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More articles from Resources

  • Disease- and sex-specific differences in patients with heart valve disease: a proteome study
    Open Access
    Disease- and sex-specific differences in patients with heart valve disease: a proteome study

    Sarah Nordmeyer, Milena Kraus, Matthias Ziehm, Marieluise Kirchner, Marie Schafstedde, Marcus Kelm, Sylvia Niquet, Mariet Mathew Stephen, Istvan Baczko, Christoph Knosalla, Matthieu-P Schapranow, Gunnar Dittmar, Michael Gotthardt, Martin Falcke, Vera Regitz-Zagrosek, Titus Kuehne, Philipp Mertins

    Sarah Nordmeyer ... Philipp Mertins

    Published 10 January 2023

    Proteomics provide novel insights into molecular mechanisms and cardiac remodeling in heart failure because of pressure overload in aortic valve stenosis and volume overload in mitral valve regurgitation.

  • IARA: a complete and curated atlas of the biogenesis of spliceosome machinery during RNA splicing
    Open Access
    IARA: a complete and curated atlas of the biogenesis of spliceosome machinery during RNA splicing

    Kelren S Rodrigues, Luiz P Petroski, Paulo H Utumi, Adriano Ferrasa, Roberto H Herai

    Kelren S Rodrigues ... Roberto H Herai

    Published 6 January 2023

    The online atlas IARA is a curated and updated resource with genetic and molecular data on the biogenesis of human spliceosome machinery involved in RNA splicing.

  • Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing
    Open Access
    Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing

    Jonathan Liu, Vanessa Tran, Venkata Naga Pranathi Vemuri, Ashley Byrne, Michael Borja, Yang Joon Kim, Snigdha Agarwal, Ruofan Wang, Kyle Awayan, Abhishek Murti, Aris Taychameekiatchai, Bruce Wang, George Emanuel, Jiang He, John Haliburton, Angela Oliveira Pisco, Norma F Neff

    Jonathan Liu ... Norma F Neff

    Published 16 December 2022

    Single-cell RNA-seq is an important technology for capturing gene expression in individual cells. It has limitations as spatial context and accurate representation of cell types in the tissue are lost. Here, we show that MERFISH is comparable to scRNA-seq.

  • Transcriptome analyses in infertile men reveal germ cell–specific expression and splicing patterns
    Open Access
    Transcriptome analyses in infertile men reveal germ cell–specific expression and splicing patterns

    Lara M Siebert-Kuss, Henrike Krenz, Tobias Tekath, Marius Wöste, Sara Di Persio, Nicole Terwort, Margot J Wyrwoll, Jann-Frederik Cremers, Joachim Wistuba, Martin Dugas, Sabine Kliesch, Stefan Schlatt, Frank Tüttelmann, Jörg Gromoll, Nina Neuhaus, Sandra Laurentino

    Lara M Siebert-Kuss ... Sandra Laurentino

    Published 29 November 2022

    We uncover extensive germ cell type–dependent transcriptome changes in human spermatogenesis and demonstrate the potential of alternative splicing in the regulation of spermatogenesis.

  • Protein and RNA ADP-ribosylation detection is influenced by sample preparation and reagents used
    Open Access
    Protein and RNA ADP-ribosylation detection is influenced by sample preparation and reagents used

    Lisa Weixler, Nonso Josephat Ikenga, Jim Voorneveld, Gülcan Aydin, Timo MHR Bolte, Jeffrey Momoh, Mareike Bütepage, Alexandra Golzmann, Bernhard Lüscher, Dmitri V Filippov, Roko Žaja, Karla LH Feijs

    Lisa Weixler ... Karla LH Feijs

    Published 11 November 2022

    Mono(ADP-ribosyl)ation is an emerging modification, for which recently detection reagents were generated. We cross-validated all reagents and observe remarkable differences in efficiency, depending on the substrate investigated and on the methods that are used.

  • Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing
    Open Access
    Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing

    Signy Chow, Olena Kis, David T Mulder, Arnavaz Danesh, Jeff Bruce, Ting Ting Wang, Donna Reece, Nizar Bhalis, Paola Neri, Peter JB Sabatini, Jonathan Keats, Suzanne Trudel, Trevor J Pugh

    Signy Chow ... Trevor J Pugh

    Published 3 November 2022

    Targeted capture sequencing (CapIG-seq) is a novel, efficient, and effective approach to examine multiple genomic alterations in ctDNA and bone marrow aspirates of patients with multiple myeloma.

  • Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells
    Open Access
    Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells

    Jayne E Wiarda, Julian M Trachsel, Sathesh K Sivasankaran, Christopher K Tuggle, Crystal L Loving

    Jayne E Wiarda ... Crystal L Loving

    Published 22 August 2022

    Single-cell RNA sequencing of porcine ileal lymphocytes reveals similarities to human cells and discovery of porcine intestinal innate lymphoid cells.

  • Islet Gene View—a tool to facilitate islet research
    Open Access
    Islet Gene View—a tool to facilitate islet research

    Olof Asplund, Petter Storm, Vikash Chandra, Gad Hatem, Emilia Ottosson-Laakso, Dina Mansour-Aly, Ulrika Krus, Hazem Ibrahim, Emma Ahlqvist, Tiinamaija Tuomi, Erik Renström, Olle Korsgren, Nils Wierup, Mark Ibberson, Michele Solimena, Piero Marchetti, Claes Wollheim, Isabella Artner, Hindrik Mulder, Ola Hansson, Timo Otonkoski, Leif Groop, Rashmi B Prasad

    Olof Asplund ... Rashmi B Prasad

    Published 10 August 2022

    Islet Gene View (IGW) is a web resource that makes information on gene expression in human islets from donors easily accessible to the scientific community. The relationship of global RNA expression from 188 donor-islets with islet phenotypes is explored.

  • Improving the computation efficiency of polygenic risk score modeling: faster in Julia
    Open Access
    Improving the computation efficiency of polygenic risk score modeling: faster in Julia

    Annika Faucon, Julian Samaroo, Tian Ge, Lea K Davis, Nancy J Cox, Ran Tao, Megan M Shuey

    Annika Faucon ... Megan M Shuey

    Published 18 July 2022

    To enable computationally efficient polygenic risk score (PRS) calculations, PRS.jl translates a field standard PRS construction method, PRS-CS, to the Julia programming language.

  • PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system
    Open Access
    PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system

    Jeesan Lee, Oscar David Villarreal, Yu Chang Wang, Jiannis Ragoussis, Serge Rivest, David Gosselin, Stéphane Richard

    Jeesan Lee ... Stéphane Richard

    Published 15 June 2022

    PRMT1 regulates MHC-associated microglia cluster during de/remyelination.

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