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Ribosome recycling is coordinated by processive events in two asymmetric ATP sites of ABCE1The stepwise ribosome disassembly in the translation cycle of eukaryotes and archaea is scheduled by discrete molecular events within the asymmetric ribosome recycling factor ABCE1.
Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cellsDepletion of FACT in murine embryonic stem cells show mild changes on the nucleosomal landscape but widespread changes in the transcriptome, faster proliferation, and neuronal differentiation rates.
ERα activity depends on interaction and target site corecruitment with phosphorylated CREB1CREB1 interacts with, stimulates, and is necessary for estrogen receptor α activation by estrogen or cAMP signaling, and this cooperation may underlie their anti-apoptotic activities in breast cancer cells.
Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhAAN12855 is a novel cofactor-independent inhibitor of Mycobacterium tuberculosis InhA. AN12855 has potent activity against M. tuberculosis, good oral bioavailability, and comparable efficacy to isoniazid in infection models.
The Arabidopsis homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunityArabidopsis homolog of human G3BP1 negatively regulates plant immunity and defense responses. Atg3bp1 mutant lines show constitutive stomata closure, expression of a number of key defense marker genes, and accumulate salicylic acid.
Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vesselsMegakaryocytes enter bone marrow sinusoids to generate platelets by extrusion of internal membrane into the plasma membrane at fusion sites rather than microtubule-driven proplatelet extension.
Serine catabolism is essential to maintain mitochondrial respiration in mammalian cellsMitochondrial respiratory complex assembly requires the one-carbon unit generated from serine catabolism.
Pervasive allele-specific regulation on RNA decay in hybrid miceUsing a F1 hybrid mouse system, this study globally investigates the effects of cis-regulatory divergence on RNA decay in mammals and reveals the evolutionary roles of RNA decay regulation.
Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicityProteomics and neuropathological validation show that aberrant poly-GR/PR proteins in C9orf72 ALS/FTD bind STAU2 and ribosomes and inhibit translation.
β-Tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cellsThis study used human gene-edited cell models and image analysis to reveal that the tubulin C-terminal tails specifically regulate the dynamics of individual microtubules and coordinate microtubule behavior across the cell.