More articles from Resources
Cross-comparison of strains used for mitochondrial imaging in Caenorhabditis elegans during agingThis study evaluates mitochondrial imaging in C. elegans during aging, comparing various transgenic constructs for tissue-specific mitochondrial visualization. The findings highlight technical considerations, imaging method standardization, and the utility of C. elegans as a robust model for studying mitochondrial dynamics.
Cytokine storm and vascular leakage in severe dengue: insights from single-cell RNA profilingFixed single-cell RNA profiling identified IL-17A/F-producing γδ T cells, ILC3s, and Th17 cells, cooperative roles of M1- and M2-like macrophages, and dual roles of neutrophils during severe dengue.
Gastric cancer genomics study using reference human pangenomesUsing a concept called graph pangenome for many individual genomes as the baseline can improve the identification and characterization of large-sized genomic variations for disease genomics study.
Systematic assessment of structural variant annotation tools for genomic interpretationThis study benchmarks eight structural variant prioritization tools, highlighting their comparable effectiveness in predicting pathogenicity and providing insights for improved genomic research.
Mass spectrometry–based proteomic exploration of diverse murine macrophage cellular modelsIn this article, we characterised multiple murine macrophage cell models by proteomics and identified significant differences compared with bone marrow–derived macrophages.
Clonal landscape of autoantibody-secreting plasmablasts in COVID-19 patientsThis study identifies a public autoantibody clonotype that sheds light on the development of COVID-19–associated autoantibodies through single-cell immunoglobulin repertoire analysis of plasmablasts.
Quantitative assessment of the nanoanatomy of the contractile vacuole complex in Trypanosoma cruziElectron microscopy analysis of the osmoregulatory system in T. cruzi cell lines subjected to cryopreparation methods revealed dynamic changes in the contractile vacuole complex (CVC) and the structure of the adhesion plaque domain during the CVC pulsation cycle.
Gene expression and chromatin conformation of microglia in virally suppressed people with HIVLeveraging our rapid autopsy “Last Gift” cohort at UCSD, we identified distinct microglial gene expression profiles despite ART.
A large-scale cancer-specific protein–DNA interaction networkThis study delineates a large-scale cancer gene TF-DNA interaction network, highlighting potential oncogene-targeted therapeutics and complex TF roles in gene regulation. This study also offers a valuable resource for future research in cancer gene regulation and for therapeutic development.
Transient chromatin decompaction at the start of D. melanogaster male embryonic germline developmentOur genomics profiling of the earliest fruit fly germline revealed a brief window of major chromatin remodeling in the male germline right after zygotic activation and suggests reprogramming in the early stages of germline to be an evolutionarily conserved phenomenon.