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More articles from Research Articles

  • Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy
    Open Access
    Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy

    Tiffany C Blair, Shelly Bambina, Gwen F Kramer, Alexa K Dowdell, Alejandro F Alice, Jason R Baird, Amanda W Lund, Brian D Piening, Marka R Crittenden, Michael J Gough

    Tiffany C Blair ... Michael J Gough

    Published 29 April 2022

    Radiation therapy impacts all cells within the treatment field. Using novel technology, we track dendritic cells from the tumor to lymph nodes and demonstrate their importance in immune control of tumors.

  • Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift
    Open Access
    Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift

    Ali Hageb, Torsten Thalheim, Kalpana J Nattamai, Bettina Möhrle, Mehmet Saçma, Vadim Sakk, Lars Thielecke, Kerstin Cornils, Carolin Grandy, Fabian Port, Kay-E Gottschalk, Jan-Philipp Mallm, Ingmar Glauche, Jörg Galle, Medhanie A Mulaw, Hartmut Geiger

    Ali Hageb ... Hartmut Geiger

    Published 29 April 2022

    Analysis of clonal dynamics of intestinal stem cells supports an accelerated clonal drift upon aging, likely because of reduced adhesion of aged ISCs because of reduced canonical Wnt signaling.

  • Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cells
    Open Access
    Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cells

    Koji Kikuchi, Yasuhisa Sakamoto, Akiyoshi Uezu, Hideyuki Yamamoto, Kei-ichiro Ishiguro, Kenji Shimamura, Taro Saito, Shin-ichi Hisanaga, Hiroyuki Nakanishi

    Koji Kikuchi ... Hiroyuki Nakanishi

    Published 25 April 2022

    The microtubule-associated proteins Map7D2 and Map7D1, which belong to the MAP7 family, stabilize microtubules through distinct mechanisms for the control of cell motility and neurite outgrowth.

  • Nutrient sensitive protein <em>O</em>-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis
    Open Access
    Nutrient sensitive protein O-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis

    Shama Parween, Thilina T Alawathugoda, Ashok D Prabakaran, S Thameem Dheen, Randall H Morse, Bright Starling Emerald, Suraiya A Ansari

    Shama Parween ... Suraiya A Ansari

    Published 25 April 2022

    Maternal hyperglycemia and elevated O-GlcNAc levels perturb promoter bivalency and lead to transcriptional up-regulation of neurogenic transcription factors during embryonic neurogenesis.

  • Subgenomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaption
    Open Access
    Subgenomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaption

    Lin Lyu, Ru Feng, Mingnan Zhang, Xiaoqing Xie, Yinjing Liao, Yanjiao Zhou, Xiaokui Guo, Bing Su, Yair Dorsett, Lei Chen

    Lin Lyu ... Lei Chen

    Published 25 April 2022

    CORONATATOR, developed to analyze the subgenomic RNA of coronavirus, was applied on large number of sequencing data sets from coronaviruses, and shed light on viral gene regulation.

  • Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5
    Open Access
    Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5

    Lisa Merklinger, Johannes Bauer, Per A Pedersen, Rune Busk Damgaard, J Preben Morth

    Lisa Merklinger ... J Preben Morth

    Published 22 April 2022

    This study shows that lipids can act as regulators for the ubiquitination process and can control the stability and activity of a membrane-embedded E3 ubiquitin ligase.

  • The miR-26 family regulates early B cell development and transformation
    Open Access
    The miR-26 family regulates early B cell development and transformation

    Katharina Hutter, Silke E Lindner, Constanze Kurschat, Thomas Rülicke, Andreas Villunger, Sebastian Herzog

    Katharina Hutter ... Sebastian Herzog

    Published 22 April 2022

    We show that the activity of the miR-26 family determines early B cell behavior: high miR-26 levels promote cell expansion and block the pre-B to immature B cell transition, whereas a miR-26 reduction limits expansion and enhances pre-B cell differentiation.

  • The value of genotype-specific reference for transcriptome analyses in barley
    Open Access
    The value of genotype-specific reference for transcriptome analyses in barley

    Wenbin Guo, Max Coulter, Robbie Waugh, Runxuan Zhang

    Wenbin Guo ... Runxuan Zhang

    Published 22 April 2022

    We demonstrate in this study that using a common reference genome may lead to loss of genotype-specific information in the assembled Reference Transcript Dataset (RTD) and the generation of erroneous, incomplete, or misleading transcriptomics analysis results in barley.

  • Adipose tissue–specific ablation of Ces1d causes metabolic dysregulation in mice
    Open Access
    Adipose tissue–specific ablation of Ces1d causes metabolic dysregulation in mice

    Gang Li, Xin Li, Li Yang, Shuyue Wang, Yulin Dai, Baharan Fekry, Lucas Veillon, Lin Tan, Rebecca Berdeaux, Kristin Eckel-Mahan, Philip L Lorenzi, Zhongming Zhao, Richard Lehner, Kai Sun

    Gang Li ... Kai Sun

    Published 22 April 2022

    Ces1d is a crucial enzyme in adipose tissue. Here, we found a high level of Ces1d translocates onto lipid droplets where it digests the lipids to produce unique fatty acids which are key for glucose and lipid metabolism.

  • Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation
    Open Access
    Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation

    Minas Nalbandian, Mingming Zhao, Hiroki Kato, Tatsuya Jonouchi, May Nakajima-Koyama, Takuya Yamamoto, Hidetoshi Sakurai

    Minas Nalbandian ... Hidetoshi Sakurai

    Published 22 April 2022

    This study identified and characterized four different populations of muscle progenitor cells derived from human induced pluripotent stem cells.

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