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Tannins amount determines whether tannase-containing bacteria are probiotic or pathogenic in IBDTA-induced microbial metabolite GA displays dual effects on IBD. GA exerts its function through two ways: influence bacteria penetration and directly affect epithelial cells. Interaction between diet and microbial enzyme is pivotal in affecting IBD.
A novel hypervariable variable number tandem repeat in the dopamine transporter gene (SLC6A3)This VNTR has a heterozygosity value of 0.93, forms G-tetrads, and is in low linkage disequilibrium with surrounding sequence, making it a new site for genetic analysis.
ICOS costimulation is indispensable for the differentiation of T follicular regulatory cellsICOS signaling promotes T follicular regulatory cell differentiation during germinal center reaction safeguarding against autoantibody production.
The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activityMagnesium (Mg2+) binding to the human mitochondrial RNA splicing 2 (MRS2) protein channel amino terminal domain disrupts homomeric interactions and inhibits mitochondrial Mg2+ uptake as a negative feedback mechanism.
SRSF7 and SRSF3 depend on RNA sequencing motifs and secondary structures to regulate MicroprocessorMicroprocessor cleaves pri-miRNAs to produce miRNAs. SRSF7 and SRSF3 interact with specific RNA elements in pri-miRNAs to modulate the cleavage of Microprocessor, thereby regulating miRNA biogenesis.
Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defectOverexpression of Rif1 induces relocation of chromatin to nuclear periphery and mitotic defect, suggesting a role of regulated chromatin–nuclear membrane association in the proper progression of M phase.
Expansion microscopy reveals subdomains in C. elegans germ granulesVisualising C. elegans germ granules using the super resolution technique expansion microscopy against the backdrop of proteome staining reveals granule ultrastructure.
The organizer of chromatin topology RIF1 ensures cellular resilience to DNA replication stressThe conserved protein RIF1 stabilizes replication factories and regulates cohesin recruitment in response to replication stress to limit DNA lesions.
Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stressThis study reports that NLRP3 is down-regulated in cancers and identifies a novel non-immune function for NLRP3 in maintaining genome integrity through the control of ATM activation in response to DSB.
Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathwayCholesterol metabolism may be involved in the early steps of tumor dissemination. Epigenetic regulation of cholesterol synthesis and uptake is of great importance in this process and may constitute a vulnerability of the cancer cell that could be exploited pharmacologically.