More articles from Research Articles
Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapyRadiation therapy impacts all cells within the treatment field. Using novel technology, we track dendritic cells from the tumor to lymph nodes and demonstrate their importance in immune control of tumors.
Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal driftAnalysis of clonal dynamics of intestinal stem cells supports an accelerated clonal drift upon aging, likely because of reduced adhesion of aged ISCs because of reduced canonical Wnt signaling.
Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cellsThe microtubule-associated proteins Map7D2 and Map7D1, which belong to the MAP7 family, stabilize microtubules through distinct mechanisms for the control of cell motility and neurite outgrowth.
Nutrient sensitive protein O-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesisMaternal hyperglycemia and elevated O-GlcNAc levels perturb promoter bivalency and lead to transcriptional up-regulation of neurogenic transcription factors during embryonic neurogenesis.
Subgenomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaptionCORONATATOR, developed to analyze the subgenomic RNA of coronavirus, was applied on large number of sequencing data sets from coronaviruses, and shed light on viral gene regulation.
Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5This study shows that lipids can act as regulators for the ubiquitination process and can control the stability and activity of a membrane-embedded E3 ubiquitin ligase.
The miR-26 family regulates early B cell development and transformationWe show that the activity of the miR-26 family determines early B cell behavior: high miR-26 levels promote cell expansion and block the pre-B to immature B cell transition, whereas a miR-26 reduction limits expansion and enhances pre-B cell differentiation.
The value of genotype-specific reference for transcriptome analyses in barleyWe demonstrate in this study that using a common reference genome may lead to loss of genotype-specific information in the assembled Reference Transcript Dataset (RTD) and the generation of erroneous, incomplete, or misleading transcriptomics analysis results in barley.
Adipose tissue–specific ablation of Ces1d causes metabolic dysregulation in miceCes1d is a crucial enzyme in adipose tissue. Here, we found a high level of Ces1d translocates onto lipid droplets where it digests the lipids to produce unique fatty acids which are key for glucose and lipid metabolism.
Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferationThis study identified and characterized four different populations of muscle progenitor cells derived from human induced pluripotent stem cells.