Acquisition of all THeoretical mass spectrometry allows quantifying the degree of intra-tumor heterogeneity of protein expression in prostate tumors. The data show that protein intra-tumor heterogeneity, if not characterized, may distort protein biomarker suitability in tumor tissues.