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More articles from Resources

  • Islet Gene View—a tool to facilitate islet research
    Open Access
    Islet Gene View—a tool to facilitate islet research

    Olof Asplund, Petter Storm, Vikash Chandra, Gad Hatem, Emilia Ottosson-Laakso, Dina Mansour-Aly, Ulrika Krus, Hazem Ibrahim, Emma Ahlqvist, Tiinamaija Tuomi, Erik Renström, Olle Korsgren, Nils Wierup, Mark Ibberson, Michele Solimena, Piero Marchetti, Claes Wollheim, Isabella Artner, Hindrik Mulder, Ola Hansson, Timo Otonkoski, Leif Groop, Rashmi B Prasad

    Olof Asplund ... Rashmi B Prasad

    Published 10 August 2022

    Islet Gene View (IGW) is a web resource that makes information on gene expression in human islets from donors easily accessible to the scientific community. The relationship of global RNA expression from 188 donor-islets with islet phenotypes is explored.

  • Improving the computation efficiency of polygenic risk score modeling: faster in Julia
    Open Access
    Improving the computation efficiency of polygenic risk score modeling: faster in Julia

    Annika Faucon, Julian Samaroo, Tian Ge, Lea K Davis, Nancy J Cox, Ran Tao, Megan M Shuey

    Annika Faucon ... Megan M Shuey

    Published 18 July 2022

    To enable computationally efficient polygenic risk score (PRS) calculations, PRS.jl translates a field standard PRS construction method, PRS-CS, to the Julia programming language.

  • PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system
    Open Access
    PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system

    Jeesan Lee, Oscar David Villarreal, Yu Chang Wang, Jiannis Ragoussis, Serge Rivest, David Gosselin, Stéphane Richard

    Jeesan Lee ... Stéphane Richard

    Published 15 June 2022

    PRMT1 regulates MHC-associated microglia cluster during de/remyelination.

  • Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis
    Open Access
    Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis

    Jun Adachi, Akemi Kakudo, Yoko Takada, Junko Isoyama, Narumi Ikemoto, Yuichi Abe, Ryohei Narumi, Satoshi Muraoka, Daigo Gunji, Yasuhiro Hara, Ryohei Katayama, Takeshi Tomonaga

    Jun Adachi ... Takeshi Tomonaga

    Published 4 May 2022

    Integrated analysis of the phosphoproteome and interactome of anaplastic lymphoma kinase (ALK)-overexpressing HEK 293 cells revealed 37 ALK substrate candidates, contributing to the improvement of kinase activity prediction.

  • LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reporters
    Open Access
    LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reporters

    Kamila Weissová, Bohumil Fafílek, Tomasz Radaszkiewicz, Canan Celiker, Petra Macháčková, Tamara Čechová, Jana Šebestíková, Aleš Hampl, Vítězslav Bryja, Pavel Krejčí, Tomáš Bárta

    Kamila Weissová ... Tomáš Bárta

    Published 19 April 2022

    Description of affordable ($40) open-source platform for real-time in-cell monitoring of luciferase activity.

  • Intensive single-cell analysis reveals immune-cell diversity among healthy individuals
    Open Access
    Intensive single-cell analysis reveals immune-cell diversity among healthy individuals

    Yukie Kashima, Keiya Kaneko, Patrick Reteng, Nina Yoshitake, Lucky Ronald Runtuwene, Satoi Nagasawa, Masaya Onishi, Masahide Seki, Ayako Suzuki, Sumio Sugano, Mamiko Sakata-Yanagimoto, Yumiko Imai, Kaori Nakayama-Hosoya, Ai Kawana-Tachikawa, Taketoshi Mizutani, Yutaka Suzuki

    Yukie Kashima ... Yutaka Suzuki

    Published 5 April 2022

    This study describes the diversity of the immune-cell profiling in healthy adults at the single-cell level using RNA-seq, VDJ repertoires, and proteome.

  • Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting
    Open Access
    Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting

    Chester J Joyner, Ariel M Ley, Doan C Nguyen, Mohammad Ali, Alessia Corrado, Christopher Tipton, Christopher D Scharer, Tian Mi, Matthew C Woodruff, Jennifer Hom, Jeremy M Boss, Meixue Duan, Greg Gibson, Danielle Roberts, Joel Andrews, Sagar Lonial, Inaki Sanz, F Eun-Hyung Lee

    Chester J Joyner ... F Eun-Hyung Lee

    Published 24 December 2021

    This study shows that the generation of human long-lived plasma cells requires blood antibody secreting cells to undergo epigenetic and transcriptional reprogramming in response to the bone marrow microniche to become apoptosis resistant and survive to secrete antibodies for a lifetime.

  • Nonsense-mediated mRNA decay uses complementary mechanisms to suppress mRNA and protein accumulation
    Open Access
    Nonsense-mediated mRNA decay uses complementary mechanisms to suppress mRNA and protein accumulation

    Dylan B Udy, Robert K Bradley

    Dylan B Udy ... Robert K Bradley

    Published 8 December 2021

    A reporter system for quantitative measurements of NMD-sensitive mRNA and protein levels in mammalian cells shows that NMD suppresses protein levels to a greater degree than RNA levels.

  • Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology
    Open Access
    Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology

    Einat B Vitner, Roy Avraham, Boaz Politi, Sharon Melamed, Tomer Israely

    Einat B Vitner ... Tomer Israely

    Published 11 November 2021

    SARS-CoV-2 infection alters the levels of sphingolipids early post infection. This phenomenon is reflected by increased levels of sphingolipids, including gangliosides, in infected cells, as well as in serum in a SARS-CoV-2 murine model.

  • OrtSuite: from genomes to prediction of microbial interactions within targeted ecosystem processes
    Open Access
    OrtSuite: from genomes to prediction of microbial interactions within targeted ecosystem processes

    João Pedro Saraiva, Alexandre Bartholomäus, René Kallies, Marta Gomes, Marcos Bicalho, Jonas Coelho Kasmanas, Carsten Vogt, Antonis Chatzinotas, Peter Stadler, Oscar Dias, Ulisses Nunes da Rocha

    João Pedro Saraiva ... Ulisses Nunes da Rocha

    Published 27 September 2021

    OrtSuite predicts synergistic species interactions using the genomic potential of microbial communities

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