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CARM1 methylates MED12 to regulate its RNA-binding abilityCARM1 methylates MED12 at arginine 1899 to generate a TDRD3 binding site, which in turn regulates the ability of mediator to interact with activating ncRNAs and modulate gene expression.
Identification of Plasmodium GAPDH epitopes for generation of antibodies that inhibit malaria infectionThis study reports on the identification of two Plasmodium GAPDH epitope peptides that are responsible for sporozoite–Kupffer cell interaction and act as antigens against malaria infection.
Transposon silencing in the Drosophila female germline is essential for genome stability in progeny embryosSuppression of transposons by the Piwi-interacting RNA biogenesis factor Vasa in the supporting nurse cells is essential to prevent their accumulation in the developing oocyte, ensuring proper Drosophila embryonic development.
Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethalityMouse embryos with an ablated ability of integrins to bind laminins are still able to form basement membranes, but die just after implantation because of deficient extraembryonic development.
MBNL1 alternative splicing isoforms play opposing roles in cancerMBNL1 proteins lacking exon 7 (−ex7) are antisurvival factors with tumor suppressive role that cancer cells tend to down-regulate in favor of MBNL +ex7 isoforms.
Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translationThis study uses polysomal RNA sequencing to show that the translational efficiency of specific mRNA changes in long-lived Caenorhabditis elegans with reduced ubiquinone synthesis.
Chromatin-mediated translational control is essential for neural cell fate specificationChd5 loss links the up-regulation of ribosomal genes to enhanced translation, causing the untimely production of a master transcription factor that unleashes stem cells and alters cell fate.
Dynamic reorganisation of intermediate filaments coordinates early B-cell activationThis study examines the role of vimentin, a type III intermediate filament, in B-cell function using a combination of in vitro and in vivo assays, including super-resolution microscopic techniques.
Atomic force microscopy reveals structural variability amongst nuclear pore complexesStructural heterogeneity is resolved in isolated nuclear envelopes, revealing the lamina network and nuclear pore complexes of different sizes, as well as different morphologies in their transport barrier and different binding of nuclear transport receptors in the barrier.
Beetle luciferases with naturally red- and blue-shifted emissionNew crystal structures of red- and green blue–shifted beetle luciferases reveal that the color emission mechanism is dependent on the active site microenvironment affected by the conformation of loop regions.