More articles from Research Articles
BACH1 as a key driver in rheumatoid arthritis fibroblast-like synoviocytes identified through gene network analysisThe study identifies BACH1 as a key driver of fibroblast-like synoviocyte pathogenicity in rheumatoid arthritis, highlighting its role in regulating fatty acid metabolism and ferroptosis.
Structural and biochemical analysis of ligand binding in yeast Niemann–Pick type C1–related proteinResults of X-ray crystallography and binding assays with different lipids expand our knowledge of the substrate scope of the Niemann–Pick type C1–related proteins NCR1 and NPC2 in yeast.
SNX5 promotes antigen presentation in B cells by dual regulation of actin and lysosomal dynamicsB cells form SNX5-rich protrusions at the plasma membrane, which dissipate upon interaction with soluble antigens. SNX5 accumulates at the immune synapse regulating actin-dependent spreading responses. SNX5 regulates endolysosomal trafficking required to promote antigen extraction and presentation.
CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregationGenerating various CENP-C mutant cell lines, Kong et al demonstrated that there is a positive regulatory loop between Aurora B recruitment and the CENP-C-Mis12C interaction at kinetochores in mammalian cells.
Microglia are essential for tissue contraction in wound closure after brain injury in zebrafish larvaeAlthough in humans, the brain fails to heal after an injury, young zebrafish are able to restore tissue structural integrity in less than 24 h, thanks to the mechanical action of microglia.
Mitochondrial apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathwaysMulti-omics studies combined with functional assays reveal that mitochondrial apolipoprotein MIC26 located in the inner membrane regulates central cellular fuel pathways in a MICOS-independent manner.
The hGIDGID4 E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migrationThis study shows that the hGIDGID4 E3 ligase controls cell migration by ubiquitinating ARHGAP11A for degradation, thereby regulating RhoA activity.
NAD+ depletion is central to placental dysfunction in an inflammatory subclass of preeclampsiaInflammatory preeclampsia exhibits a decline in placental NAD+ levels along with mitochondrial impairment, which could be ameliorated by supplementing with NAD+ boosters during pregnancy.
Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafishA zebrafish knockout model of the N-terminal acetyltransferase Naa80 demonstrates that this enzyme is required for actin N-terminal acetylation and normal inner ear development.
Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanismsThis work reveals the defects caused by the absence of laminin-α2, including impaired myoblast proliferation and differentiation, DNA damage, oxidative stress, and mitochondrial dysfunction, highlighting its important role in muscle development and cellular homeostasis.