More articles from Research Articles
- Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors
This work highlights the importance of the mitochondrial unfolded protein response in allowing organisms to survive external stressors through up-regulation of other stress response pathways.
- SATB1-dependent mitochondrial ROS production controls TCR signaling in CD4 T cells
SATB1 regulates mitochondrial function and reactive oxygen species (ROS) production through the expression of mitochondrial transcription factor A. SATB1-mediated ROS production is necessary for TCR stimulation and T-cell function.
- Functional and metabolic fitness of human CD4+ T lymphocytes during metabolic stress
Human T-cell activation, expansion, and effector function is grossly impaired in conditions that combine glucose deprivation and mild mitochondrial stress.
- Gradual compaction of the central spindle decreases its dynamicity in PRC1 and EB1 gene-edited cells
Although different anaphase proteins bind with characteristically different strength to the central spindle, the overall central spindle dynamicity slows down as mitosis proceeds.
- MKP-1 modulates ubiquitination/phosphorylation of TLR signaling
MKP-1 is a dual-specific phosphatase best known to dephosphorylate p38 and JNK. This study shows for the first time that MKP-1 modulates the landscape of ubiquitin ligases (TRAF6) and deubiquitinase enzymes, as well as upstream TLR signaling molecules.
- ATAD2 controls chromatin-bound HIRA turnover
Parallel study of multiple model systems points to the evolutionary conserved protein ATAD2, as a critical histone chaperone auxiliary factor.
- INPP5K and Atlastin-1 maintain the nonuniform distribution of ER–plasma membrane contacts in neurons
CIL-1 and ATLN-1 maintain the balance between ER tubules and sheets and prevent invasion of cortical ER sheets into the axon, contributing to the non-uniform distribution of neuronal ER-PM contacts.
- Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice
Optogenetic activation of FGFR2 allowed temporally precise induction of signaling and behavioural changes, but counter-regulation at multiple levels prevented a sustained response in keratinocytes.
- Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infection
Cytotoxic killer CD8+ T cells (CTLs) are central effectors that eliminate virus infected cells. In HIV infection, HIV-specific CTLs become functionally impaired. Herein we investigated the link between metabolism and CD8+ T-cell functional impairment, known as exhaustion.
- Choroid plexus APP regulates adult brain proliferation and animal behavior
Adult mouse choroid plexus shows elevated APP expression. sAPPα secreted into the CSF modulates neurogenic niche proliferation, whereas choroid plexus expression of fAD APP mutants leads to reduced niche proliferation, deficits in hippocampus synaptic plasticity, and learning defects.