More articles from Resources
- Protein and RNA ADP-ribosylation detection is influenced by sample preparation and reagents used
Mono(ADP-ribosyl)ation is an emerging modification, for which recently detection reagents were generated. We cross-validated all reagents and observe remarkable differences in efficiency, depending on the substrate investigated and on the methods that are used.
- Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing
Targeted capture sequencing (CapIG-seq) is a novel, efficient, and effective approach to examine multiple genomic alterations in ctDNA and bone marrow aspirates of patients with multiple myeloma.
- Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells
Single-cell RNA sequencing of porcine ileal lymphocytes reveals similarities to human cells and discovery of porcine intestinal innate lymphoid cells.
- Islet Gene View—a tool to facilitate islet research
Islet Gene View (IGW) is a web resource that makes information on gene expression in human islets from donors easily accessible to the scientific community. The relationship of global RNA expression from 188 donor-islets with islet phenotypes is explored.
- Improving the computation efficiency of polygenic risk score modeling: faster in Julia
To enable computationally efficient polygenic risk score (PRS) calculations, PRS.jl translates a field standard PRS construction method, PRS-CS, to the Julia programming language.
- PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system
PRMT1 regulates MHC-associated microglia cluster during de/remyelination.
- Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis
Integrated analysis of the phosphoproteome and interactome of anaplastic lymphoma kinase (ALK)-overexpressing HEK 293 cells revealed 37 ALK substrate candidates, contributing to the improvement of kinase activity prediction.
- LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reporters
Description of affordable ($40) open-source platform for real-time in-cell monitoring of luciferase activity.
- Intensive single-cell analysis reveals immune-cell diversity among healthy individuals
This study describes the diversity of the immune-cell profiling in healthy adults at the single-cell level using RNA-seq, VDJ repertoires, and proteome.
- Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting
This study shows that the generation of human long-lived plasma cells requires blood antibody secreting cells to undergo epigenetic and transcriptional reprogramming in response to the bone marrow microniche to become apoptosis resistant and survive to secrete antibodies for a lifetime.