More articles from Research Articles
Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencingThe plant mobile domain proteins MAIN and MAIL1 control the expression of the epigenetic factor Microrchidia 1, which has been involved in transposable element silencing in Arabidopsis.
A genome-wide CRISPR functional survey of the human phagocytosis molecular machineryThe validation and interpretation of a genome-wide CRISRPko FACS screen via protein–protein interaction data yield a broad view of the molecular network-regulating phagocytosis in human cells.
Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinomaThis pan-genomic study of crosstalk between HIF and AHR transcription factors reveals both antagonistic and cooperative interactions and highlights their relevance to kidney cancer and its treatment.
The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growthThe FERM domain protein iTAP/Frmd8, which binds to and stabilizes the ADAM17/iRhom sheddase complex at the cell surface, is a regulator of inflammation, epithelial homeostasis, and tumor growth in vivo.
The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performanceThis study adds insights into FTSJ1 tRNA 2′-O-methylation–associated pathologies in humans and Drosophila by identification of novel FTSJ1 targets and neuron morphology defects.
Linear ubiquitination induces NEMO phase separation to activate NF-κB signalingThe E3 ubiquitin ligase HOIP generates linear ubiquitin chains that promote liquid-liquid phase separation of NEMO in vitro, which correlates with the formation of NEMO condensates and IKK complex activation in cells.
PKCβII activation requires nuclear trafficking for phosphorylation and Mdm2-mediated ubiquitinationNuclear trafficking that accompanies ubiquitination and phosphorylation at critical residues plays essential roles in the activation of PKCβII, a representative member of the conventional PKC isoforms.
Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractilityWe show that elevated cardiac Plin5 correlates with up-regulation of cardiac contraction–related processes, unraveling a novel Plin5 interaction with SERCA2 associated with improved calcium handling.
A cluster of broadly neutralizing IgG against BK polyomavirus in a repertoire dominated by IgMFACS sorting of patient B cells with fluorescent BKPyV VLPs, followed by 10xGenomics scRNAseq, generated a large dataset of BKPyV-specific antibody sequences, among which we were able to identify and characterize broadly neutralizing antibodies.
FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicansFAM21 is essential for CD11c+ dendritic cell function to activate host immune response against C.albicans infection.