More articles from Research Articles
- CNVs with adaptive potential in Rangifer tarandus: genome architecture and new annotated assembly
Next-generation sequencing of three caribou ecotypes aligned to a new annotated genome assembly revealed divergent CNVs, including genes with annotations in line with adaptation.
- Fms-like tyrosine kinase 3 is a regulator of the cardiac side population in mice
This work shows that Flt3 signaling regulates the composition and functionality of the cardiac side population, which could be relevant for cardiovascular homeostasis under Flt3-inhibitory therapies.
- Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in Caenorhabditis elegans
Contrary to prior reports, this study shows that a loss of COMPASS components or SET1 activity reduces Caenorhabditis elegans lifespan, suggesting that as in yeast, H3K4 methylation is essential for normal longevity.
- β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy
GPCRs regulator, β-arrestin1, is increased in FTLD-tau patients, is required for β2-adrenergic receptor and metabotropic glutamate receptor 2-induced tau phosphorylation, promotes tau aggregation by impairing autophagy, and destabilizes microtubule dynamics, whereas genetic reduction in β-arrestin1 mitigates tauopathy and cognitive impairments.
- Exosomes/microvesicles target SARS-CoV-2 via innate and RNA-induced immunity with PIWI-piRNA system
Murine neural stem cell exosomes/microvesicles can work to reduce SARS-CoV-2, an effect that can be adaptively enhanced via viral RNA fragment stimulation, which requires the PIWI-piRNA system.
- Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites
Infusions from two Artemisia species, one containing artemisinin, the other not, equally inhibit pre-erythrocytic and erythrocytic stages of different Plasmodium species, including two relapsing species.
- Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage
The blood–brain barrier endothelial cell monolayer becomes permeable to elevated copper loosely bound to albumin, which can be avoided by a high-affinity copper chelator but not by D-penicillamine.
- Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in rats
Liver tissue transcriptomics of liver cirrhosis (LC)–based acute-on-chronic liver failure (ACLF) rats reveal immune-metabolism disorder as the core mechanism underlying ACLF development and prognosis.
- Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma
Using microfluidic affinity profiling, we show how the antibody affinity varies significantly between different individuals after COVID-19 infection while the antibodies neutralise the virus.
- RNA-binding protein Mub1 and the nuclear RNA exosome act to fine-tune environmental stress response
Comparative RNA interactome capture identifies potential regulators of RNA metabolism in fission yeast and reveals RNA exosome–dependent buffering of stress-responsive gene expression networks.