More articles from Research Articles
Absence of MHC-II expression by lymph node stromal cells results in autoimmunityMHCII-restricted antigen presentation by lymph node stromal cells is essential for regulatory T-cell proliferation and functions, and for the regulation of autoimmunity.
Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoiesisModulation of DNMT3A splice variants causes transcript-specific DNA methylation and gene expression changes and affects differentiation. Particularly, transcript 2 is relevant in acute myeloid leukemia.
A role for MED14 and UVH6 in heterochromatin transcription upon destabilization of silencingThe TFIIH component UVH6 and the mediator subunit MED14 are differentially required for the release of heterochromatin silencing, and MED14 regulates non-CG DNA methylation in Arabidopsis.
Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with IHO1. Its N-terminal region forms a Pleckstrin homology domain, while its C-terminal region is interacting with MEI4.
Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasomeThis study provides a detailed molecular mechanism for caspase-11 activation within the non-canonical inflammasome, giving new insight into host defence against cytosolic bacterial infection.
Extracellular vesicles from mature dendritic cells (DC) differentiate monocytes into immature DCMature dendritic cells (DC) secrete substantial amounts of vesicles that are primarily ingested by monocytes, leading to differentiation processes in these target cells towards monocyte-derived DC.
Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellumPeroxisome biogenesis deficiency leads to increased expression of BDNF and of a truncated form of the BDNF receptor in the cerebellum, attenuates BDNF-TrkB signaling, and results in malformation of the cerebellum.
The BMP2/4 ortholog Dpp can function as an inter-organ signal that regulates developmental timingIncreased local trapping of morphogens within tissues as they grow would reduce circulating levels and can therefore provide a systemic readout of the status of their growth and maturation.
Plk1 regulates spindle orientation by phosphorylating NuMA in human cellsThis work reveals that Plk1 phosphorylates an evolutionarily conserved protein NuMA in human cells and this phosphorylation negatively regulates NuMA and thus dynein cortical localization in metaphase that is crucial for proper spindle orientation.
Substrate fluxes in brown adipocytes upon adrenergic stimulation and uncoupling protein 1 ablationQuantification of substrate fluxes in brown adipocytes clarifies contributors to extracellular acidification, identifies a futile cycle of lipolysis and re-esterification, and suggests a role for glycogen during activation.