More articles from Research Articles
- Congress of multiple dimers is needed for cross-phosphorylation of IRE1α and its RNase activity
This work shows that dimerization is not sufficient to activate IRE1α and congregation of dimers is needed to trigger cross-phosphorylation and unleash endonuclease activity of this ER stress sensor.
- Single-housing–induced islet epigenomic changes are related to polymorphisms in diabetic KK mice
This study demonstrates that non-coding variants in KK mice, a polygenic model of type 2 diabetes, may be involved in the development of diabetes via epigenetic mechanisms during social isolation.
- The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis
ILC1 activation by the oxygen-sensitive transcription factor HIF-1α is detrimental upon acute colitis, but protects against inflammation and fibrosis during chronic colitis.
- Calaxin is a key factor for calcium-dependent waveform control in zebrafish sperm
This study demonstrates that Calaxin’s calcium-binding activity is necessary for the calcium-induced asymmetric beating of cilia but dispensable to stabilize outer arm dynein.
- Exploring the molecular composition of the multipass translocon in its native membrane environment
Cryo-ET reveals the compositional variability of the multipass translocon complex dependent on translational activity of the bound ribosome and suggests the location of its subunit NOMO.
- The nucleolar phase of signal recognition particle assembly
Signal recognition particle (SRP) involved in tethering the ribosome to the endoplasmic reticulum for protein secretion is assembled in part in the nucleolus where it interacts with numerous ribosome assembly factors.
- STAT3 inhibition recovers regeneration of aged muscles by restoring autophagy in muscle stem cells
This study shows that STAT3 regulates MuSC function by both transcription-dependent and transcription-independent control of autophagy. STAT3 inhibition reverses age-dependent impairment of muscle regeneration, by restoring autophagy in aged MuSCs.
- Mitochondrial lipidomes are tissue specific – low cholesterol contents relate to UCP1 activity
The mitochondria’s lipid composition is key for brown adipose tissue function. High cholesterol contents block UCP1 activity, whereas increasing phosphatidyl-choline and -ethanolamine levels boost it.
- Nono induces Gadd45b to mediate DNA repair
RNA-binding proteins are often deregulated in tumours, and this study reveals that the multifunctional splicing factor Nono promotes the induction of the DNA repair factor Gadd45b to prevent genome instability in murine non–small-cell lung cancer cells.
- Off-targets of BRAF inhibitors disrupt endothelial signaling and vascular barrier function
Clinically used therapies against BRAF-mutant melanoma have differential off-target effects on the phosphoproteome of endothelial cells, cell-cell junction architecture and vascular permeability.