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More articles from Research Articles

  • Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencing
    Open Access
    Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencing

    Lucas Jarry, Julie Descombin, Melody Nicolau, Ange Dussutour, Nathalie Picault, Guillaume Moissiard

    Lucas Jarry ... Guillaume Moissiard

    Published 2 February 2023

    The plant mobile domain proteins MAIN and MAIL1 control the expression of the epigenetic factor Microrchidia 1, which has been involved in transposable element silencing in Arabidopsis.

  • A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery
    Open Access
    A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery

    Patrick Essletzbichler, Vitaly Sedlyarov, Fabian Frommelt, Didier Soulat, Leonhard X Heinz, Adrijana Stefanovic, Benedikt Neumayer, Giulio Superti-Furga

    Patrick Essletzbichler ... Giulio Superti-Furga

    Published 1 February 2023

    The validation and interpretation of a genome-wide CRISRPko FACS screen via protein–protein interaction data yield a broad view of the molecular network-regulating phagocytosis in human cells.

  • Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma
    Open Access
    Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma

    Véronique N Lafleur, Silvia Halim, Hani Choudhry, Peter J Ratcliffe, David R Mole

    Véronique N Lafleur ... David R Mole

    Published 1 February 2023

    This pan-genomic study of crosstalk between HIF and AHR transcription factors reveals both antagonistic and cooperative interactions and highlights their relevance to kidney cancer and its treatment.

  • The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth
    Open Access
    The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth

    Marina Badenes, Emma Burbridge, Ioanna Oikonomidi, Abdulbasit Amin, Érika de Carvalho, Lindsay Kosack, Camila Mariano, Pedro Domingos, Pedro Faísca, Colin Adrain

    Marina Badenes ... Colin Adrain

    Published 31 January 2023

    The FERM domain protein iTAP/Frmd8, which binds to and stabilizes the ADAM17/iRhom sheddase complex at the cell surface, is a regulator of inflammation, epithelial homeostasis, and tumor growth in vivo.

  • The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance
    Open Access
    The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance

    Mira Brazane, Dilyana G Dimitrova, Julien Pigeon, Chiara Paolantoni, Tao Ye, Virginie Marchand, Bruno Da Silva, Elise Schaefer, Margarita T Angelova, Zornitza Stark, Martin Delatycki, Tracy Dudding-Byth, Jozef Gecz, Pierre-Yves Plaçais, Laure Teysset, Thomas Préat, Amélie Piton, Bassem A Hassan, Jean-Yves Roignant, Yuri Motorin, Clément Carré

    Mira Brazane ... Clément Carré

    Published 31 January 2023

    This study adds insights into FTSJ1 tRNA 2′-O-methylation–associated pathologies in humans and Drosophila by identification of novel FTSJ1 targets and neuron morphology defects.

  • Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling
    Open Access
    Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling

    Simran Goel, Rosario Oliva, Sadasivam Jeganathan, Verian Bader, Laura J Krause, Simon Kriegler, Isabelle D Stender, Chadwick W Christine, Ken Nakamura, Jan-Erik Hoffmann, Roland Winter, Jörg Tatzelt, Konstanze F Winklhofer

    Simran Goel ... Konstanze F Winklhofer

    Published 31 January 2023

    The E3 ubiquitin ligase HOIP generates linear ubiquitin chains that promote liquid-liquid phase separation of NEMO in vitro, which correlates with the formation of NEMO condensates and IKK complex activation in cells.

  • PKCβII activation requires nuclear trafficking for phosphorylation and Mdm2-mediated ubiquitination
    Open Access
    PKCβII activation requires nuclear trafficking for phosphorylation and Mdm2-mediated ubiquitination

    Xiao Min, Shujie Wang, Xiaohan Zhang, Ningning Sun, Kyeong-Man Kim

    Xiao Min ... Kyeong-Man Kim

    Published 30 January 2023

    Nuclear trafficking that accompanies ubiquitination and phosphorylation at critical residues plays essential roles in the activation of PKCβII, a representative member of the conventional PKC isoforms.

  • Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility
    Open Access
    Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility

    Mathieu Cinato, Ismena Mardani, Azra Miljanovic, Christina Drevinge, Marion Laudette, Entela Bollano, Marcus Henricsson, Johan Tolö, Marcos Bauza Thorbrügge, Max Levin, Malin Lindbom, Muhammad Arif, Pal Pacher, Linda Andersson, Charlotta S Olofsson, Jan Borén, Malin C Levin

    Mathieu Cinato ... Malin C Levin

    Published 30 January 2023

    We show that elevated cardiac Plin5 correlates with up-regulation of cardiac contraction–related processes, unraveling a novel Plin5 interaction with SERCA2 associated with improved calcium handling.

  • A cluster of broadly neutralizing IgG against BK polyomavirus in a repertoire dominated by IgM
    Open Access
    A cluster of broadly neutralizing IgG against BK polyomavirus in a repertoire dominated by IgM

    Ngoc-Khanh Nguyen, Marie-Claire Devilder, Laetitia Gautreau-Rolland, Cynthia Fourgeux, Debajyoti Sinha, Jeremie Poschmann, Maryvonne Hourmant, Céline Bressollette-Bodin, Xavier Saulquin, Dorian McIlroy

    Ngoc-Khanh Nguyen ... Dorian McIlroy

    Published 30 January 2023

    FACS sorting of patient B cells with fluorescent BKPyV VLPs, followed by 10xGenomics scRNAseq, generated a large dataset of BKPyV-specific antibody sequences, among which we were able to identify and characterize broadly neutralizing antibodies.

  • FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against <em>Candida albicans</em>
    Open Access
    FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans

    Rakesh Kulkarni, Siti Khadijah Kasani, Ching-Yen Tsai, Shu-Yun Tung, Kun-Hai Yeh, Chen-Hsin Albert Yu, Wen Chang

    Rakesh Kulkarni ... Wen Chang

    Published 30 January 2023

    FAM21 is essential for CD11c+ dendritic cell function to activate host immune response against C.albicans infection.

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