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More articles from Research Articles

  • <em>PACSIN2</em> as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells
    Open Access
    PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells

    Giulia Zudeh, Raffaella Franca, Marianna Lucafò, Erik J Bonten, Matteo Bramuzzo, Riccardo Sgarra, Cristina Lagatolla, Martina Franzin, William E Evans, Giuliana Decorti, Gabriele Stocco

    Giulia Zudeh ... Gabriele Stocco

    Published 3 January 2023

    This study evaluates the role of PACSIN2 in autophagy modulation and its impact on mercaptopurine cytotoxicity in lymphoid and intestinal models.

  • Epigenetic centromere identity is precisely maintained through DNA replication but is uniquely specified among human cells
    Open Access
    Epigenetic centromere identity is precisely maintained through DNA replication but is uniquely specified among human cells

    Megan A Mahlke, Lior Lumerman, Peter Ly, Yael Nechemia-Arbely

    Megan A Mahlke ... Yael Nechemia-Arbely

    Published 3 January 2023

    Plasticity in the position of CENP-A enrichment and location of kinetochore recruitment between human cell lines is accompanied by precise CENP-A maintenance across the cell cycle to preserve unique epigenetic centromere identities among human cells.

  • Regulation of telomere silencing by the core histones–autophagy–Sir2 axis
    Open Access
    Regulation of telomere silencing by the core histones–autophagy–Sir2 axis

    Qianyun Mei, Qi Yu, Xin Li, Jianguo Chen, Xilan Yu

    Qianyun Mei ... Xilan Yu

    Published 30 December 2022

    This work reported that there is a global loss of core histones and progressively reduced telomere silencing during yeast chronological aging and uncovered the core histones-autophagy-Sir2 pathway that contributes to the aging-coupled loss of telomere silencing.

  • A SNX1–SNX2–VAPB partnership regulates endosomal membrane rewiring in response to nutritional stress
    Open Access
    A SNX1–SNX2–VAPB partnership regulates endosomal membrane rewiring in response to nutritional stress

    Juliane Da Graça, Juliette Charles, Morgane Djebar, Karla Alvarez-Valadez, Joëlle Botti, Etienne Morel

    Juliane Da Graça ... Etienne Morel

    Published 30 December 2022

    A specific SNX1-dependent endosome tubulation towards autophagosome biogenesis-associated regions of the ER is generated by nutrient deprivation and regulated by the SNX2/VAPB tethering complex.

  • De novo discovery of traits co-occurring with chronic obstructive pulmonary disease
    Open Access
    De novo discovery of traits co-occurring with chronic obstructive pulmonary disease

    Evgeniia Golovina, Tayaza Fadason, Rachel K Jaros, Haribalan Kumar, Joyce John, Kelly Burrowes, Merryn Tawhai, Justin M O’Sullivan

    Evgeniia Golovina ... Justin M O’Sullivan

    Published 27 December 2022

    This paper integrates different levels of biological information to identify shared genetic and biological pathways underlying the diverse clinical presentations of COPD. Thus, it identifies a collection of genetic variants and genes that may aid COPD patient stratification and treatment.

  • Mutation-agnostic RNA interference with engineered replacement rescues <em>Tmc1</em>-related hearing loss
    Open Access
    Mutation-agnostic RNA interference with engineered replacement rescues Tmc1-related hearing loss

    Yoichiro Iwasa, Miles J Klimara, Hidekane Yoshimura, William D Walls, Ryotaro Omichi, Cody A West, Seiji B Shibata, Paul T Ranum, Richard JH Smith

    Yoichiro Iwasa ... Richard JH Smith

    Published 27 December 2022

    Mutation-agnostic RNA interference with concomitant, knockdown-resistant gene replacement, results in robust auditory brainstem response and cochlear hair cell preservation in the murine model of TMC1-related autosomal dominant hearing loss.

  • Kindlin2 enables EphB/ephrinB bi-directional signaling to support vascular development
    Open Access
    Kindlin2 enables EphB/ephrinB bi-directional signaling to support vascular development

    Wenqing Li, Lai Wen, Bhavisha Rathod, Anne-Claude Gingras, Klaus Ley, Ho-Sup Lee

    Wenqing Li ... Ho-Sup Lee

    Published 27 December 2022

    Kindlin2 supports EphB4/ephrinB2 bi-directional signaling functions by associating with a highly conserved NIYY motif in the ephrinB2 cytoplasmic tail to promote ephrinB2 clustering and EphB4 activation, thereby enabling arteriovenous segregation during embryonic development.

  • Trans-differentiation of trophoblast stem cells: implications in placental biology
    Open Access
    Trans-differentiation of trophoblast stem cells: implications in placental biology

    Madhurima Paul, Shreeta Chakraborty, Safirul Islam, Rupasri Ain

    Madhurima Paul ... Rupasri Ain

    Published 27 December 2022

    Formation of trophendothelial cells is associated with trophoblast differentiation and is regulated by HES1. Trophoblast differentiation–induced TRAIL secretion directs preferential demise of ECs located in their vicinity, aiding trophoblast vasculogenic mimicry.

  • Loss of surface transport is a main cellular pathomechanism of CRB2 variants causing podocytopathies
    Open Access
    Loss of surface transport is a main cellular pathomechanism of CRB2 variants causing podocytopathies

    Annika Möller-Kerutt, Birgit Schönhoff, Yvonne Rellmann, Britta George, Daniela Anne Braun, Hermann Pavenstädt, Thomas Weide

    Annika Möller-Kerutt ... Thomas Weide

    Published 22 December 2022

    CRB2 is an essential protein of the renal filtration barrier. This study reports the development of an in vitro assay, suitable to investigate the pathogenic potential of known and novel, so far uncharacterized CRB2 variants.

  • Unconventional interactions of the TRPV4 ion channel with beta-adrenergic receptor ligands
    Open Access
    Unconventional interactions of the TRPV4 ion channel with beta-adrenergic receptor ligands

    Miguel Benítez-Angeles, Emmanuel Juárez-González, Ariela Vergara-Jaque, Itzel Llorente, Gisela Rangel-Yescas, Stéphanie C Thébault, Marcia Hiriart, León D Islas, Tamara Rosenbaum

    Miguel Benítez-Angeles ... Tamara Rosenbaum

    Published 22 December 2022

    The transient receptor potential vanilloid (TRPV4) ion channel is important for respiratory function. Here, it is shown that TRPV4 is inhibited by bronchodilators widely used in diseases such as asthma.

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