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Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicingTranscriptomic analysis of dengue-infected patients reveals altered immune response pathways, transcript diversity, and splicing efficiency, underscoring potential therapeutic targets for treatment.
Twisting the theory on the origin of human umbilical cord coiling featuring monozygotic twinsThis study provides a novel framework to understand the molecular origins of human umbilical cord helices using state-of-the-art imaging and omics approaches.
A multiomic characterization of the leukemia cell line REH using short- and long-read sequencingLong- and short-read sequencing are integrated to detail the genomic and transcriptomic characteristics of the cell line REH, a model for pediatric B-cell acute lymphoblastic leukemia.
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactorsUbiquitin interactor pulldown coupled with mass spectrometry elucidates K48- and K63-linked interactomes including novel heterotypic branch- and chain length–specific binders. This screen lays the foundations for our understanding of how complex Ub architectures are read.
REMEMProt: a resource of membrane-enriched proteome profiles, their disease associations, and biomarker statusA resource of experimental specific membrane-enriched mass spectrometry–derived proteome.
Systems genetics analysis of human body fat distribution genes identifies adipocyte processesUsing Bayesian network analysis, we modeled gene-gene interactions and predicted novel regulators of adipose tissue fat storage. We show that five novel genes affect adipogenesis or mitochondrial function in human fat cells.
iMPAQT reveals that adequate mitohormesis from TFAM overexpression leads to life extension in miceOverexpressing TFAM leads to smaller, leaner mice with extended lifespans. The iMPAQT analysis revealed changes in mitochondrial protein expression and characteristic metabolic shifts indicative of mitohormesis as an adaptive strategy in skeletal muscle.
Comprehensive meta-analysis reveals distinct gene expression signatures of MASLD progressionMeta-analysis of hepatic gene expression reveals novel drivers of progression in metabolic dysfunction-associated liver disease (MASLD).
Genetic structure and diversity of the rfb locus of pathogenic species of the genus LeptospiraThis study provides a broad investigation of the gene composition of the rfb locus, the main genetic factor associated with serology in Leptospira, and opens the way for molecular diagnostics in leptospirosis.
Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencingA widely used anti-MUC1 antibody (139H2) is sequenced by mass spectrometry, revealing the molecular basis of its glycosylation-independent binding to this tumor-associated antigen.