More articles from Research Articles
Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal parvalbumin interneuronsParvalbumin interneurons in the dorsal striatum lose primary cilia in mice and humans harboring Parkinson’s disease–associated, activating mutations in LRRK2 kinase, resulting in loss of hedgehog signaling and decreased production of neuroprotective Neurturin to support dopamine neurons.
KAT6B is required for histone 3 lysine 9 acetylation and SOX gene expression in the developing brainHeterozygous mutations in the MYST family histone lysine acetyltransferase, KAT6B, cause intellectual disability disorders. This study identifies the histone and gene targets of KAT6B which include SOX2, a master regulator of neural stem and progenitor cells.
Nef mediates neuroimmune response, myelin impairment, and neuronal injury in EcoHIV-infected miceAntiretroviral therapy (ART) has improved HIV-associated neurocognitive disorder (HAND) outcomes, but nearly half of individuals remain affected. This study reveals how the HIV protein Nef drives neuroinflammation and neuronal damage, highlighting potential therapeutic targets for HAND-related neuropathology.
Noncanonical altPIDD1 protein: unveiling the true major translational output of the PIDD1 geneThis research uncovers PIDD1 as a dual-coding gene, revealing a previously unknown protein, altPIDD1, as the primary product with higher expression and cytoskeletal interactions.
Notch signaling mediates between two pattern-forming processes during head regeneration in HydraIn Hydra, Notch is required for head regeneration to harmonize two signaling and transcription factor modules for reforming two independent structures—a hypostome and a ring of tentacles; Craspedacusta polyps, in contrast, regenerate their tentacle-less heads independently of Notch.
Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in miceThis study shows how necroptotic effector MLKL can induce obesity and perturb lipid metabolism to drive MAFLD progression, independent of RIPK3 that regulates inflammatory events.
Antigen-specific modulation of chronic experimental autoimmune encephalomyelitis in humanized mice by TCR-like antibody targeting autoreactive T-cell epitopeTCR-like antibodies mediate the therapeutic effect of EAE/MS.
PTPN1/2 inhibition promotes muscle stem cell differentiation in Duchenne muscular dystrophyOur study identifies PTPN1/2 as potential therapeutic targets for Duchenne muscular dystrophy and suggests the use of PTPN1/2 inhibitors to enhance the myogenic function of DMD muscle stem cells.
Targeting TREM2 signaling shows limited impact on cerebrovascular calcificationMicroglia protect the brain from calcification and require the TREM2 receptor for this role. Here, we find that boosting TREM2 function using an antibody increases a TREM2-dependent response of microglia to vascular calcifications but is insufficient to resolve the pathology.
Decoupling actin assembly from microtubule disassembly by TBC1D3C-mediated direct GEF-H1 activationOur findings reveal a novel mechanism whereby actin filament assembly is decoupled from microtubule disassembly, providing insights into the intricate regulation of the cytoskeleton.