More articles from Research Articles
Branch point strength controls species-specific CAMK2B alternative splicing and regulates LTPA mechanism that contributes to species-specific alternative splicing leading to increased coding capacity of primate genomes is presented and functionality for CamK2β splicing addressed.
An isoform-specific function of Cdc42 in regulating mammalian Exo70 during axon formationThe brain-specific isoform of the GTPase Cdc42 is shown to promote axon formation by interacting with the exocyst tethering complex and increasing exocytosis downstream of its activator Arhgef7.
Integrin ligands block mechanical signal transduction in baroreceptorsThe binding of integrins to specific sequences in extracellular matrix forms the mechanical coupling to transfer stretch applied on the vascular wall to the baroreceptors.
Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout ratsTSPAN7 knockout causes ASD-like phenotypes in rats through the integrin β1/FAK/SRC signal pathway, which provides novel insights into the role of TSPAN7 in psychiatric diseases, highlighting SRC as a potential target.
Tyrosine phosphorylation controlled poly(A) polymerase I activity regulates general stress response in bacteriaWe show a tyrosine phosphorylation–controlled poly(A) polymerase I polyadenylation activity regulated stress response mechanism in bacteria that is distinct and operates downstream of the primary stress regulator RpoS.
Convergent evolution and horizontal gene transfer in Arctic Ocean microalgaeThe Arctic Ocean stands apart from other oceans. Using multiple genomes and transcriptomes from cultured and environmental sources, we found distinct genetic modifications in Arctic microalgae consistent with biogeographically constrained trait selectivity as an adaptive force in algal evolution.
Ectopic CH60 mediates HAPLN1-induced cell survival signaling in multiple myelomaThis study defines ectopic mitochondrial chaperonin 60 (CH60) on the multiple myeloma cell surface as a HAPLN1 matrikine receptor that signals via TLR4 to induce NF-κB signaling and drug resistance.
Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19Severe COVID-19 is associated with alterations to the neutrophil compartment with circulating hyperactive immature neutrophils and a maintenance of CXCR2 expression.
Identifying novel regulators of placental development using time-series transcriptome dataNetwork analysis of RNA-seq data generated from mouse placenta at embryonic days 7.5, 8.5, and 9.5 identifies novel regulators of placental development.
Horizontal transfer of the rfb cluster in Leptospira is a genetic determinant of serovar identityLeptospira strains show very large antigenic variation (serovars). Here, the rfb gene cluster is shown to be transferred horizontally within/among Leptospira species, discriminating serovar identity.