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More articles from Research Articles

  • Phylogenetic profiling resolves early emergence of PRC2 and illuminates its functional core
    Open Access
    Phylogenetic profiling resolves early emergence of PRC2 and illuminates its functional core

    Abdoallah Sharaf, Mallika Vijayanathan, Miroslav Oborník, Iva Mozgová

    Abdoallah Sharaf ... Iva Mozgová

    Published 19 April 2022

    This study strengthens the support for PRC2 emergence before the diversification of eukaryotes, detects a common presence of E(z) and ESC, indicating a conserved core, identifies diverse VEFS-Box Su(z)12 candidate proteins, and proposes a substrate specificity shift during E(z) evolution.

  • SMN-deficient cells exhibit increased ribosomal DNA damage
    Open Access
    SMN-deficient cells exhibit increased ribosomal DNA damage

    Evangelia Karyka, Nelly Berrueta Ramirez, Christopher P Webster, Paolo M Marchi, Emily J Graves, Vinay K Godena, Lara Marrone, Anushka Bhargava, Swagat Ray, Ke Ning, Hannah Crane, Guillaume M Hautbergue, Sherif F El-Khamisy, Mimoun Azzouz

    Evangelia Karyka ... Mimoun Azzouz

    Published 19 April 2022

    SMN deficiency leads to elevated ribosomal DNA damage that results in impaired ribosomal RNA synthesis and translation and is accompanied by a motor neuron-specific down-regulation of DDX21 protein.

  • Tricalbin proteins regulate plasma membrane phospholipid homeostasis
    Open Access
    Tricalbin proteins regulate plasma membrane phospholipid homeostasis

    Ffion B Thomas, Deike J Omnus, Jakob M Bader, Gary HC Chung, Nozomu Kono, Christopher J Stefan

    Ffion B Thomas ... Christopher J Stefan

    Published 19 April 2022

    The extended synaptotagmin (E-Syt) family are conserved proteins that function at membrane contacts. This study reveals that yeast E-Syt family members regulate phospholipid homeostasis necessary for plasma membrane integrity.

  • Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis
    Open Access
    Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis

    Nina Tanaskovic, Mattia Dalsass, Marco Filipuzzi, Giorgia Ceccotti, Alessandro Verrecchia, Paola Nicoli, Mirko Doni, Daniela Olivero, Diego Pasini, Haruhiko Koseki, Arianna Sabò, Andrea Bisso, Bruno Amati

    Nina Tanaskovic ... Bruno Amati

    Published 14 April 2022

    Max dimerizes with Mga to form the repressive complex PRC1.6; another PRC1.6 subunit, Pcgf6, suppresses Myc-induced lymphomagenesis but, unexpectedly, does so in a Mga- and PRC1.6-independent manner.

  • A novel domain within the CIL regulates egress of IFITM3 from the Golgi and reveals a regulatory role of IFITM3 on the secretory pathway
    Open Access
    A novel domain within the CIL regulates egress of IFITM3 from the Golgi and reveals a regulatory role of IFITM3 on the secretory pathway

    Li Zhong, Yuxin Song, Federico Marziali, Rustem Uzbekov, Xuan-Nhi Nguyen, Chloé Journo, Philippe Roingeard, Andrea Cimarelli

    Li Zhong ... Andrea Cimarelli

    Published 8 April 2022

    In this work, it is revealed that the broad viral inhibitor IFITM3 is a previously unrecognized modulator of the functionalities of the cellular ER–Golgi secretory pathway.

  • The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity
    Open Access
    The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity

    Helena Dragic, Audrey Barthelaix, Cédric Duret, Simon Le Goupil, Hadrien Laprade, Sophie Martin, Sabine Brugière, Yohann Couté, Christelle Machon, Jerome Guitton, Justine Rudewicz, Paul Hofman, Serge Lebecque, Cedric Chaveroux, Carole Ferraro-Peyret, Toufic Renno, Serge N Manié

    Helena Dragic ... Serge N Manié

    Published 8 April 2022

    We present adaptive mechanisms of resistance of lung adenocarcinoma to their harsh microenvironment, which typically contains a lower glucose concentration compared with normal tissue.

  • Functional and structural deficiencies of Gemin5 variants associated with neurological disorders
    Open Access
    Functional and structural deficiencies of Gemin5 variants associated with neurological disorders

    Rosario Francisco-Velilla, Azman Embarc-Buh, Francisco del Caño-Ochoa, Salvador Abellan, Marçal Vilar, Sara Alvarez, Alberto Fernandez-Jaen, Sukhleen Kour, Deepa S Rajan, Udai Bhan Pandey, Santiago Ramón-Maiques, Encarnacion Martinez-Salas

    Rosario Francisco-Velilla ... Encarnacion Martinez-Salas

    Published 7 April 2022

    Gemin5 clinical variants perturbing the dimerization module and the noncanonical RNA-binding site impair oligomerization, RNA–protein interaction networks, ribosome association, and protein stability.

  • Profiles of telomeric repeats in Insecta reveal diverse forms of telomeric motifs in Hymenopterans
    Open Access
    Profiles of telomeric repeats in Insecta reveal diverse forms of telomeric motifs in Hymenopterans

    Yihang Zhou, Yi Wang, Xiao Xiong, Arthur G Appel, Chao Zhang, Xu Wang

    Yihang Zhou ... Xu Wang

    Published 1 April 2022

    A bioinformatic pipeline for telomeric repeat motif detection was applied to 129 insect species and identified diverse forms of telomeric motifs in Hymenopterans, including canonical 5-bp, novel 8- and 9-bp forms, suggesting extraordinary evolutionary fluidity of telomeric repeat in Hymenopterans.

  • Quantitative analysis of nuclear pore complex organization in <em>Schizosaccharomyces pombe</em>
    Open Access
    Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe

    Joseph M Varberg, Jay R Unruh, Andrew J Bestul, Azqa A Khan, Sue L Jaspersen

    Joseph M Varberg ... Sue L Jaspersen

    Published 30 March 2022

    Characterization of nuclear pores in Schizosaccharomyces pombe identifies regions of heterogeneous NPC density and composition and shows that NPCs are excluded near the spindle pole body by Lem2-mediated centromere tethering.

  • ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway
    Open Access
    ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway

    Marta Wróbel, Jarosław Cendrowski, Ewelina Szymańska, Malwina Grębowicz-Maciukiewicz, Noga Budick-Harmelin, Matylda Macias, Aleksandra Szybińska, Michał Mazur, Krzysztof Kolmus, Krzysztof Goryca, Michalina Dąbrowska, Agnieszka Paziewska, Michał Mikula, Marta Miączyńska

    Marta Wróbel ... Marta Miączyńska

    Published 30 March 2022

    ESCRT-I deficiency impairs lysosome membrane turnover and induces homeostatic responses to lysosomal nutrient starvation including activation of MiT-TFE signaling caused by inhibition of the substrate-specific mTORC1 pathway.

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