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Improving the computation efficiency of polygenic risk score modeling: faster in JuliaTo enable computationally efficient polygenic risk score (PRS) calculations, PRS.jl translates a field standard PRS construction method, PRS-CS, to the Julia programming language.
PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous systemPRMT1 regulates MHC-associated microglia cluster during de/remyelination.
Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysisIntegrated analysis of the phosphoproteome and interactome of anaplastic lymphoma kinase (ALK)-overexpressing HEK 293 cells revealed 37 ALK substrate candidates, contributing to the improvement of kinase activity prediction.
LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reportersDescription of affordable ($40) open-source platform for real-time in-cell monitoring of luciferase activity.
Intensive single-cell analysis reveals immune-cell diversity among healthy individualsThis study describes the diversity of the immune-cell profiling in healthy adults at the single-cell level using RNA-seq, VDJ repertoires, and proteome.
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprintingThis study shows that the generation of human long-lived plasma cells requires blood antibody secreting cells to undergo epigenetic and transcriptional reprogramming in response to the bone marrow microniche to become apoptosis resistant and survive to secrete antibodies for a lifetime.
Nonsense-mediated mRNA decay uses complementary mechanisms to suppress mRNA and protein accumulationA reporter system for quantitative measurements of NMD-sensitive mRNA and protein levels in mammalian cells shows that NMD suppresses protein levels to a greater degree than RNA levels.
Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathologySARS-CoV-2 infection alters the levels of sphingolipids early post infection. This phenomenon is reflected by increased levels of sphingolipids, including gangliosides, in infected cells, as well as in serum in a SARS-CoV-2 murine model.
OrtSuite: from genomes to prediction of microbial interactions within targeted ecosystem processesOrtSuite predicts synergistic species interactions using the genomic potential of microbial communities
Dynamic changes in RNA–protein interactions and RNA secondary structure in mammalian erythropoiesisAnalysis of PIP-seq data from a model of erythropoiesis reveals dynamics of RBP–RNA interaction and changes in RNA secondary structure throughout red blood cell development.