More articles from Resources
- Comprehensive meta-analysis reveals distinct gene expression signatures of MASLD progression
Meta-analysis of hepatic gene expression reveals novel drivers of progression in metabolic dysfunction-associated liver disease (MASLD).
- Genetic structure and diversity of the rfb locus of pathogenic species of the genus Leptospira
This study provides a broad investigation of the gene composition of the rfb locus, the main genetic factor associated with serology in Leptospira, and opens the way for molecular diagnostics in leptospirosis.
- Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing
A widely used anti-MUC1 antibody (139H2) is sequenced by mass spectrometry, revealing the molecular basis of its glycosylation-independent binding to this tumor-associated antigen.
- A genetic screen to uncover mechanisms underlying lipid transfer protein function at membrane contact sites
A genetic screen in Drosophila photoreceptors uncovers multiple regulators of lipid transfer function and endoplasmic reticulum–plasma membrane contact sites.
- A comparative study of structural variant calling in WGS from Alzheimer’s disease families
We developed a flexible protocol to generate a high-quality deletion call set and a truth set of Sanger sequencing–validated deletions with precise breakpoints between 1 and 17,000 bp from whole-genome sequencing data in multiplex families with Alzheimer’s disease.
- Ageing-dependent thiol oxidation reveals early oxidation of proteins with core proteostasis functions
Proteome-wide analysis of thiol oxidation during chronological ageing of yeast reveals evolutionarily conserved proteins as early-oxidation targets with a potential impact on proteostasis regulation.
- Gene architecture is a determinant of the transcriptional response to bulky DNA damages
A comparative genomic study of the transcriptomic response to bulky DNA damages uncovers novel response genes and the features of their structure that allow them to be better repaired and transcribed.
- Single-cell time series analysis reveals the dynamics of HSPC response to inflammation
Unbiased single-cell time series analysis of gene expression response to inflammation, using novel computational approaches, links myeloid depletion to alterations in differentiation bias and pyroptosis activity.
- Mitochondrial phosphoproteomes are functionally specialized across tissues
This study explores tissue-specific mitochondrial proteomes and phosphoproteomes in unprecedented depth, offering valuable insights into mitochondrial organization and specialization.
- Performance and robustness analysis reveals phenotypic trade-offs in yeast
This study combines phenotypic data from yeast cultivations with quantification of robustness over a defined perturbation space, revealing trade-offs between performance and robustness.