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More articles from Research Articles

  • Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradation
    Open Access
    Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradation

    Veronica Birdsall, Konner Kirwan, Mei Zhu, Yuuta Imoto, Scott M Wilson, Shigeki Watanabe, Clarissa L Waites

    Veronica Birdsall ... Clarissa L Waites

    Published 30 May 2022

    This study describes an activity-dependent mechanism for transporting ESCRT-0 protein Hrs to synaptic vesicle (SV) pools, facilitating SV protein degradation in response to increased neuronal firing.

  • Comprehensive evolutionary analysis and nomenclature of plant G3BPs
    Open Access
    Comprehensive evolutionary analysis and nomenclature of plant G3BPs

    Aala A Abulfaraj, Hajime Ohyanagi, Kosuke Goto, Katsuhiko Mineta, Takashi Gojobori, Heribert Hirt, Naganand Rayapuram

    Aala A Abulfaraj ... Naganand Rayapuram

    Published 26 May 2022

    A thorough phylogenetic analysis of eukaryotic G3BPs (Rasputins) with a focus on plant G3BP proteins, classification into two subfamilies and a proposed systematic nomenclature.

  • Evolutionary association of receptor-wide amino acids with G protein–coupling selectivity in aminergic GPCRs
    Open Access
    Evolutionary association of receptor-wide amino acids with G protein–coupling selectivity in aminergic GPCRs

    Berkay Selçuk, Ismail Erol, Serdar Durdağı, Ogün Adebali

    Berkay Selçuk ... Ogün Adebali

    Published 25 May 2022

    Evolutionary analyses of aminergic G protein–coupled receptors reveal receptor-wide potential determinants of G protein–coupling selectivity.

  • Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations
    Open Access
    Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations

    Zixin Qin, Teng Huang, Maoni Guo, San Ming Wang

    Zixin Qin ... San Ming Wang

    Published 20 May 2022

    Deleterious variants in the DNA damage repair system can cause genome instability and increase cancer risk. The highly ethnic-specific DDR deleterious variation from this study suggests its potential relationship with different disease susceptibility in ethnic human populations.

  • Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response
    Open Access
    Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response

    Shingo Kose, Kenichiro Imai, Ai Watanabe, Akira Nakai, Yutaka Suzuki, Naoko Imamoto

    Shingo Kose ... Naoko Imamoto

    Published 17 May 2022

    Hikeshi mediates proper nucleocytoplasmic distribution of HSP70, which is important for regulating of HSF1 activity and nuclear proteostasis, and adaptive response to heat shock.

  • DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF
    Open Access
    DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF

    Nuria Gutierrez-Prat, Hedwig L Zuberer, Luca Mangano, Zahra Karimaddini, Luise Wolf, Stefka Tyanova, Lisa C Wellinger, Daniel Marbach, Vera Griesser, Piergiorgio Pettazzoni, James R Bischoff, Daniel Rohle, Chiara Palladino, Igor Vivanco

    Nuria Gutierrez-Prat ... Igor Vivanco

    Published 17 May 2022

    Our study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.

  • Expression regulation of genes is linked to their CpG density distributions around transcription start sites
    Open Access
    Expression regulation of genes is linked to their CpG density distributions around transcription start sites

    Hao Tian, Yueying He, Yue Xue, Yi Qin Gao

    Hao Tian ... Yi Qin Gao

    Published 17 May 2022

    In this work, we performed a gene classification which revealed that different gene clusters harbor distinct gene regulatory mechanisms as well as epigenetic mark and expression variations in tumorigenesis.

  • The HDL particle composition determines its antitumor activity in pancreatic cancer
    Open Access
    The HDL particle composition determines its antitumor activity in pancreatic cancer

    Raimund Oberle, Kristina Kührer, Tamina Österreicher, Florian Weber, Stefanie Steinbauer, Florian Udonta, Mark Wroblewski, Isabel Ben-Batalla, Ingrid Hassl, Jakob Körbelin, Matthias Unseld, Matti Jauhiainen, Birgit Plochberger, Clemens Röhrl, Markus Hengstschläger, Sonja Loges, Herbert Stangl

    Raimund Oberle ... Herbert Stangl

    Published 16 May 2022

    The authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.

  • Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy
    Open Access
    Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy

    Manon Garcia, Sylvain Kumanski, Alberto Elías-Villalobos, Chantal Cazevieille, Caroline Soulet, María Moriel-Carretero

    Manon Garcia ... María Moriel-Carretero

    Published 13 May 2022

    We describe a fully new remodeling event of the nuclear envelope surrounding the nucleolus: it partitions into its regular contact with the vacuole and a dramatic internalization of globular cytoplasmic portions within the nucleus.

  • <em>C9ORF72</em>-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons
    Open Access
    C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons

    Paolo M Marchi, Lara Marrone, Laurent Brasseur, Audrey Coens, Christopher P Webster, Luc Bousset, Marco Destro, Emma F Smith, Christa G Walther, Victor Alfred, Raffaele Marroccella, Emily J Graves, Darren Robinson, Allan C Shaw, Lai Mei Wan, Andrew J Grierson, Stephen J Ebbens, Kurt J De Vos, Guillaume M Hautbergue, Laura Ferraiuolo, Ronald Melki, Mimoun Azzouz

    Paolo M Marchi ... Mimoun Azzouz

    Published 13 May 2022

    Extracellularly delivered poly-GAs are internalised into astrocytes via an endocytosis-dependent pathway and then spread to motor neurons, implying non-cell autonomous mechanisms in C9ORF72-ALS/FTD.

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