More articles from Research Articles
- New insights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain
This study investigates phosphorylation of and kindlin recruitment by the double-threonine motif in the β1 integrin cytoplasmic tails.
- Rbfox1 is required for myofibril development and maintaining fiber type–specific isoform expression in Drosophila muscles
Rbfox1 is required for the development of both fibrillar and tubular muscle fibers in adult Drosophila and interacts with Bruno1 to define fiber type–specific patterns of alternative splicing.
- Retinoblastoma protein regulates carcinogen susceptibility at heterochromatic cancer driver loci
The retinoblastoma protein regulates mutagenic potential via control of UV-induced DNA lesion acquisition, thus revealing novel mechanisms that contribute to its tumor suppressor capabilities.
- Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis
Necrotic debris and STING affect tumor cell growth by altering cholesterol homeostasis in opposing manner, revealing that modulation of cellular cholesterol load may help control tumor growth.
- Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law
This study globally investigates the allelic splicing pattern in multiple tissues of an F1 hybrid mouse and reveals the underlying driving forces shaping such tissue-dependent splicing divergence.
- Electron cryo-tomography structure of axonemal doublet microtubule from Tetrahymena thermophila
By using electron cryo-tomography and subtomogram average, this study reveals the assembly of T. thermophila axonemal MT doublet in wild type and mutant, showing its structure conservation and diversity compared to other organisms.
- ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway
Cellular RNA transcripts in endothelial cells, especially the SINE RNAs, need extensive editing by the A-to-I RNA editing enzyme ADAR1, which is essential for neonatal survival by regulating the MDA-5–mediated RNA-sensing signaling pathway.
- Poly(ADP-ribosyl)ating pathway regulates development from stem cell niche to longevity control
The phosphorylation of poly(ADP-risobyl) glycohydrolase is involved in stem-cells differentiation, embryonic/larval development, regulation of longevity and fertility by calorie restriction.
- Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity
Using cryo-ET, cell biology, and proteomics, this study shows that aggregating proteins impair the autophagy-lysosomal pathway in neurons by sequestering a subunit of the AP-3 adaptor complex.
- Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrity
This study describes the the role of a nuclear pore complex protein in mammalian in skeletal muscle maintenance, repair, and function.