More articles from Research Articles
- USP27X variants underlying X-linked intellectual disability disrupt protein function via distinct mechanisms
This study uncovers mechanisms by which X-linked intellectual disability disorder 105 (#300984; OMIM) variants alter USP27X biology and function.
- Early Atf4 activity drives airway club and goblet cell differentiation
PERK/Atf4 drives airway epithelial differentiation, impacting secretory cell numbers, revealing ATF4’s role in respiratory tract regeneration.
- Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors
Two anti-PD-1 antibodies bind to distinct glycoforms of PD-1 found on cells or in blood, highlighting the potential of target glycoprofiling in the development of differentiated therapeutics.
- Pridopidine subtly ameliorates motor skills in a mouse model for vanishing white matter
Assessment of the therapeutic efficacy of 4-PBA, TUDCA, and pridopidine in a vanishing white matter mouse model shows that only pridopidine subtly ameliorates motor skills.
- Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport
The membrane-bound serine protease Tmprss2 is required for ENaC-mediated transepithelial sodium and EpCAM-mediated paracellular transport in kidney cells.
- 2′,3′ cyclic nucleotide 3′ phosphodiesterase 1 functional isoform antagonizes HIV-1 particle assembly
CNP1, not CNP2, is the primary isoform inhibiting HIV-1, highlighting posttranslational regulation in CNP antiviral role.
- Sterile protection against P. vivax malaria by repeated blood stage infection in the Aotus monkey model
Repeated blood stage infections with the human malaria parasite, Plasmodium vivax, induce sterile strain-specific and partial strain-transcendent protection in the Aotus monkey model.
- The memory of airway epithelium damage in smokers and COPD patients
This study demonstrates that the COPD bronchial epithelium retains a memory of past injuries, allowing for prolonged in vitro replication of its abnormal phenotype, showcasing altered differentiation, barrier dysfunction, and epithelial-to-mesenchymal transition, thereby suggesting potential epigenetic modifications in its progenitors.
- Extreme trait GWAS (Et-GWAS): Unraveling rare variants in the 3,000 rice genome
Using extreme bulk pooling and allele frequency assessment, the graphical user interface (GUI)-enabled association technique successfully revealed relationships between genetic variations and grain yield under drought stress condition.
- VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis
Exposure of initial dermal lymphatics to VEGFA or a tumor results in zippering of VE-cadherin at junctions, concomitant with Src-dependent VE-cadherin fragmentation.