More articles from Research Articles
- The Rtf1/Prf1-dependent histone modification axis counteracts multi-drug resistance in fission yeast
Mutations in a conserved histone modification axis confer a unique drug-tolerant phenotype in fission yeast, and suggest a mode of gene regulation shared with the Rpb1 C-terminal domain.
- Immunogenicity and effectiveness of an mRNA therapeutic vaccine for HPV-related malignancies
mHTV-02 functions as a candidate effective therapeutic mRNA-LNP vaccine via intramuscular or intratumoral administration routes for treating malignancies caused by HPV16 or HPV18 infections.
- Aberrant DNA methylation distorts developmental trajectories in atypical teratoid/rhabdoid tumors
This study describes how aberrant DNA methylation–driven epigenetic regulation affects DNA binding of key transcriptions and maintains the malignant, low differentiation cell state in AT/RTs.
- SIRT4 as a novel interactor and candidate suppressor of C-RAF kinase in MAPK signaling
This study proposed a novel extra-mitochondrial role of the tumor suppressor SIRT4 in negatively regulating the MAPK pathway by interacting with C-RAF kinase.
- CRL4DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent premature centriole duplication
This study identifies the E3 ubiquitin ligase, CRL4DCAF1, as a new regulator of polo-like kinase 4, PLK4, protein levels in the G2 phase of the cell cycle to prevent premature duplication of centrioles.
- The Golgi checkpoint: Golgi unlinking during G2 is necessary for spindle formation and cytokinesis
This work shows that Golgi complex disassembly during G2 is required for spindle formation and cytokinesis, thus revealing novel regulatory mechanisms that control the fidelity of mitosis.
- Genetic ablation of Immt induces a lethal disruption of the MICOS complex
A new conditional mouse model deleting Immt/MIC60 reveals the necessity of this protein in vivo and provides an important resource for future research into the mitochondrial MICOS complex.
- Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity
Cavefish evolved protection from starvation-induced liver damage through a reduction in fatty acid uptake regulated by FATP2, a mechanism conserved through 400 million years of animal evolution.
- Interrogating endothelial barrier regulation by temporally resolved kinase network generation
This study introduces TREKING, a methodology for broadly interrogating kinases to elucidate time-resolved functional kinase signaling networks that drive endothelial barrier disruption and recovery.
- C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis
C5aR antagonist and MEK inhibition combination therapy changes the tumor microenvironment and induces ongoing tumor cell phagocytosis.