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An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinomaMETH use is associated with a higher incidence of hepatocellular carcinoma (HCC) in METH abusers and rehabilitees. METH exposure promotes HCC progression by ROS-mediated activation of the Ras/MEK/ERK signaling pathway. Clearance of ROS by NAC abolishes METH-induced HCC progression.
Human adenylyl cyclase 9 is auto-stimulated by its isoform-specific C-terminal domainThe isoform-specific carboxyl-terminal domain stimulates cAMP production by AC9 and also prevents its activation by cell-surface receptors. An interplay between the coiled-coil and the carboxyl-terminal domain of AC9 in regulating cAMP output is also shown.
Protein S-palmitoylation regulates different stages of meiosis in Schizosaccharomyces pombeThe vital role of S-palmitoylation in cell differentiation is demonstrated in the fission yeast by showing that the modification is required at multiple meiotic stages including mating and karyogamy.
Vasopressin V1a receptor and oxytocin receptor regulate murine sperm motility differentlyEpididymal vasopressin V1a receptor is involved in the regulation of sperm motility, and its antagonist may be a therapeutic agent for male-type reproductive dysfunction.
Lineage tracing reveals fate bias and transcriptional memory in human B cellsWe combined lineage tracing and single-cell transcriptomics to quantify the extent of cell-intrinsic fate bias in human B cells.
Structure of SALL4 zinc finger domain reveals link between AT-rich DNA binding and Okihiro syndromeSALL4 recognises AT-rich DNA motifs via a pair of evolutionarily conserved zinc fingers, and mutations of residues critical for DNA binding are responsible for a rare developmental disorder.
Secondary findings in a large Pakistani cohort tested with whole genome sequencingTesting a large Pakistani cohort with whole genome sequencing, we concluded that in countries such as Pakistan, the list of ACMG secondary findings could be expanded.
Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscleReplacement of amino acids unique to GDF11 and GDF8 into the native locus of the other ligand yields measurable, differential skeletal and muscle phenotypes, revealing distinct features between the ligands and a requirement for GDF11 in early-stage skeletal development.
Linking medicinal cannabis to autotaxin–lysophosphatidic acid signalingThe authors show that Δ9-trans-tetrahydrocannabinol, the main psychoactive compound in medicinal cannabis, could be considered as a therapeutic agent by inhibiting autotaxin–lysophosphatidic acid production.
SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axisSMN contributes to muscle maturation by binding to the promoter regions of MYOD1 and miRNAs and regulating the expression of these molecules during myogenesis.