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Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasisPathologic β-cells become long-lived in diabetes despite high energy conservation based on the control over their metabolic state via PFKFB3 and suppression of Ca2+ toxicity via MAIP1. Inhibition of PFKFB3 eradicates dysfunctional β-cells restoring glucose tolerance in a T2D model.
PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fatesPRDM16 loss in cardiomyocytes during development causes an atrial and conduction fate shift and distal ventricular conduction system hyperplasia resulting in premature death or cardiac dysfunction.
Ccrk-Mak/Ick signaling is a ciliary transport regulator essential for retinal photoreceptor survivalThis study shows that the ciliopathy kinases Mak and Ick cooperatively act as ciliary tip-localized IFT regulators that are phosphorylated and activated by Ccrk in retinal photoreceptor cells.
Nanoscale imaging of DNA-RNA identifies transcriptional plasticity at heterochromatinImaging mass spectrometry quantifies spatial relationships between DNA and newly formed RNA in the nucleus and illuminates transcription plasticity at condensed DNA.
Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progressionCrosstalk between bone metastatic cancer cells and sensory nerves has not yet been fully elucidated. We demonstrate the involvement of CGRP-expressing sensory nerves in bone metastatic progression and identify the CGRP/CRLR axis as a potential therapeutic target for bone metastasis.
Structural roles of Ump1 and β-subunit propeptides in proteasome biogenesisA 2.1 Å cryo-EM structure of a late proteasome precursor reveals roles of the assembly chaperone Ump1 and β-subunit propeptides in proteasome biogenesis.
Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1bThe study represents the first functional dissection of the two human cofactors present in the RNA decapping complex, and, significantly, it evaluates their role in the transcript buffering system.
Mast cell extracellular trap formation underlies vascular and neural injury and hyperalgesia in sickle cell diseaseMast cell extracellular traps catalyzed by peptidylarginine deiminase 4 contribute to vascular stasis and nerve injury, which may contribute to acute and chronic pain in sickle cell disease.
Regulation of proteostasis by sleep through autophagy in Drosophila models of Alzheimer’s diseaseSleep modulation alters Tau-induced neurodegeneration in Drosophila models of tauopathy.
Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progressionThe accumulation of mitochondrial double-stranded RNA (mt-dsRNA) in cancer cells depends on cell proliferation status. Mt-dsRNA is more abundant in patient lung adenocarcinoma compared with healthy tissue.