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STAT3 inhibition recovers regeneration of aged muscles by restoring autophagy in muscle stem cellsThis study shows that STAT3 regulates MuSC function by both transcription-dependent and transcription-independent control of autophagy. STAT3 inhibition reverses age-dependent impairment of muscle regeneration, by restoring autophagy in aged MuSCs.
Mitochondrial lipidomes are tissue specific – low cholesterol contents relate to UCP1 activityThe mitochondria’s lipid composition is key for brown adipose tissue function. High cholesterol contents block UCP1 activity, whereas increasing phosphatidyl-choline and -ethanolamine levels boost it.
Nono induces Gadd45b to mediate DNA repairRNA-binding proteins are often deregulated in tumours, and this study reveals that the multifunctional splicing factor Nono promotes the induction of the DNA repair factor Gadd45b to prevent genome instability in murine non–small-cell lung cancer cells.
Off-targets of BRAF inhibitors disrupt endothelial signaling and vascular barrier functionClinically used therapies against BRAF-mutant melanoma have differential off-target effects on the phosphoproteome of endothelial cells, cell-cell junction architecture and vascular permeability.
IpaA reveals distinct modes of vinculin activation during Shigella invasion and cell-matrix adhesionMutational analysis supports a role for IpaA-mediated vinculin head domain oligomerization in the maturation of focal adhesions during Shigella invasion of epithelial cells.
Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expressionThe RNA-binding proteins Regnase-1 and -3 are central co-regulators of mast cell inflammatory responses. Specifically, Regnase-1 affects mast cell survival and proliferation; instead, both Regnases modulate the expression of inflammatory molecules, with the cytokine TNF being a primary target.
Transient PU.1 low fetal progenitors generate lymphoid progeny that contribute to adult immunityTransient PU.1low fetal progenitors generate activated and memory T and B cells that colonize and are maintained in secondary lymphoid tissues and make an early and long-term contribution to the adult immune system.
The importance of DNA sequence for nucleosome positioning in transcriptional regulationMachine learning on DNA sequences shows that nucleosomes are positioned by DNA sequence patterns to support the stages of transcription by directing competition between nucleosomes and transcription factors, as well as regulating RNA polymerase II dynamics.
PrgE: an OB-fold protein from plasmid pCF10 with striking differences to prototypical bacterial SSBsEnterococcal PrgE, from the conjugative plasmid pCF10, is a non-typical SSB that not only binds ssDNA in a filamentous manner but also binds dsDNA equally well as ssDNA.
Differential growth regulates asymmetric size partitioning in Caulobacter crescentusWe develop a quantitative model for asymmetric size partitioning in bacteria based on differential growth of daughter cell compartments.