More articles from Research Articles
PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cellsThis study evaluates the role of PACSIN2 in autophagy modulation and its impact on mercaptopurine cytotoxicity in lymphoid and intestinal models.
Epigenetic centromere identity is precisely maintained through DNA replication but is uniquely specified among human cellsPlasticity in the position of CENP-A enrichment and location of kinetochore recruitment between human cell lines is accompanied by precise CENP-A maintenance across the cell cycle to preserve unique epigenetic centromere identities among human cells.
Regulation of telomere silencing by the core histones–autophagy–Sir2 axisThis work reported that there is a global loss of core histones and progressively reduced telomere silencing during yeast chronological aging and uncovered the core histones-autophagy-Sir2 pathway that contributes to the aging-coupled loss of telomere silencing.
A SNX1–SNX2–VAPB partnership regulates endosomal membrane rewiring in response to nutritional stressA specific SNX1-dependent endosome tubulation towards autophagosome biogenesis-associated regions of the ER is generated by nutrient deprivation and regulated by the SNX2/VAPB tethering complex.
De novo discovery of traits co-occurring with chronic obstructive pulmonary diseaseThis paper integrates different levels of biological information to identify shared genetic and biological pathways underlying the diverse clinical presentations of COPD. Thus, it identifies a collection of genetic variants and genes that may aid COPD patient stratification and treatment.
Mutation-agnostic RNA interference with engineered replacement rescues Tmc1-related hearing lossMutation-agnostic RNA interference with concomitant, knockdown-resistant gene replacement, results in robust auditory brainstem response and cochlear hair cell preservation in the murine model of TMC1-related autosomal dominant hearing loss.
Kindlin2 enables EphB/ephrinB bi-directional signaling to support vascular developmentKindlin2 supports EphB4/ephrinB2 bi-directional signaling functions by associating with a highly conserved NIYY motif in the ephrinB2 cytoplasmic tail to promote ephrinB2 clustering and EphB4 activation, thereby enabling arteriovenous segregation during embryonic development.
Trans-differentiation of trophoblast stem cells: implications in placental biologyFormation of trophendothelial cells is associated with trophoblast differentiation and is regulated by HES1. Trophoblast differentiation–induced TRAIL secretion directs preferential demise of ECs located in their vicinity, aiding trophoblast vasculogenic mimicry.
Loss of surface transport is a main cellular pathomechanism of CRB2 variants causing podocytopathiesCRB2 is an essential protein of the renal filtration barrier. This study reports the development of an in vitro assay, suitable to investigate the pathogenic potential of known and novel, so far uncharacterized CRB2 variants.
Unconventional interactions of the TRPV4 ion channel with beta-adrenergic receptor ligandsThe transient receptor potential vanilloid (TRPV4) ion channel is important for respiratory function. Here, it is shown that TRPV4 is inhibited by bronchodilators widely used in diseases such as asthma.